{"id":6874,"date":"2021-07-30T00:08:58","date_gmt":"2021-07-29T15:08:58","guid":{"rendered":"https:\/\/bamboolab.yamasatoagr.com\/?p=6874"},"modified":"2022-11-17T10:28:29","modified_gmt":"2022-11-17T01:28:29","slug":"%e3%82%ad%e3%83%a9%e3%83%aa%e3%83%86%e3%82%a3","status":"publish","type":"post","link":"https:\/\/bamboolab.yamasatoagr.com\/?p=6874","title":{"rendered":"TCA\u56de\u8def\u3078\u306e\u7570\u8ad6\u30005,5"},"content":{"rendered":"\n<p>\u3000\u307e\u305a\u56f310\u3092\u3088\u304f\u898b\u3066\u6b32\u3057\u3044\u3002\u30d4\u30eb\u30d3\u30f3\u9178\u304b\u3089\u30aa\u30ae\u30b6\u30ed\u9162\u9178\u306e4\u4f4d\u306b\u53d6\u308a\u8fbc\u307e\u308c\u305fC13\u304b\u3089\u306a\u308b\u4e8c\u9178\u5316\u70ad\u7d20\u306f\u3001TCA\u56de\u8def\u3092\u56de\u308b\u306b\u3064\u308c\u03b1-\u30b1\u30c8\u30b0\u30eb\u30bf\u30eb\u9178\u306e1\u4f4d\u306e\u30ab\u30eb\u30dc\u30ad\u30b7\u30eb\u57fa\u3068\u306a\u308a\u3001\u30b3\u30cf\u30af\u9178\u3078\u3068\u8131\u70ad\u9178\u3055\u308c\u308b\u969b\u306bCO2\u3068\u3057\u3066\u518d\u653e\u51fa\u3055\u308c\u308b\u3053\u3068\u306b\u306a\u308b\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"806\" height=\"921\" src=\"https:\/\/bamboolab.yamasatoagr.com\/wp\/wp-content\/uploads\/2021\/07\/\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8-2021-07-29-23.02.43.png\" alt=\"\" class=\"wp-image-6907\" srcset=\"https:\/\/bamboolab.yamasatoagr.com\/wp\/wp-content\/uploads\/2021\/07\/\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8-2021-07-29-23.02.43.png 806w, https:\/\/bamboolab.yamasatoagr.com\/wp\/wp-content\/uploads\/2021\/07\/\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8-2021-07-29-23.02.43-263x300.png 263w, https:\/\/bamboolab.yamasatoagr.com\/wp\/wp-content\/uploads\/2021\/07\/\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8-2021-07-29-23.02.43-768x878.png 768w\" sizes=\"auto, (max-width: 806px) 100vw, 806px\" \/><figcaption>\u56f310\u3000\u30d4\u30eb\u30d3\u30f3\u9178\u306b\u53d6\u308a\u8fbc\u307e\u308c\u305f\u4e8c\u9178\u5316\u70ad\u7d20\u306f2-Oxoglutarate\uff08\u03b1-\u30b1\u30c8\u30b0\u30eb\u30bf\u30eb\u9178\uff09\u304b\u3089\u30b3\u30cf\u30af\u9178\u3078\u306e\u6bb5\u968e\u3067\u7cfb\u5916\u306b\u653e\u51fa\u3055\u308c\u308b<\/figcaption><\/figure>\n\n\n\n<p>\u3000\u3068\u3053\u308d\u304c\u3001\u56f3\u306e\u5185\u5074\u306b\u793a\u3057\u305f\u3088\u3046\u306b\u8fb2\u696d\u751f\u7269\u8cc7\u6e90\u7814\u7a76\u6240\u306e\u30b5\u30a4\u30c8\u306b\u63b2\u8f09\u3055\u308c\u3066\u3044\u308b\u56f3\u306b\u3088\u308c\u3070\u3001\u30d4\u30eb\u30d3\u30f3\u9178\u306b\u53d6\u308a\u8fbc\u307e\u308c\u305fC13\u306f\u03b1-\u30b1\u30c8\u30b0\u30eb\u30bf\u30eb\u9178\u306e1\u4f4d\u30685\u4f4d\u306b\u5206\u5e03\u3057\u3001TCA\u56de\u8def\u3092\u6d41\u308c\u308b\u3088\u3046\u306b\u63cf\u3044\u3066\u3042\u308b\u3002\u30e9\u30d9\u30eb\u3055\u308c\u305f5\u4f4d\u306e\u30ab\u30eb\u30dc\u30ad\u30b7\u30eb\u57fa\u306f\u30b3\u30cf\u30af\u9178\u306e\u6bb5\u968e\u3067\u4f4d\u7f6e\u60c5\u5831\u3092\u5931\u3044\u3001\u30ea\u30f3\u30b4\u9178\u304b\u3089\u30aa\u30ae\u30b6\u30ed\u9162\u9178\u306e\u4e8c\u3064\u306e\u30ab\u30eb\u30dc\u30ad\u30b7\u30eb\u57fa\u306b\u518d\u914d\u5206\u3055\u308c\u305f\u3042\u3068\u3001\u30a2\u30b9\u30d1\u30e9\u30ae\u30f3\u9178\u3078\u3001\u3042\u308b\u3044\u306f\u30db\u30b9\u30db\u30a8\u30ce\u30fc\u30eb\u30d4\u30eb\u30d3\u30f3\u9178\u3092\u901a\u3063\u3066\u30bb\u30ea\u30f3\u3084\u30b0\u30ea\u30b7\u30f3\u3078\u3001\u30d4\u30eb\u30d3\u30f3\u9178\u3092\u7d4c\u7531\u3057\u3066\u30a2\u30e9\u30cb\u30f3\u3078\u3068\u5909\u63db\u3055\u308c\u308b\u3053\u3068\u306b\u306a\u3063\u3066\u3044\u308b\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"655\" src=\"https:\/\/bamboolab.yamasatoagr.com\/wp\/wp-content\/uploads\/2021\/07\/\u30e2\u30c7\u30eb\u56f3-1-1024x655.png\" alt=\"\" class=\"wp-image-6903\" srcset=\"https:\/\/bamboolab.yamasatoagr.com\/wp\/wp-content\/uploads\/2021\/07\/\u30e2\u30c7\u30eb\u56f3-1-1024x655.png 1024w, https:\/\/bamboolab.yamasatoagr.com\/wp\/wp-content\/uploads\/2021\/07\/\u30e2\u30c7\u30eb\u56f3-1-300x192.png 300w, https:\/\/bamboolab.yamasatoagr.com\/wp\/wp-content\/uploads\/2021\/07\/\u30e2\u30c7\u30eb\u56f3-1-768x491.png 768w, https:\/\/bamboolab.yamasatoagr.com\/wp\/wp-content\/uploads\/2021\/07\/\u30e2\u30c7\u30eb\u56f3-1.png 1151w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><figcaption>\u56f3-9\u3000\u5927\u6c17\u4e2d\u306e\u4e8c\u9178\u5316\u70ad\u7d20\u3092\u30ab\u30a4\u30b3\u304c\u7e6d\u7cf8\u3092\u69cb\u6210\u3059\u308b\u30a2\u30df\u30ce\u9178\u306e\u4e2d\u3078\u53d6\u308a\u8fbc\u3080\u4ee3\u8b1d\u56de\u8def\u306e\u30e2\u30c7\u30eb\u56f3<\/figcaption><\/figure>\n\n\n\n<p>\u3000\u3069\u3053\u304b\u3001\u4f55\u304b\u304c\u304a\u304b\u3057\u3044\u306e\u3067\u3042\u308b\u3002\u554f\u984c\u306f\u30a2\u30bb\u30c1\u30ebCoA\u306e\u30aa\u30ae\u30b6\u30ed\u9162\u9178\u3078\u306e\u4ed8\u52a0\u53cd\u5fdc\u3092\u89e6\u5a92\u3059\u308b\u9175\u7d20\u304c\u9762\u9078\u629e\u5236\u3092\u6301\u3064\u304b\u3069\u3046\u304b\u3001\u4eca\u3072\u3068\u3064\u306e\u554f\u984c\u306f\u30af\u30a8\u30f3\u9178\u304b\u3089\u30b7\u30b9\u30a2\u30b3\u30cb\u30c3\u30c8\u9178\u3078\u306e\u8131\u6c34\u53cd\u5fdc\u3092\u89e6\u5a92\u3059\u308b\u9175\u7d20\u304c\u30d7\u30ed\u30ad\u30e9\u30eb\u306a\u4f4d\u7f6e\u306b\u3042\u308b\u4e8c\u3064\u306e\u30e1\u30c1\u30ec\u30f3\u57fa\u3092\u533a\u5225\u3067\u304d\u308b\u304b\u3069\u3046\u304b\u306e\u554f\u984c\u3067\u3042\u308b\u3002\u524d\u56de\u66f8\u3044\u305f\u3088\u3046\u306b\u3001\u6700\u521d\u306e\u30a2\u30bb\u30c1\u30ebCoA\u306e\u30aa\u30ae\u30b6\u30ed\u9162\u9178\u306e2\u4f4d\u306e\u30ab\u30eb\u30dc\u30cb\u30eb\u57fa\u3078\u306e\u4ed8\u52a0\u53cd\u5fdc\u306f<em>si<\/em>\u9762\u5074\u304b\u3089\u9078\u629e\u7684\u306b\u8d77\u3053\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u308b\u300a<em>Biochemistry<\/em>, <strong>29<\/strong>, 2213-2219\uff081990\uff09\u300b\u3002<\/p>\n\n\n\n<p>\u3000\u3053\u306e\u4e8c\u3064\u306e\u53cd\u5fdc\u306f\u9175\u7d20\u53cd\u5fdc\u306b\u304a\u3051\u308b\u7acb\u4f53\u5316\u5b66\u7684\u5236\u5fa1\u3068\u3044\u3046\u8996\u5ea7\u304b\u3089\u898b\u308b\u3068\u3068\u3066\u3082\u9762\u767d\u3044\u3057\u3001\u3046\u307e\u304f\u4f1d\u3048\u308b\u3053\u3068\u304c\u51fa\u6765\u308c\u3070\u6559\u80b2\u7684\u306b\u3082\u6709\u52b9\u306a\u984c\u6750\u306b\u306a\u308b\u3002\u56f311\u306e\u30a2\u30bb\u30c8\u30f3\u3001\u9178\u7d20\u539f\u5b50\u3092\u4e0b\u306b\u7f6e\u304d\u5c11\u3057\u3060\u3051\u56de\u8ee2\u3055\u305b\u305f\u5f62\u3067\u66f8\u3044\u3066\u3044\u308b\u3002\u3053\u306e\u30ab\u30eb\u30dc\u30cb\u30eb\u70ad\u7d20\u3092NADH\u306b\u7531\u6765\u3059\u308b\u6c34\u7d20\u5316\u7269\u30a4\u30aa\u30f3\u304c\u653b\u6483\u3059\u308b\u5834\u5408\u3001\u30a2\u30bb\u30c8\u30f3\u306e\u4e8c\u3064\u306e\u30e1\u30c1\u30eb\u57fa\u3068\u9178\u7d20\u539f\u5b50\u304c\u4f5c\u308b\u5e73\u9762\u306e\u53f3\u5074\u304b\u3089\u653b\u6483\u3059\u308b\u5834\u5408\u3068\uff08A\u7cfb\u8def\uff09\u3068\u5de6\u5074\u304b\u3089\u653b\u6483\u3059\u308b\u5834\u5408\uff08B\u7cfb\u8def\uff09\u304c\u5b58\u5728\u3059\u308b\u3002\u751f\u6210\u7269\u306f\u3044\u305a\u308c\u30822-\u30d7\u30ed\u30d1\u30ce\u2212\u30eb\u3067\u3042\u308a\u30012-\u30d7\u30ed\u30d1\u30ce\u30fc\u30eb\u306b\u306f\u4e0d\u6589\u4e2d\u5fc3\u306f\u5b58\u5728\u3057\u306a\u3044\u306e\u3067A\u7cfb\u8def\u3092\u901a\u308d\u3046\u3068B\u7cfb\u8def\u3092\u901a\u308d\u3046\u3068\u751f\u6210\u7269\u306f\u540c\u3058\u3082\u306e\u3067\u3042\u308b\u3002\u3053\u3046\u3044\u3046\u5834\u5408\u3001\u30a2\u30bb\u30c8\u30f3\u306b\u306f\u30d7\u30ed\u30ad\u30e9\u30ea\u30c6\u30a3\u2212\u304c\u5b58\u5728\u3057\u306a\u3044\u3068\u3044\u3046\u8868\u73fe\u3092\u3059\u308b\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"735\" src=\"https:\/\/bamboolab.yamasatoagr.com\/wp\/wp-content\/uploads\/2021\/07\/\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8-2021-07-29-23.17.34-1024x735.png\" alt=\"\" class=\"wp-image-6908\" srcset=\"https:\/\/bamboolab.yamasatoagr.com\/wp\/wp-content\/uploads\/2021\/07\/\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8-2021-07-29-23.17.34-1024x735.png 1024w, https:\/\/bamboolab.yamasatoagr.com\/wp\/wp-content\/uploads\/2021\/07\/\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8-2021-07-29-23.17.34-300x215.png 300w, https:\/\/bamboolab.yamasatoagr.com\/wp\/wp-content\/uploads\/2021\/07\/\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8-2021-07-29-23.17.34-768x551.png 768w, https:\/\/bamboolab.yamasatoagr.com\/wp\/wp-content\/uploads\/2021\/07\/\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8-2021-07-29-23.17.34.png 1365w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><figcaption>\u56f311\u3000\u30aa\u30ae\u30b6\u30ed\u9162\u9178\u306b\u5bfe\u3059\u308b\u30a2\u30bb\u30c1\u30ebCoA\u30a2\u30cb\u30aa\u30f3\u306e\u4ed8\u52a0\u53cd\u5fdc<\/figcaption><\/figure>\n\n\n\n<p>\u3000\u3068\u3053\u308d\u304c\u3001\u30a2\u30bb\u30c1\u30ebCoA\u304c\u30aa\u30ae\u30b6\u30ed\u9162\u9178\u3078\u4ed8\u52a0\u53cd\u5fdc\u3092\u884c\u3044\u30af\u30a8\u30f3\u9178\u3092\u4e0e\u3048\u308b\u53cd\u5fdc\u306b\u304a\u3044\u3066\u306f\u3001\u305d\u3093\u306a\u306b\u7c21\u5358\u306b\u306f\u884c\u304b\u306a\u3044\u306e\u3067\u3042\u308b\u3002\u53f3\u5074\u306e\u4e0a\u90e8\u306b\u66f8\u3044\u305f\u4e8c\u3064\u306e\u30aa\u30ae\u30b6\u30ed\u9162\u9178\u3001\u4e00\u5fdc\u93e1\u50cf\u4f53\u306b\u306a\u308b\u3088\u3046\u306b\u63cf\u3044\u3066\u3044\u308b\u304c\u3001\u3053\u306e\u5206\u5b50\u306b\u306f\u4e0d\u6589\u70ad\u7d20\u306f\u5b58\u5728\u3057\u306a\u3044\u306e\u3067(I)\u3068(II)\u306f\u540c\u3058\u3082\u306e\u3067\u3042\u308b\u3002\u3057\u304b\u3057\u306a\u304c\u3089\u3001\u3053\u306e\u4e8c\u3064\u306e\u5f0f\u306e\u30ab\u30eb\u30dc\u30cb\u30eb\u70ad\u7d20\u306b\u7d50\u5408\u3059\u308b\u539f\u5b50\u306b\u3064\u304dCahn-Ingold-Prelog\u306e\u9806\u4f4d\u5247\u306b\u5f93\u3063\u3066\u9806\u756a\u3092\u4ed8\u3051\u308b\u3068\u3001\u5de6\u5074\u306e\u56f3\u306b\u304a\u3044\u3066\u306f\u53f3\u56de\u308a\u306b\u306a\u308a\u5de6\u5074\u306e\u56f3\u306b\u304a\u3044\u3066\u306f\u53f3\u56de\u308a\u3068\u306a\u3063\u3066\u3057\u307e\u3046\u3002\u3053\u306e\u3088\u3046\u306b\u3042\u308b\u9762\u304b\u3089\u898b\u308b\u3068\u7d50\u5408\u3059\u308b\u539f\u5b50\u7fa4\u306e\u9806\u4f4d\u304c\u53f3\u56de\u308a\u306b\u306a\u308b\u5834\u5408\u3001\u305d\u306e\u9762\u3092<em>re<\/em>-\u9762\u3001\u53cd\u5bfe\u306b\u306a\u308b\u5834\u5408\u3092<em>si<\/em>-\u9762\u3068\u5b9a\u7fa9\u3059\u308b\u3002\u305d\u3053\u3067\u3060\u304c\u3001\u6b21\u306b\u63cf\u3044\u305f\u5f0f(II&#8217;)\u306f\u7acb\u4f53\u5316\u5b66\u306e\u8868\u8a18\u6cd5\u304b\u3089\u4f59\u308a\u8912\u3081\u3089\u308c\u305f\u3082\u306e\u3067\u306f\u306a\u3044\u304c\u3001\u30ab\u30eb\u30dc\u30cb\u30eb\u57fa\u306e\u70ad\u7d20\u539f\u5b50\u3068\u9178\u7d20\u539f\u5b50\u306e\u7d50\u5408\u8ef8\u3092\u4e2d\u5fc3\u306b\u3057\u306660\u5ea6\u7a0b\u5ea6\u5411\u3053\u3046\u5411\u304d\u306b\u56de\u8ee2\u3055\u305b\u305f\u56f3\u3067\u3042\u308b\u3068\u3057\u3066\u307f\u3066\u6b32\u3057\u3044\u3002\u3053\u306e\u5206\u5b50\u306e\u30ab\u30eb\u30dc\u30cb\u30eb\u57fa\u306b\u5bfe\u3057\u3066\u3001\u30a2\u30bb\u30c1\u30ebCoA\u306e\u30a2\u30cb\u30aa\u30f3\u304c\u4ed8\u52a0\u3059\u308b\u306e\u3060\u304c\u3001\u3053\u306e\u53cd\u5fdc\u306f<em>si<\/em>-\u9762\u5074\u304b\u3089\u8d77\u3053\u308b\u3002<\/p>\n\n\n\n<p>\u3000\u305d\u3046\u3059\u308b\u3068\u30af\u30a8\u30f3\u9178\uff08III)\u304c\u5f97\u3089\u308c\u308b\u306e\u3060\u304c\u3001\u56f0\u3063\u305f\u3053\u3068\u304c\u3042\u308b\u3002\u3044\u3084\u5225\u306b\u56f0\u308b\u308f\u3051\u3067\u306f\u306a\u3044\u306e\u3060\u304c\u3001\u30af\u30a8\u30f3\u9178\u306f\u4e0d\u6589\u70ad\u7d20\u3092\u6301\u305f\u306a\u3044\u306e\u3067\u3042\u308b\u3002\u5f93\u3063\u3066\u3001\u5143\u304b\u3089\u3042\u308b\u30ab\u30eb\u30dc\u30ad\u30b7\u30e1\u30c1\u30eb\u57fa\u3068\u3001\u30a2\u30bb\u30c1\u30ebCoA\u306b\u7531\u6765\u3059\u308b\u30ab\u30eb\u30dc\u30ad\u30b7\u30e1\u30c1\u30eb\u57fa\u306f\u901a\u5e38\u5316\u5b66\u7684\u306b\u306f\u533a\u5225\u3067\u304d\u306a\u3044\u3002\uff08\u3053\u3046\u3044\u3063\u3066\u826f\u3044\u304b\u3069\u3046\u304b\u4e00\u5bf8\u4e0d\u5b89\u3067\u3059\u3002\u30ab\u30eb\u30dc\u30ad\u30b7\u30e1\u30c1\u30ec\u30f3\u57fa\u3068\u3044\u3046\u8a00\u3044\u65b9\u304c\u3042\u308b\u306e\u3060\u308d\u3046\u304b\uff1f\uff09\u305d\u306e\u305f\u3081\u8fb2\u696d\u751f\u7269\u8cc7\u6e90\u7814\u7a76\u6240\u306e\u30b5\u30a4\u30c8\u306e\u56f3\u304c\u6210\u7acb\u3057\u305d\u3046\u306b\u601d\u3048\u308b\u306e\u3060\u304c\u3001\u81ea\u7136\u754c\u306f\u5c11\u3005\u610f\u5730\u60aa\u3067\u3042\u308b\u3002\u305d\u306e\u8a71\u306b\u884c\u304f\u524d\u306b\u3001\u30ab\u30fc\u30f3\u30fb\u30a4\u30f3\u30b4\u30eb\u30c9\u30fb\u30d7\u30ec\u30ed\u30fc\u30b0\u9806\u4f4d\u5247\u306b\u304a\u3044\u3066\u3001\u540c\u4f4d\u4f53\u306b\u3064\u3044\u3066\u306f\u8cea\u91cf\u6570\u306e\u5927\u304d\u3044\u3082\u306e\u304c\u5c0f\u3055\u3044\u3082\u306e\u3088\u308a\u9806\u4f4d\u304c\u9ad8\u3044\u3002\u73fe\u5b9f\u306e\u8a71\u3092\u3059\u308c\u3070\u3001\u30d4\u30eb\u30d3\u30f3\u9178\u3078\u53d6\u308a\u8fbc\u307e\u308c\u305f<sup>13<\/sup>CO<sub>2<\/sub>\u306f\u30aa\u30ae\u30b6\u30ed\u9162\u9178\u306e4\u4f4d\u306b\u5165\u308b\u306e\u3060\u304c\u3001\u305d\u306e\u307b\u3068\u3093\u3069\u306f<sup>12<\/sup>CO<sub>2<\/sub>\u306b\u7531\u6765\u3059\u308b\u70ad\u7d20\u539f\u5b50\u3067\u3042\u308b\u3002\u3064\u307e\u308a\u3053\u3053\u3067\u751f\u6210\u3059\u308b\u30af\u30a8\u30f3\u9178\u306f\uff08III\uff09\u306f\uff08IV\uff09\u306e\u6df7\u5408\u7269\u3067\u3042\u308b\u3068\u3044\u3046\u3053\u3068\u306b\u306a\u308b\u3002\u305d\u3057\u3066\u3001<sup>12<\/sup>CO<sub>2<\/sub>\u306b\u7531\u6765\u3059\u308b\u30ab\u30eb\u30dc\u30ad\u30b7\u30eb\u57fa\u3092\u6301\u3064\u30af\u30a8\u30f3\u9178(IV)\u306b\u304a\u3044\u3066\u306f\u4e0d\u6589\u70ad\u7d20\u306f\u5b58\u5728\u3057\u306a\u3044\u304c\u3001<sup>13<\/sup>CO<sub>2<\/sub>\u306b\u7531\u6765\u3059\u308b\u7531\u6765\u3059\u308b\u30ab\u30eb\u30dc\u30ad\u30b7\u30eb\u57fa\u3092\u6301\u3064\u30af\u30a8\u30f3\u9178(III)\u306e3\u4f4d\u306e\u70ad\u7d20\u306f\u4e0d\u6589\u70ad\u7d20\u3068\u306a\u308a\u3001\u305d\u306e\u7acb\u4f53\u914d\u7f6e\u306fR\u3067\u3042\u308b\u3068\u3044\u3046\u3053\u3068\u306b\u306a\u308b\u3002\u5c24\u3082\u3001\u540c\u4f4d\u4f53\u52b9\u679c\u3068\u3044\u3046\u73fe\u8c61\u304c\u3042\u308b\u3068\u306f\u3044\u3048\u3001\u3053\u306e<sup>13<\/sup>C\u3092\u6301\u3064\u30ab\u30eb\u30dc\u30ad\u30b7\u30eb\u57fa\u304c\u3001\u6b21\u306e\u8131\u6c34\u53cd\u5fdc\u306e\u8d77\u3053\u308b\u4f4d\u7f6e\u306b\u5f71\u97ff\u3059\u308b\u3053\u3068\u306f\u306a\u3044\u3068\u8003\u3048\u3066\u3088\u3044\u3060\u308d\u3046\u3002<\/p>\n\n\n\n<p>\u3000\u305d\u3053\u3067\u3060\u304c\u3001\u4e0d\u6589\u4e2d\u5fc3\u3092\u6301\u305f\u306a\u3044\u30af\u30a8\u30f3\u9178 (IV) \u306b\u304a\u3044\u3066\u3001\u4e8c\u3064\u306e\u30ab\u30eb\u30dc\u30ad\u30b7\u30e1\u30c1\u30eb\u57fa\u3092\uff08A\uff09\uff08B\uff09\u3068\u533a\u5225\u3057\u3066\u8003\u3048\u308b\u3053\u3068\u306b\u3059\u308b\u3002\u4f55\u3092\u3057\u3088\u3046\u3068\u3057\u3066\u3044\u308b\u304b\u3068\u3044\u3048\u3070\u30d7\u30ed\u30ad\u30e9\u30ea\u30c6\u30a3\u2212\u306e\u6982\u5ff5\u3092\u5c0e\u5165\u3057\u3088\u3046\u3068\u3057\u3066\u3044\u308b\u308f\u3051\u3067\u3042\u308b\u3002\u30d7\u30ed\u30ad\u30e9\u30ea\u30c6\u30a3\u2212\u306b\u3082\u8272\u3005\u306a\u7a2e\u985e\u304c\u3042\u308b\u306e\u3060\u304c\u3001\u3053\u3053\u3067\u8ff0\u3079\u308b\u306e\u306fsp<sup>3<\/sup>\u6df7\u6210\u8ecc\u9053\u3092\u6301\u3064\u70ad\u7d20\u4e0a\u306e 4\u500b\u306e\u7f6e\u63db\u57fa\u304c\u3001CX2YZ \u3068\u3044\u3046\u3088\u3046\u306b\u30012\u3064\u306e\u540c\u3058\u7f6e\u63db\u57fa X \u3068\u3001\u7570\u306a\u308b 2\u3064\u306e\u7f6e\u63db\u57fa Y\u3001Z \u304b\u3089\u306a\u308b\u5834\u5408\u3001\u305d\u306e\u70ad\u7d20\u306f\u5149\u5b66\u6d3b\u6027\u4e2d\u5fc3\u3067\u306f\u306a\u3044\u3002\u3057\u304b\u3057\u3001X \u304c\u65b0\u3057\u3044\u5225\u306e\u7f6e\u63db\u57fa W \u306b\u7f6e\u304d\u63db\u308f\u308c\u3070 CWXYZ \u306e\u5f62\u3068\u306a\u308a\u5149\u5b66\u6d3b\u6027\u4e2d\u5fc3\u3068\u306a\u308b\u3002\u305d\u3053\u3067CX2YZ \u4e0a\u306b\u3042\u308b 2\u500b\u306e X \u306b\u3064\u3044\u3066\u3001\u305d\u308c\u3089\u3092\u3069\u3046\u533a\u5225\u3059\u308b\u304b\u304c\u554f\u984c\u3068\u306a\u308b\u308f\u3051\u3067\u3042\u308b\u3002<\/p>\n\n\n\n<p>\u3000\u5927\u3057\u305f\u3053\u3068\u3067\u306f\u306a\u3044\u30022\u500b\u306e\u7f6e\u63db\u57fa X \u306e\u3046\u3061\u3069\u3061\u3089\u304b\u3092\u3082\u3046\u4e00\u500b\u306eX\u3088\u308a\u3082\u9ad8\u3044\u3082\u306e\u3068\u4eee\u5b9a\u3057\u305f\u3042\u3068 CIP\u5247\u3092\u9069\u7528\u3057\u3001\u512a\u5148\u9806\u4f4d\u3092\u6c7a\u3081\u308b\u3002\u4eee\u306e\u512a\u5148\u9806\u4f4d\u306b\u57fa\u3065\u304d\u3001RS\u8868\u8a18\u6cd5\u306b\u3057\u305f\u304c\u3063\u3066\u4e2d\u5fc3\u70ad\u7d20\u306e\u30ad\u30e9\u30ea\u30c6\u30a3\u304c R \u304b S \u304b\u3092\u6c7a\u3081\u308b\u306e\u3060\u304c\u3001\u4eee\u306e\u30ad\u30e9\u30ea\u30c6\u30a3\u30fc\u304cR\u4f53\u3060\u3063\u305f\u5834\u5408\u306f\u3001\u305d\u306e\u3068\u304d\u306b\u512a\u5148\u3055\u305b\u305f X \u3092<em> pro-R<\/em> \u306e\u7f6e\u63db\u57fa\u3068\u3001S\u4f53\u3060\u3063\u305f\u5834\u5408\u306f<em>pro-S<\/em> \u306e\u7f6e\u63db\u57fa\u3068\u79f0\u3059\u308b\u3002\u30af\u30a8\u30f3\u9178\u306b\u304a\u3044\u3066\u306f\u4e8c\u3064\u306e\u30ab\u30eb\u30dc\u30ad\u30b7\u30e1\u30c1\u30eb\u57fa\u304c\u3053\u306e\uff38\u306b\u5f53\u305f\u308b\u308f\u3051\u3067\u3042\u308b\u3002\u305d\u3046\u3057\u3066<em>pro-R<\/em> \u3068<em>pro-S<\/em>\u306b\u5bfe\u5fdc\u3059\u308b\u30ab\u30eb\u30dc\u30ad\u30b7\u30e1\u30c1\u30eb\u57fa\u3092\u6c7a\u3081\u308b\u3068\u56f311\u3082\u53f3\u4e0b\u306e\u3088\u3046\u306b\u306a\u308b\u3002\u3064\u307e\u308a\u3001\u30aa\u30ae\u30b6\u30ed\u9162\u9178\u306e4\u4f4d\u306b\u3042\u3063\u305f\u30ab\u30eb\u30dc\u30ad\u30b7\u30eb\u57fa\u306f<em>pro-R<\/em>\u306e\u30ab\u30eb\u30dc\u30ad\u30b7\u30e1\u30c1\u30eb\u57fa\u3068\u306a\u308a\u30a2\u30bb\u30c1\u30ebCoA\u306b\u7531\u6765\u3059\u308b\u30ab\u30eb\u30dc\u30ad\u30b7\u30eb\u57fa\u306f<em>pro-S<\/em>\u306e\u30ab\u30eb\u30dc\u30ad\u30b7\u30e1\u30c1\u30eb\u57fa\u306b\u306a\u3063\u3066\u3044\u308b\u306e\u3067\u3042\u308b\u3002\u3053\u308c\u3068\u53cd\u5bfe\u306e\u914d\u7f6e\u306e\u5316\u5408\u7269\u3092\u4f5c\u308b\u9175\u7d20\u3082\u3042\u308b\u306e\u306f\u3042\u308b\u306e\u3060\u304c\u3001\u5acc\u6c17\u6027\u306e\u5fae\u751f\u7269\u306b\u5b58\u5728\u3057\u3066\u3044\u308b\u3082\u306e\u3067\u3001\u30ab\u30a4\u30b3\u306b\u306f\u5b58\u5728\u3057\u306a\u3044\u3002<\/p>\n\n\n\n<p>\u3000<em>pro-S<\/em>\u3068\u304b<em>pro-R<\/em>\u3068\u304b\u9b31\u9676\u3057\u3044\u306a\u3001\u305d\u308c\u304c\u3069\u3046\u3057\u305f\u3068\u3044\u3046\u58f0\u304c\u805e\u3053\u3048\u3066\u304d\u305d\u3046\u306a\u306e\u3060\u304c\u3001\u3053\u3053\u306f\u91cd\u8981\u306a\u30b9\u30c6\u30c3\u30d7\u3068\u306a\u308b\u3002\u30a2\u30ad\u30e9\u30eb\u306a\u30af\u30a8\u30f3\u9178\u304b\u3089<em>cis<\/em>-\u30a2\u30b3\u30cb\u30c3\u30c8\u9178\u3078\u306e\u5909\u63db\u306f\u3001\u30c8\u30e9\u30f3\u30b9\u8131\u96e2\u53cd\u5fdc\u3067\u8131\u6c34\u304c\u8d77\u3053\u308a <em>pro-R<\/em>\u5074\u306e\u30ab\u30eb\u30dc\u30ad\u30b7\u30e1\u30c1\u30eb\u57fa\u5074\u306b\u4e8c\u91cd\u7d50\u5408\u304c\u5f62\u6210\u3055\u308c\u308b\u300a<em>Proc. Natl. Acad. Sci<\/em>., 93, 13699-13703 (1996)\u300b\u3002\u305d\u3053\u3067\u306f\u305f\u3068\u56f0\u3063\u3066\u3057\u307e\u3046\u306e\u3067\u3042\u308b\u3002<em>pro-R<\/em>\u5074\u306e\u5074\u9396\u306f\u30aa\u30ae\u30b6\u30ed\u9162\u9178\u306e4\u4f4d\u306e\u30ab\u30eb\u30dc\u30ad\u30b7\u30eb\u57fa\u3092\u542b\u3080\u3002\u305d\u306e\u30ab\u30eb\u30dc\u30ad\u30b7\u30eb\u57fa\u306e\u03b1\u03b2\u4f4d\u306b2\u91cd\u7d50\u5408\u304c\u5c0e\u5165\u3055\u308c\u308b\u306e\u3067\u3042\u308c\u3070\u3001\u9006\u5411\u304d\u306e\u6c34\u4ed8\u52a0\u306b\u7d9a\u304f\u57fa\u8cea\u30ec\u30d9\u30eb\u3067\u306e\u9178\u5316\u3001\u3055\u3089\u306b\u7d9a\u3044\u3066\u8d77\u3053\u308b2\u5ea6\u306e\u8131\u70ad\u9178\u53cd\u5fdc\u306b\u3088\u3063\u3066\u3001\u30aa\u30ae\u30b6\u30ed\u9162\u9178\u7531\u6765\u306e\u30ab\u30eb\u30dc\u30ad\u30b7\u30eb\u57fa\u306f\u4e8c\u9178\u5316\u70ad\u7d20\u3068\u3057\u3066\u653e\u51fa\u3055\u308c\u3066\u3057\u307e\u3046\u3067\u306f\u306a\u3044\u304b\u3002\u3064\u307e\u308a\u305b\u3063\u304b\u304f\u56fa\u5b9a\u3055\u308c\u305f<sup>13<\/sup>C\u306f\u3053\u306e\u6bb5\u968e\u3067\u5931\u308f\u308c\u3066\u3057\u307e\u3046\u3053\u3068\u3092\u610f\u5473\u3057\u3066\u3044\u308b\u3002<\/p>\n\n\n\n<p>\u3000\u5b9f\u306f\u8131\u6c34\u53cd\u5fdc\u304c\u30c8\u30e9\u30f3\u30b9\u8131\u96e2\u3067\u8d77\u3053\u308b\u3001\u7d9a\u304f\u53cd\u5bfe\u65b9\u5411\u3067\u306e\u6c34\u306e\u4ed8\u52a0\u53cd\u5fdc\u3068\u3053\u306e\u6642\u751f\u6210\u3059\u308b2\u4f4d\u306e\u6c34\u9178\u57fa\u30683\u4f4d\u306e\u70ad\u7d20\u306e\u7acb\u4f53\u5316\u5b66\u30012\u4f4d\u306e\u6c34\u9178\u57fa\u306e\u57fa\u8cea\u30ec\u30d9\u30eb\u3067\u306e\u9178\u5316\u306b\u4f34\u30462\u4f4d\u306e\u70ad\u7d20\u3068\u3053\u308c\u306b\u7d9a\u304f\u8131\u70ad\u9178\u306e\u4f34\u30463\u4f4d\u306e\u70ad\u7d20\u306e\u4e0d\u6589\u306e\u6d88\u5931\u3001\u3055\u3089\u306b\u3082\u3046\u4e00\u6bb5\u968e\u3001\u03b1\u30b1\u30c8\u9178\u306e\u8131\u70ad\u9178\u3068\u3001\u8208\u5473\u6df1\u3044\u53cd\u5fdc\u304c\u7d9a\u304f\u306e\u3060\u304c\u3001\u4f59\u308a\u3053\u306e\u624b\u306e\u8a71\u3092\u7d9a\u3051\u3066\u3082\u79c1\u3060\u3051\u3067\u306a\u304f\u8aad\u8005\u3082\u75b2\u308c\u308b\u3060\u3051\u3060\u3068\u601d\u3046\u306e\u3067\u3001\u8208\u5473\u306e\u3042\u308b\u65b9\u306f\u81ea\u5206\u3067\u6587\u732e\u3092\u3042\u3055\u3063\u3066\u6b32\u3057\u3044\u3002<\/p>\n\n\n\n<p>\u3000\u3064\u307e\u308a\u3053\u3053\u307e\u3067\u306e\u8b70\u8ad6\u3067\u4f55\u304c\u8a00\u3044\u305f\u3044\u304b\u3068\u3044\u3048\u3070\u3001\u3001\u30d4\u30eb\u30d3\u30f3\u9178\u3068<sup>13<\/sup>CO<sub>2<\/sub>\u3068\u306e\u53cd\u5fdc\u3067\u5f62\u6210\u3055\u308c\u305f\u30aa\u30ae\u30b6\u30ed\u9162\u9178\u304b\u3089TCA\u56de\u8def\u3092\u56de\u3057\u3066\u3001\u30a2\u30e9\u30cb\u30f3\u3001\u30bb\u30ea\u30f3\u3001\u30b0\u30ea\u30b7\u30f3\u3001\u30a2\u30b9\u30d1\u30e9\u30ae\u30f3\u9178\u3092\u59d3\u5408\u6210\u3059\u308b\u3068\u3057\u305f\u5834\u5408\u3001\u3053\u308c\u3089\u306e\u30a2\u30df\u30ce\u9178\u306e\u30ab\u30eb\u30dc\u30ad\u30b7\u30eb\u57fa\u306b\u3001<sup>13<\/sup>C\u304c\u542b\u307e\u308c\u308b\u3068\u3059\u308b\u8ad6\u8a3c\u306b\u306f\u7121\u7406\u304c\u3042\u308b\u306e\u3067\u306f\u306a\u3044\u304b\u3068\u3044\u3046\u306e\u304c\u79c1\u306e\u610f\u898b\u3067\u3042\u308b\u3002\u3057\u304b\u3057\u306a\u304c\u3089\u3001<sup>13<\/sup>CNMR\u306e\u30c7\u30fc\u30bf\u306f\u3001\u3053\u308c\u3089\u306e\u30a2\u30df\u30ce\u9178\u306e\u306b<sup>13<\/sup>C\u304c\u542b\u307e\u308c\u3066\u3044\u308b\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u308b\u3002\u3069\u3046\u8003\u3048\u308c\u3070\u3053\u306e\u77db\u76fe\u3092\u89e3\u6c7a\u3067\u304d\u308b\u306e\u3060\u308d\u3046\u304b\u3002<\/p>\n\n\n\n<p>\u3000\u4e45\u3057\u3076\u308a\u306b\u7acb\u4f53\u5316\u5b66\u7684\u306b\u53cd\u5fdc\u3092\u8003\u3048\u305f\u306e\u3060\u304c\u3001\u6614\u306f\u69cb\u9020\u5f0f\u3092\u898b\u308b\u3068\u982d\u306e\u4e2d\u3067\u7acb\u4f53\u69cb\u9020\u304c\u6d6e\u304b\u3073\u3001\u3053\u308c\u3092\u56de\u8ee2\u3055\u305b\u305f\u308a\u53cd\u8ee2\u3055\u305b\u305f\u308a\u81ea\u7531\u306b\u3067\u304d\u3066\u3044\u305f\u3002\u3068\u3053\u308d\u304c\u4eca\u56de\u3001ChemDraw\u3067\u63cf\u3053\u3046\u3068\u601d\u3063\u305f\u3089\u3001\u4e00\u5ea6\u7d19\u306b\u63cf\u3044\u3066\u304b\u3089\u3067\u306a\u3044\u3068\u9593\u9055\u3046\u306e\u3067\u3042\u308b\u3002\u3057\u3070\u3089\u304f\u3084\u3063\u3066\u3044\u306a\u304b\u3063\u305f\u304b\u3089\u306a\u306e\u304b\u8001\u3044\u305f\u306e\u304c\u539f\u56e0\u306a\u306e\u304b\u5206\u304b\u3089\u306a\u3044\u3002\u4e00\u65e5\u4e2d\u8349\u5208\u308a\u3068\u8349\u53d6\u308a\u3057\u304b\u3084\u3063\u3066\u3044\u306a\u3044\u306e\u3060\u304b\u3089\u3001\u4ed5\u65b9\u304c\u306a\u3044\u3060\u308d\u3046\u3002\u4f8b\u5e74\u306a\u3089\u5c11\u3057\u5965\u5c71\u306b\u79fb\u52d5\u3057\u3066\u3044\u308b\u306f\u305a\u306e\u30db\u30c8\u30c8\u30ae\u30b9\u304c\u964d\u308b\u3088\u3046\u306b\u9cf4\u3044\u3066\u3044\u308b\u3002\u65e5\u4e2d\u306e\u6e29\u5ea6\u306f35\u2103\u3092\u8d85\u3048\u76ee\u304c\u304f\u3089\u3080\u3088\u3046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