{"id":5623,"date":"2017-01-10T13:12:35","date_gmt":"2017-01-10T04:12:35","guid":{"rendered":"http:\/\/bamlab.ok-japan.com\/?p=5623"},"modified":"2019-11-02T13:12:55","modified_gmt":"2019-11-02T04:12:55","slug":"%e9%81%8e%e5%89%b0%e3%81%a8%e8%95%a9%e5%b0%bd%e3%80%8029","status":"publish","type":"post","link":"https:\/\/bamboolab.yamasatoagr.com\/?p=5623","title":{"rendered":"\u904e\u5270\u3068\u8569\u5c3d\u300029"},"content":{"rendered":"\n

\u3000\u3067\u306f\u307e\u305a\u3001\u30d7\u30ea\u30f3\u5869\u57fa\u306e\u751f\u5408\u6210\u304b\u3089\u59cb\u3081\u308b\u3053\u3068\u306b\u3059\u308b\u3002\u51fa\u767a\u306f\u524d\u56de\u307e\u3067\u8b70\u8ad6\u3057\u3066\u304d\u305f\u30b0\u30eb\u30bf\u30df\u30f3\u3068\u3044\u3046\u3053\u3068\u306b\u306a\u308b\u304c\u3001\u5b9f\u969b\u306e\u53cd\u5fdc\u3092\u898b\u308b\u3068\u305d\u308a\u3083\u306a\u3044\u3088\u3068\u601d\u3063\u3066\u3057\u307e\u3046\u3002\u307e\u305a\u306f\u6b21\u306e\u56f3\u3092\u898b\u3066\u307b\u3057\u3044\u3002\u3044\u3064\u3082\u901a\u308a\u306eKEGG\u3060\u3088\u308a\u3001KEGG\u306ePURINE METABOLISM\u306e\u30da\u30fc\u30b8\u3067\u3042\u308b\u3002<\/p>\n\n\n\n

\"\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8<\/a><\/figure><\/div>\n\n\n\n

\u3000\u539f\u56f3\u3092\u78ba\u8a8d\u3057\u3066\u307b\u3057\u3044\u304c\u3001\u3053\u306e\u30da\u30fc\u30b8\u3092\u898b\u3066\u3059\u3050\u306b\u5168\u4f53\u3092\u628a\u63e1\u3067\u304d\u308b\u4eba\u304c\u3069\u308c\u307b\u3069\u3044\u308b\u306e\u304b\u60f3\u50cf\u304c\u3064\u304b\u306a\u3044\u304c\u3001\u591a\u5206\u3001\u5927\u591a\u6570\u306e\u4eba\u304c\u5fc5\u8981\u306a\u90e8\u5206\u3060\u3051\u3092\u53c2\u7167\u3059\u308b\u3068\u3044\u3046\u4f7f\u3044\u65b9\u3092\u3057\u3066\u3044\u308b\u306b\u9055\u3044\u306a\u3044\u3002Encyclopedia\u3000\u5373\u3061\u767e\u79d1\u4e8b\u5178\u3067\u3042\u308b\u304b\u3089\u3001\u305d\u3046\u3057\u305f\u4f7f\u3044\u65b9\u304c\u6279\u5224\u3055\u308c\u308b\u308f\u3051\u3067\u306f\u306a\u3044\u3002\u3057\u304b\u3057\u306a\u304c\u3089\u3001\u5730\u9053\u306b\u9806\u3092\u8ffd\u3063\u3066\u898b\u3066\u3044\u304f\u3053\u3068\u3067\u3001\u4f55\u304b\u898b\u3064\u304b\u308b\u304b\u3082\u3057\u308c\u306a\u3044\u3053\u3068\u3092\u671f\u5f85\u3057\u3066\u9032\u3081\u308b\u3053\u3068\u306b\u3059\u308b\u3002<\/p>\n\n\n\n

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\"\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8<\/a><\/figure><\/div>\n\n\n\n

\u3000\u79c1\u306f\u30da\u30f3\u30c8\u30fc\u30b9\u30ea\u30f3\u9178\u7d4c\u8def\u3067\u4f5c\u3089\u308c\u308b\u30ea\u30dc\u30fc\u30b9-5-\u30ea\u30f3\u9178\u3092\u8d77\u70b9\u306b\u3057\u3066\u63cf\u3044\u3066\u307f\u305f\u3002\u3053\u306e\u56f3\u306b\u304a\u3044\u3066\u3001\u9752\u306e\u4e8c\u91cd\u7dda\u77e2\u5370\u304c\u8868\u306b\u51fa\u3066\u304f\u308b\u7d4c\u8def\u3067\u3042\u308a\u3001\u3053\u306e\u7dda\u306e\u6a2a\u306b\u5c11\u3057\u5c0f\u3055\u304f\u793a\u3057\u305f\u69cb\u9020\u5f0f\u7fa4\u304c\u3001\u305d\u3053\u3067\u8d77\u3053\u308b\u5316\u5b66\u53cd\u5fdc\u3092\u793a\u3057\u3066\u3044\u308b\u3002\u307e\u305f\u3001\u5404\u53cd\u5fdc\u3092\u89e6\u5a92\u3059\u308b\u9175\u7d20\u3092EC\u30ca\u30f3\u30d0\u30fc\u3067\u793a\u3057\u305f\u3002\u307e\u305a\u3001\u30ea\u30dc\u30fc\u30b95-\u30ea\u30f3\u9178\u306e1\u4f4d\u306e\u6c34\u9178\u57fa\u304cATP\u3068\u53cd\u5fdc\u3057\u30665-Phosphoribosyl 1-pyrophosphate\u3078\u3068\u5909\u63db\u3055\u308c\u308b\u3002\u306a\u3058\u307f\u6df1\u3044SN2\u53cd\u5fdc\u3067\u3042\u308b\u3002\u3053\u306e\u6642\u70b9\u30671\u4f4d\u306e\u6c34\u9178\u57fa\u306e\u8131\u96e2\u6027\u304c\u5411\u4e0a\u3057\u3053\u306e\u4f4d\u7f6e\u3067\u306e\u6c42\u6838\u7f6e\u63db\u53cd\u5fdc\u304c\u8d77\u3053\u308a\u3084\u3059\u304f\u306a\u308b\u3002\u3053\u3053\u3067\u30b0\u30eb\u30bf\u30df\u30f3\u306e\u30a2\u30df\u30c9\u304c\u52a0\u6c34\u5206\u89e3\u3092\u53d7\u3051\u3066\u751f\u6210\u3057\u305f\u30a2\u30f3\u30e2\u30cb\u30a2\u304c\u30015-Phosphoribosyl 1-pyrophosphate\u306e1\u4f4d\u3092\u653b\u6483\u3057\u3066\u30d4\u30ed\u30ea\u30f3\u9178\u306e\u8131\u96e2\u3092\u4f34\u30445-Phospho-D-ribosylamine\u3068\u306a\u308b\u3002\u307e\u3042\u3001\u30b0\u30eb\u30bf\u30df\u30f3\u306b\u5c5e\u3059\u308b\u30a2\u30df\u30ce\u57fa\u304c\u52a0\u308f\u3063\u305f\u306e\u3060\u304b\u3089\u30b0\u30eb\u30bf\u30df\u30f3\u304c\u51fa\u767a\u7269\u8cea\u3068\u8a00\u3048\u306a\u3044\u308f\u3051\u3067\u306f\u306a\u3044\u3002\u6b21\u306f5′-Phosphoribosylglycinamide\u3078\u306e\u5909\u63db\u3060\u304c\u3001\u307e\u305a\u30b0\u30ea\u30b7\u30f3\u306e\u30ab\u30eb\u30dc\u30ad\u30b7\u30eb\u57fa\u304cATP\u3068\u53cd\u5fdc\u3057\u3066\u6df7\u5408\u9178\u7121\u6c34\u7269\u306e\u4e2d\u9593\u4f53\u3092\u4f5c\u308b\u3002\u7ffb\u8a33\u306e\u6bb5\u968e\u3067\u8d77\u3053\u3063\u3066\u3044\u308b\u306e\u3068\u540c\u3058\u53cd\u5fdc\u3067\u3042\u308b\u3002\u3053\u306e\u9178\u7121\u6c34\u7269\u306e\u6d3b\u6027\u5316\u3055\u308c\u305f\u30ab\u30eb\u30dc\u30cb\u30eb\u57fa\u30925-Phospho-D-ribosylamine\u306e\u30a2\u30df\u30ce\u57fa\u304c\u653b\u6483\u3057\u3066\u3001\u76ee\u7684\u306e\u30a2\u30df\u30c9\u3092\u5f62\u6210\u3059\u308b\u3002\u3053\u306e\u6642\u30d5\u30ea\u30fc\u3068\u306a\u3063\u305f\u30b0\u30ea\u30b7\u30f3\u6b8b\u57fa\u306e\u30a2\u30df\u30ce\u57fa\u304c\u300110-Formyltetrahydrofolate\u304b\u3089\u30db\u30eb\u30df\u30eb\u57fa\u3092\u53d7\u3051\u53d6\u3063\u30665′-Phosphoribosyl-N-formylglycinamide\u304c\u5f62\u6210\u3055\u308c\u308b\u3002<\/p>\n\n\n\n

\u3000\u30ea\u30dc\u30fc\u30b95-\u30ea\u30f3\u9178\u304b\u30895-Phospho-D-ribosylamine\u307e\u3067\u306e2\u6bb5\u968e\u3092\u4e00\u6319\u306b\u9032\u3081\u308b\u53cd\u5fdc\u3082\u3042\u308b\u304c\u30011968\u5e74\u306b\u5831\u544a\u3055\u308c\u3066\u304b\u3089\u5f8c\u306b\u7d9a\u304f\u5831\u544a\u304c\u306a\u3044\u3002\u30b0\u30eb\u30bf\u30df\u30f3\u306e\u30a2\u30df\u30ce\u57fa\u3067\u306f\u306a\u304f\u76f4\u63a5\u30a2\u30f3\u30e2\u30cb\u30a2\u3092\u4f7f\u3046\u3068\u3044\u3046\u53cd\u5fdc\u3067\u9762\u767d\u3044\u3068\u306f\u601d\u3046\u3051\u308c\u3069\u6b86\u3069\u60c5\u5831\u304c\u306a\u3044\u306e\u304c\u6b8b\u5ff5\u3067\u3042\u308b\u3002<\/p>\n\n\n\n

\u3000\u6b21\u306b5′-Phosphoribosyl-N-formylglycinamide\u306e\u30a2\u30df\u30c9\u90e8\u5206\u304cATP\u3068\u306e\u53cd\u5fdc\u3067\u30a8\u30ce\u30fc\u30eb\u30ea\u30f3\u9178\u30a2\u30df\u30c9\u3068\u306a\u308b\u3053\u3068\u3067\u6d3b\u6027\u5316\u3055\u308c\u305f\u30b0\u30ea\u30b7\u30f3\u6b8b\u57fa\u306e1\u4f4d\u306e\u70ad\u7d20\u3092\u3001\u518d\u5ea6\u30b0\u30eb\u30bf\u30df\u30f3\u306e\u30a2\u30df\u30c9\u304c\u52a0\u6c34\u5206\u89e3\u3092\u53d7\u3051\u3066\u751f\u6210\u3057\u305f\u30a2\u30f3\u30e2\u30cb\u30a2\u304c\u6c42\u6838\u4ed8\u52a0\u3057\u305f\u5f8c\u3001\u6b63\u30ea\u30f3\u9178\u304c\u8131\u96e2\u3057\u3066\u3053\u306e\u30da\u30fc\u30b8\u306e\u6700\u7d42\u7523\u7269\u3068\u306a\u308b5′-Phosphoribosyl-N-formylglycinamidine\u304c\u751f\u5408\u6210\u3055\u308c\u308b\u3002\u3053\u306e\u56f3\u306b\u304a\u3044\u3066\u3001\u30b0\u30eb\u30bf\u30df\u30f3\u306f2\u3064\u306e\u53cd\u5fdc\u3092\u652f\u3048\u3066\u3044\u308b\u308f\u3051\u3060\u3002<\/p>\n\n\n\n

\u3000\u3053\u306e\u30da\u30fc\u30b8\u3092\u898b\u3066\u3044\u308b\u3068\u3001\u30b0\u30eb\u30bf\u30df\u30f3\u306e\u30a2\u30df\u30c9\u6b8b\u57fa\u306e\u52a0\u6c34\u5206\u89e3\u304c\u3001\u30a2\u30f3\u30e2\u30cb\u30a2\u3092\u51fa\u3059\u3068\u3044\u3046\u5358\u7d14\u306a\u53cd\u5fdc\u3067\u3042\u308b\u3068\u306f\u8a00\u3048\u751f\u7269\u306e\u907a\u4f1d\u7269\u8cea\u3067\u3042\u308b\u6838\u9178\u306e\u751f\u5408\u6210\u3092\u652f\u3048\u3066\u3044\u308b\u4e8b\u5b9f\u3092\u518d\u78ba\u8a8d\u305b\u3056\u308b\u3092\u5f97\u306a\u3044\u3002\u66f4\u306b\u3001ATP\u304c\u6c34\u9178\u57fa\u3001\u6216\u3044\u306f\u30ab\u30eb\u30dc\u30ad\u30b7\u30eb\u57fa\u306e\u6c34\u9178\u57fa\u3092\u30ea\u30f3\u9178\u5316\u3059\u308b\u53cd\u5fdc\u306e\u5927\u4e8b\u3055\u3067\u3042\u308b\u30025\u6bb5\u968e\u306e\u53cd\u5fdc\u306e\u3046\u3061\u30013\u6bb5\u968e\u3067\u3053\u306e\u3084\u308a\u65b9\u3067ATP\u304c\u4f7f\u308f\u308c\u3066\u3044\u308b\u3002\u307e\u305f\u3001\u751f\u7269\u304cDNA\u3082\u3057\u304f\u306fRNA\u3092\u4f7f\u3044\u59cb\u3081\u305f\u3068\u304d\u3001\u8449\u9178\u3092\u88dc\u9175\u7d20\u3068\u3059\u308b1\u70ad\u7d20\u8ee2\u79fb\u53cd\u5fdc\u304c\u6210\u7acb\u3057\u3066\u3044\u305f\u3053\u3068\u3082\u63a8\u6e2c\u3067\u304d\u308b\u3002<\/p>\n\n\n\n

\u3000\u6b21\u306e\u56f3\u306b\u79fb\u308b\u3002\u3053\u306e\u56f3\u306f\u524d\u56f3\u306e\u6700\u7d42\u7523\u7269\u3067\u3042\u308b 5′-Phosphoribosyl-N-formylglycinamidine\u304b\u30891-(5′-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole\u307e\u3067\u306e\u53cd\u5fdc\u3092\u793a\u3057\u3066\u3044\u308b\u3002<\/p>\n\n\n\n

\"\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8<\/a><\/figure><\/div>\n\n\n\n

\u3000\u307e\u305a\u30011-(5′-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole\u306e\u30db\u30eb\u30e0\u30a2\u30df\u30c9\u90e8\u5206\u304c\u30a8\u30ce\u30fc\u30eb\u30ea\u30f3\u9178\u3068\u306a\u3063\u3066\u30ab\u30eb\u30dc\u30cb\u30eb\u70ad\u7d20\u306e\u6d3b\u6027\u5316\u304c\u8d77\u3053\u3063\u305f\u5f8c\u3001\u3053\u306e\u70ad\u7d20\u539f\u5b50\u3092\u30d5\u30e9\u30f3\u74b0\u306b\u3064\u3044\u305f2\u7d1a\u30a2\u30df\u30f3\u306e\u7a92\u7d20\u539f\u5b50\u304c\u653b\u6483\u3057\u3001\u8131\u30ea\u30f3\u9178\u3092\u4f34\u3063\u3066\u30a4\u30df\u30c0\u30be\u30fc\u30eb\u74b0\u304c\u751f\u6210\u3059\u308b\u3002\u8eab\u8fd1\u306b\u30d8\u30c6\u30ed\u74b0\u3092\u5408\u6210\u3057\u3066\u3044\u305f\u4eba\u304c\u4f55\u4eba\u3082\u3044\u305f\u306e\u3067\u3001\u305d\u306e\u3046\u3061\u4f59\u308a\u6c17\u306b\u306a\u3089\u306a\u304f\u306a\u3063\u305f\u3068\u306f\u3044\u3048\u3001\u79c1\u306e\u7d4c\u9a13\u3067\u306f\u30d8\u30c6\u30ed\u74b0\u306e\u53cd\u5fdc\u306f\u306a\u3093\u3068\u306a\u304f\u308f\u304b\u308a\u306b\u304f\u304b\u3063\u305f\u8a18\u61b6\u304c\u3042\u308b\u3002\u6b21\u306e\u53cd\u5fdc\u306f\u5358\u306a\u308b\u30ab\u30eb\u30dc\u30ad\u30b7\u30eb\u304b\u53cd\u5fdc\u3060\u304c\u3001\u305d\u306e\u7d4c\u8def\u306f\u4e00\u5bf8\u9762\u5012\u3067\u3042\u308b\u3002\u70ad\u9178\u30a4\u30aa\u30f3\u304cATP\u3068\u53cd\u5fdc\u3057\u3066\u6df7\u5408\u9178\u7121\u6c34\u7269\u3067\u3042\u308bcarbonic phosphoric anhydride\u3078\u3068\u6d3b\u6027\u5316\u3055\u308c\u305f\u5f8c\u3001\u3053\u306e\u30ab\u30eb\u30dc\u30cb\u30eb\u57fa\u3092\u30a4\u30df\u30c0\u30be\u30fc\u30eb\u611f\u60c5\u306e\u30a2\u30df\u30ce\u57fa\u304c\u653b\u6483\u3057\u3066\u30ab\u30eb\u30d0\u30df\u30f3\u9178\u3092\u5f62\u6210\u3059\u308b\u304c\u3001\u30ab\u30eb\u30d0\u30df\u30f3\u9178\u306f\u4e0d\u5b89\u5b9a\u3067\u3042\u308b\u305f\u3081\u3059\u3050\u306b\u8131\u70ad\u9178\u304c\u8d77\u3053\u308a\u3001\u4e8c\u9178\u5316\u70ad\u7d20\u304c\u8131\u96e2\u3059\u308b\u3068\u540c\u6642\u306b\u30a4\u30df\u30c0\u30be\u30fc\u30eb\u74b0\u306e4\u4f4d\u306b\u30a2\u30cb\u30aa\u30f3\u304c\u767a\u751f\u3059\u308b\u3002\u3053\u306e\u30a2\u30cb\u30aa\u30f3\u304c\u305d\u3070\u306b\u3042\u3063\u305f\u4e8c\u9178\u5316\u70ad\u7d20\u3068\u53cd\u5fdc\u3057\u305f\u5f8c\u3001\u74b0\u306e\u518d\u82b3\u9999\u5316\u304c\u8d77\u3053\u308a1-(5′-Phosphoribosyl)-5-amino-4-imidazolecarboxylate\u304c\u751f\u6210\u3059\u308b\u3002\u3053\u306e\u53cd\u5fdc\u306b\u304a\u3051\u308b\u30a2\u30df\u30ce\u57fa\u306e\u53cd\u5fdc\u69d8\u5f0f\u306f\u3001\u306a\u3093\u3068\u306a\u304f\u8fc2\u9060\u306a\u6c17\u304c\u3059\u308b\u304c\u3001\u30d3\u30aa\u30c1\u30f3\u3092\u88dc\u9175\u7d20\u3068\u3059\u308b\u30ab\u30eb\u30dc\u30ad\u30b7\u30eb\u5316\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u3068\u540c\u3058\u3067\u3042\u308b\u3002\u521d\u3081\u304b\u3089\u3001\u30a4\u30df\u30c0\u30be\u30fc\u30eb\u306e4\u4f4d\u306b\u30a2\u30cb\u30aa\u30f3\u3092\u767a\u751f\u3055\u305b\u308b\u5171\u9cf4\u69cb\u9020\u3092\u63cf\u3051\u306a\u3044\u308f\u3051\u3067\u306f\u306a\u3044\u304c\u3001\u30a4\u30df\u30c0\u30be\u30fc\u30eb\u74b0\u306f\u82b3\u9999\u65cf\u6027\u3092\u6301\u3064\u3002\u5f93\u3063\u3066\u3001\u3053\u306e\u30a2\u30cb\u30aa\u30f3\u306e\u5bc4\u4e0e\u304c\u975e\u5e38\u306b\u5c0f\u3055\u3044\u304c\u6545\u306b\u3001\u3053\u3046\u3057\u305f\u7d4c\u8def\u304c\u9078\u3070\u308c\u305f\u306e\u3060\u308d\u3046\u3002<\/p>\n\n\n\n

\u3000\u6b21\u306e\u53cd\u5fdc\u3082ATP\u306b\u3088\u308b\u30ab\u30eb\u30dc\u30ad\u30b7\u30eb\u57fa\u306e\u6d3b\u6027\u5316\u304b\u3089\u59cb\u307e\u308b\u3002\u3053\u3053\u3067\u751f\u6210\u3057\u305f\u6df7\u5408\u9178\u7121\u6c34\u7269\u304c\u3001TCA\u30b5\u30a4\u30af\u30eb\u306e\u69cb\u6210\u6210\u5206\u3067\u3042\u308b\u30aa\u30ae\u30b6\u30ed\u9162\u9178\u306e\u30a2\u30df\u30ce\u57fa\u8ee2\u79fb\u7523\u7269\u3067\u3042\u308b\u3044\u307e\u4e00\u3064\u306e\u306e\u30a2\u30df\u30ce\u57fa\u306b\u3088\u308b\u653b\u6483\u3092\u53d7\u3051\u3066\u3001\u3053\u306e\u30da\u30fc\u30b8\u306e\u6700\u7d42\u7523\u7269\u3067\u3042\u308b1-(5′-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole\u304c\u751f\u6210\u3059\u308b\u3002\u5b98\u80fd\u57fa\u3092\u6d3b\u6027\u5316\u3059\u308b\u5f79\u5272\u3067ATP\u304c\u7e26\u6a2a\u7121\u5c3d\u306b\u6d3b\u8e8d\u3057\u3066\u3044\u308b\u306e\u304c\u5370\u8c61\u7684\u3067\u3042\u308b\u3002<\/p>\n\n\n\n

\u3000\u3055\u3066\u3001\u4eca\u56de\u306f\u6b21\u306e\u56f3\u307e\u3067\u3067\u4e00\u65e6\u6b62\u3081\u3088\u3046\u3002<\/p>\n\n\n\n

\"\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8<\/a><\/figure><\/div>\n\n\n\n

\u3000\u5148\u306e\u56f3\u306b\u304a\u3051\u308b\u6700\u7d42\u7523\u7269\u3067\u3042\u3063\u305f1-(5′-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole\u304b\u3089\u30d5\u30de\u30eb\u9178\u304c\u8131\u96e2\u3059\u308b\u30685′-Phosphoribosyl-5-amino-4-imidazolecarboxamide\u304c\u4f5c\u3089\u308c\u308b\u30024\u4f4d\u306e\u30ab\u30eb\u30dc\u30ad\u30b7\u30eb\u57fa\u3092\u30a2\u30df\u30c9\u3068\u3059\u308b\u305f\u3081\u306b\u306a\u3093\u3068\u9060\u56de\u308a\u306a\u53cd\u5fdc\u3092\u4f7f\u3046\u306e\u3060\u308d\u3046\u3068\u6238\u60d1\u3044\u3092\u611f\u3058\u308b\u3002\u3053\u3053\u306b\u3082\u3001\u30b0\u30eb\u30bf\u30df\u30f3\u304b\u3089\u306e\u30a2\u30df\u30ce\u57fa\u3092\u4f7f\u3048\u3070\u826f\u3044\u306e\u306b\u3068\u601d\u3046\u308f\u3051\u3060\u3002\u3057\u304b\u3057\u306a\u304c\u3089\u3001\u5b9f\u969b\u304c\u305d\u3046\u306a\u3063\u3066\u3044\u308b\u306e\u3060\u304b\u3089\u4ed5\u65b9\u304c\u306a\u3044\u3002<\/p>\n\n\n\n

\u3000\u6b21\u306e\u53cd\u5fdc\u306f\u30a4\u30df\u30c0\u30be\u30fc\u30eb\u74b05\u4f4d\u306b\u3042\u308b\u30a2\u30df\u30ce\u57fa\u306e\u30db\u30eb\u30df\u30eb\u5316\u306a\u306e\u3060\u304c\u3001\u30e1\u30ab\u30cb\u30ba\u30e0\u306f10-Formyltetrahydrofolate\u3092\u30db\u30eb\u30df\u30eb\u57fa\u306e\u7d66\u6e90\u3068\u3059\u308b 5′-Phosphoribosylglycinamide\u306e\u5834\u5408\u3068\u540c\u3058\u3067\u3042\u308b\u3002\u56f3\u306b\u304a\u3044\u3066\u306f\u5f8c\u3067\u8d77\u3053\u308b\u30d4\u30ea\u30df\u30b8\u30f3\u74b0\u306e\u65b9\u5411\u3068\u5408\u308f\u305b\u308b\u305f\u3081\u306b\u3001\u30a4\u30df\u30c0\u30be\u30fc\u30eb\u74b0\u3092180\u5ea6\u56de\u8ee2\u3055\u305b\u3066\u8868\u8a18\u3057\u3066\u3044\u308b\u30021-(5′-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide\u304b\u3089Inosine 5′-monophosphate\u3078\u306e\u9589\u74b0\u53cd\u5fdc\u306f\u3001\u30a4\u30df\u30c0\u30be\u30fc\u30eb\u74b0\u5f62\u6210\u53cd\u5fdc\u3068\u540c\u3058\u3088\u3046\u306b\u9032\u884c\u3057\u305d\u3046\u306b\u601d\u3048\u308b\u304c\u3001\u6b8b\u5ff5\u306a\u304c\u3089\u305d\u3046\u3067\u306f\u306a\u3044\u3002\u3053\u306e\u53cd\u5fdc\u3067\u306fATP\u306b\u3088\u308b\u6d3b\u6027\u5316\u3092\u7d4c\u305a\u306b\u8131\u6c34\u3092\u4f34\u3046\u9589\u74b0\u304c\u8d77\u3053\u308aInosine 5′-monophosphate\u304c\u5f62\u6210\u3055\u308c\u308b\u3002<\/p>\n\n\n\n

\u3000\u3053\u306e2\u6bb5\u968e\u306e\u53cd\u5fdc\u306f5-amino-4-imidazolecarboxamide ribonucleotide transformylase [EC\uff1a2.1.2.3] \u306b\u3088\u3063\u3066\u4e00\u6319\u306b\u9032\u884c\u3059\u308b\u306e\u3060\u304c\u3001\u3053\u306e\u9175\u7d20\u306f\u771f\u6838\u751f\u7269\u3001\u30d0\u30af\u30c6\u30ea\u30a2\u306b\u5206\u5e03\u3057\u3001\u53e4\u7d30\u83cc\u3067\u306e\u5206\u5e03\u306f\u72ed\u3044\u3002\u6700\u521d\u306e\u30db\u30eb\u30df\u30eb\u5316\u3092\u89e6\u5a92\u3059\u308b\u3044\u307e\u4e00\u3064\u306e\u9175\u7d20 5-formaminoimidazole-4-carboxamide-1-(beta)-D-ribofuranosyl 5′-monophosphate synthetase [EC:6.3.4.23]\u306f\u53e4\u7d30\u83cc\u306b\u304a\u3044\u3066\u5e83\u304f\u5206\u5e03\u3057\u3001\u30d0\u30af\u30c6\u30ea\u30a2\u306e\u4e00\u90e8\u306b\u3082\u5b58\u5728\u3059\u308b\u3002\u6b21\u306e\u9589\u74b0\u53cd\u5fdc\u3092\u89e6\u5a92\u3059\u308b\u3082\u3046\u4e00\u3064\u306e\u9175\u7d20\u3067\u3042\u308b  Inosine 5′-monophosphate cyclohydrolase [EC:3.5.4.10] \u306f\u3001\u539f\u6838\u751f\u7269\u30fb\u771f\u6838\u751f\u7269\u3092\u554f\u308f\u305a\u5e83\u304f\u5206\u5e03\u3057\u3066\u3044\u308b\u3002\u3060\u304b\u3089\u3069\u3046\u3060\u3068\u3044\u3046\u8a71\u306b\u306f\u306a\u3089\u306a\u3044\u304c\u3001\u4f55\u3089\u304b\u306e\u771f\u5b9f\u304c\u7d30\u90e8\u306b\u5bbf\u3063\u3066\u3044\u308b\u306e\u3067\u3042\u308d\u3046\u3002<\/p>\n\n\n\n

\u3000\u30d7\u30ea\u30f3\u5869\u57fa\u306e\u751f\u5408\u6210\u7cfb\u306f\u3001\u3053\u3053\u3067\u30a2\u30c7\u30cb\u30f3\u74b0\u3092\u6301\u3064ATP\u3001\uff44ATP\u3078\u3068\u5411\u304b\u3046\u6d41\u308c\u3068\u3001\u30b0\u30a2\u30cb\u30f3\u74b0\u3092\u6301\u3064GTP\u3001\uff44GTP\u3078\u5411\u304b\u3046\u6d41\u308c\u306b\u5206\u5c90\u3059\u308b\u3053\u3068\u306b\u306a\u308b\u3002<\/p>\n\n\n\n

\u904e\u5270\u3068\u8569\u5c3d\u300030\u3000\u306b\u7d9a\u304f<\/p>\n","protected":false},"excerpt":{"rendered":"

\u3000\u3067\u306f\u307e\u305a\u3001\u30d7\u30ea\u30f3\u5869\u57fa\u306e\u751f\u5408\u6210\u304b\u3089\u59cb\u3081\u308b\u3053\u3068\u306b\u3059\u308b\u3002\u51fa\u767a\u306f\u524d\u56de\u307e\u3067\u8b70\u8ad6\u3057\u3066\u304d\u305f\u30b0 … \u7d9a\u304d\u3092\u8aad\u3080 →<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-5623","post","type-post","status-publish","format-standard","hentry","category-1"],"_links":{"self":[{"href":"https:\/\/bamboolab.yamasatoagr.com\/index.php?rest_route=\/wp\/v2\/posts\/5623","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/bamboolab.yamasatoagr.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/bamboolab.yamasatoagr.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/bamboolab.yamasatoagr.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/bamboolab.yamasatoagr.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=5623"}],"version-history":[{"count":1,"href":"https:\/\/bamboolab.yamasatoagr.com\/index.php?rest_route=\/wp\/v2\/posts\/5623\/revisions"}],"predecessor-version":[{"id":5624,"href":"https:\/\/bamboolab.yamasatoagr.com\/index.php?rest_route=\/wp\/v2\/posts\/5623\/revisions\/5624"}],"wp:attachment":[{"href":"https:\/\/bamboolab.yamasatoagr.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=5623"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/bamboolab.yamasatoagr.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=5623"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/bamboolab.yamasatoagr.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=5623"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}