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\u304b\u3089\u30b0\u30eb\u30bf\u30df\u30f3\u3078\u5909\u63db\u3055\u308c\u305f\u5f8c\u3001\u30a2\u30df\u30c9\u57fa\u306e\u30a2\u30df\u30ce\u6b8b\u57fa\u304c 5-Phospho-\u03b1-D-ribose -1-diphosphate \u306e1\u4f4d\u306b\u5c0e\u5165\u3055\u308c\u30015-Phosphoribosylamine\u3068\u306a\u3063\u305f\u5f8c\u3044\u308f\u3086\u308b\u30d7\u30ea\u30f3\u4ee3\u8b1d\u7cfb\u306b\u3064\u306a\u304c\u3063\u3066\u3044\u304f\u3002\u30d4\u30ea\u30df\u30b8\u30f3\u4ee3\u8b1d\u7cfb\u3082\u30b0\u30eb\u30bf\u30df\u30f3\u304b\u3089\u5206\u5c90\u3059\u308b\u3002\u53cd\u5fdc\u306b\u3064\u3044\u3066\u306f\u5f8c\u8ff0\u3059\u308b\u3068\u3057\u3066\u3001\u30b0\u30eb\u30bf\u30df\u30f3\u306e\u30a2\u30df\u30c9\u57fa\u306e\u30a2\u30df\u30ce\u6b8b\u57fa\u3092\u542b\u3080 Carbamoyl phosphate \u304c\u30a2\u30b9\u30d1\u30e9\u30ae\u30f3\u9178\u3068\u53cd\u5fdc\u3057\u3066N-Carbamoyl-L-aspartate\u3068\u306a\u308a\u30d4\u30ea\u30df\u30b8\u30f3\u4ee3\u8b1d\u7cfb\u3078\u3068\u6d41\u308c\u3066\u3044\u304f\u3002\u3053\u306e\u4ee3\u8b1d\u3067\u751f\u5408\u6210\u3055\u308c\u308b\u306e\u306f\u30ea\u30dc\u30fc\u30b9\u6b8b\u57fa\u3092\u542b\u3080ATP\u3001GTP\u3001CTP\u3001UTP\u3067\u3042\u308a\u3001\u30c7\u30aa\u30ad\u30b7\u30ea\u30dc\u30fc\u30b9\u6b8b\u57fa\u3092\u3082\u3064dATP\u3001dGTP\u3001dCTP\u3001dTTP\u306f\u5bfe\u5fdc\u3059\u308b\u30ea\u30dc\u30cc\u30af\u30ec\u30aa\u30c1\u30c9\u304b\u3089\u751f\u5408\u6210\u3055\u308c\u308b\u3002\u3053\u306e\u9806\u5e8f\u304b\u3089\u898b\u3066\u3001\u751f\u7269\u754c\u3067RNA\u304cDNA\u306b\u5148\u884c\u3059\u308b\u306e\u306f\u81ea\u660e\u306e\u8a71\u3068\u306a\u308b\u3002<\/p>\n\n\n\n<p>\u3000\u3055\u3066\u3001\u3053\u308c\u304b\u3089\u5e7e\u5206\u4ee5\u4e0a\u306b\u9762\u5012\u306a\u6838\u9178\u306e\u751f\u5408\u6210\u7cfb\u3092\u3058\u3063\u304f\u308a\u3068\u898b\u3066\u3044\u304f\u308f\u3051\u3060\u304c\u3001\u5b9f\u306f\u3053\u306e\u7cfb\u306e\u524d\u90e8\u306b\u95a2\u3057\u3066\u306f\u8b70\u8ad6\u306f\u7d42\u308f\u3063\u3066\u3044\u308b\u3002\u3064\u307e\u308a\u3001\u300cTCA\u56de\u8def\u306e\u89e3\u91c8\u306f\u9593\u9055\u3063\u3066\u3044\u308b\u300d\u306e\u4e2d\u3067\u30a2\u30bb\u30c1\u30ebCoA\u304b\u30892-\u30aa\u30af\u30bd\u30b0\u30eb\u30bf\u30eb\u9178\u307e\u3067\u306e\u5909\u63db\u306b\u3064\u3044\u3066\u306f\u3059\u3067\u306b\u8ff0\u3079\u3066\u3044\u308b\u304b\u3089\u3060\u3002\u8208\u5473\u306e\u3042\u308b\u65b9\u306f\u305d\u3061\u3089\u3092\u53c2\u7167\u3057\u3066\u307b\u3057\u3044\u3002\u5f93\u3063\u3066\u5b9f\u969b\u306e\u53cd\u5fdc\u306b\u95a2\u3059\u308b\u8aac\u660e\u306f2-\u30aa\u30af\u30bd\u30b0\u30eb\u30bf\u30eb\u9178\u304b\u3089\u59cb\u307e\u308b\u4e8b\u306b\u306a\u308b\u3002<\/p>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"aligncenter\"><a href=\"http:\/\/bamboolab.ok-japan.com\/?attachment_id=3809\" rel=\"attachment wp-att-3809\"><img decoding=\"async\" src=\"http:\/\/bamboolab.ok-japan.com\/wp-content\/uploads\/2016\/12\/\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8-2016-12-22-19.28.55.png\" alt=\"\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8 2016-12-22 19.28.55\" class=\"wp-image-3809\"\/><\/a><figcaption>2-\u30aa\u30af\u30bd\u30b0\u30eb\u30bf\u30eb\u9178\u304b\u3089\u30b0\u30eb\u30bf\u30df\u30f3\u9178\u306e\u751f\u5408\u6210<\/figcaption><\/figure><\/div>\n\n\n\n<p>\u3000\u751f\u7269\u306b\u3068\u3063\u3066\u3001\u6975\u3081\u3066\u5927\u4e8b\u306a\u53cd\u5fdc\u3067\u3042\u308b2-\u30aa\u30af\u30bd\u30b0\u30eb\u30bf\u30eb\u9178\u304b\u3089\u306eL-\u30b0\u30eb\u30bf\u30df\u30f3\u9178\u306e\u751f\u5408\u6210\u306f\u3001\u6709\u6a5f\u5316\u5b66\u7684\u306b\u898b\u308c\u3070\u3055\u307b\u3069\u96e3\u3057\u3044\u53cd\u5fdc\u3067\u306f\u306a\u3044\u30022-\u30aa\u30af\u30bd\u30b0\u30eb\u30bf\u30eb\u9178\u306e2\u4f4d\u306e\u30ab\u30eb\u30dc\u30cb\u30eb\u57fa\u3068\u30a2\u30f3\u30e2\u30cb\u30a2\u304c\u8131\u6c34\u53cd\u5fdc\u3092\u8d77\u3053\u3057\u3066\u30b7\u30c3\u30d5\u5869\u57fa\u3068\u306a\u3063\u305f\u5f8c\u3001NADH\u3042\u308b\u3044\u306fNADPH\u3092\u7d66\u6e90\u3068\u3059\u308b\u30cf\u30a4\u30c9\u30e9\u30a4\u30c9\u30a4\u30aa\u30f3\u304c2\u4f4d\u306e\u70ad\u7d20\u3092\u653b\u6483\u3057\u3066\u30b0\u30eb\u30bf\u30df\u30f3\u9178\u3068\u306a\u308b\u3002\u3053\u306e\u6642\u30012\u4f4d\u306e\u70ad\u7d20\u306ere\u9762\u5074\u304b\u3089\u653b\u6483\u304c\u8d77\u3053\u308c\u3070D-Glu\u304csi\u9762\u5074\u304b\u3089\u653b\u6483\u304c\u8d77\u3053\u308c\u3070L-Glu\u304c\u751f\u6210\u3059\u308b\u3053\u3068\u306b\u306a\u308b\u3002\u3082\u3061\u308d\u3093\u3001\u307b\u307c\u5168\u3066\u306e\u751f\u7269\u306b\u304a\u3044\u3066\u306fsi\u9762\u5074\u304b\u3089\u653b\u6483\u304c\u512a\u5148\u7684\u306b\u8d77\u3053\u308b\u3053\u3068\u306f\u8af8\u6c0f\u3082\u3054\u5b58\u77e5\u306e\u901a\u308a\u3067\u3042\u308b\u3002\u305d\u3057\u3066\u3001\u6211\u3005\u306e\u4f53\u3092\u69cb\u6210\u3059\u308b\u591a\u304f\u306e\u30a2\u30df\u30ce\u9178\u751f\u5408\u6210\u306f\u3053\u306e\u53cd\u5fdc\u304b\u3089\u59cb\u307e\u308b\u306e\u3067\u3042\u308b\u3002<\/p>\n\n\n\n<p>\u3000\u3053\u3053\u3067\u554f\u984c\u306b\u306a\u308b\u306e\u306f\u53cd\u5fdc\u3067\u4f7f\u308f\u308c\u308b\u30a2\u30f3\u30e2\u30cb\u30a2\u306e\u8d77\u6e90\u3067\u3042\u308b\u30022-\u30aa\u30af\u30bd\u30b0\u30eb\u30bf\u30eb\u9178\u304b\u3089\u306eL-\u30b0\u30eb\u30bf\u30df\u30f3\u9178\u306e\u751f\u5408\u6210\u3092\u89e6\u5a92\u3059\u308b\u9175\u7d20\u306f\u3001glutamate dehydrogenase\u3068\u547c\u3070\u308c\u308b\u7d30\u80de\u5185\u306b\u5b58\u5728\u3059\u308b\u7a92\u7d20\u4ee3\u8b1d\u7cfb\u306b\u7531\u6765\u3059\u308b\u30a2\u30f3\u30e2\u30cb\u30a2\u3092\u57fa\u8cea\u3068\u3059\u308b\u9175\u7d20\u7fa4\u3068\u3001glutamate synthase\u3068\u547c\u3070\u308c\u308bL-\u30b0\u30eb\u30bf\u30df\u30f3\u306e\u30a2\u30df\u30c9\u306b\u7531\u6765\u3059\u308b\u30a2\u30f3\u30e2\u30cb\u30a2\u3092\u57fa\u8cea\u3068\u3059\u308b\u9175\u7d20\u7fa4\u3067\u3042\u308b\u3002\u5f8c\u8005\u306e\u7cfb\u306b\u304a\u3044\u3066\u306f L-\u30b0\u30eb\u30bf\u30df\u30f3\u306f L-\u30b0\u30eb\u30bf\u30df\u30f3\u9178\u306b\u7531\u6765\u3059\u308b\u305f\u3081\u3001\u3053\u306e\u7cfb\u3092\u521d\u767a\u306e\u30b0\u30eb\u30bf\u30df\u30f3\u9178\u751f\u5408\u6210\u7cfb\u3068\u3057\u3066\u6349\u3048\u308b\u3053\u3068\u306f\u5c11\u3057\u7121\u7406\u304c\u3042\u308b\u304b\u306a\u3068\u601d\u3046\u306e\u3060\u304c\u3001\u539f\u521d\u306e\u751f\u7269\u304c\u30d8\u30c6\u30ed\u30c8\u30ed\u30d5\u5373\u3061\u5f93\u5c5e\u6804\u990a\u751f\u7269\u3067\u3042\u3063\u305f\u3068\u3059\u308c\u3070\u3001\u3053\u306e\u53ef\u80fd\u6027\u3082\u5f37\u3061\u5426\u5b9a\u3067\u304d\u308b\u308f\u3051\u3067\u3082\u306a\u3044\u304c\u305d\u306e\u53ef\u80fd\u6027\u306f\u9650\u308a\u306a\u304f\u5c0f\u3055\u3044\u3067\u3042\u308d\u3046\u3002\u3055\u3066\u300116S rRNA\u3092\u57fa\u306b\u3057\u305f\u7cfb\u7d71\u6a39\u306b\u304a\u3044\u3066\u3001\u597d\u71b1\u6027\u30d0\u30af\u30c6\u30ea\u30a2 Aquifex\u3001Thermotoga\u3001Green filament bacteria\u3001\u53e4\u7d30\u83cc\u3067\u3042\u308b Pyrodicticum\u3001Thermoproteus \u306e\u4ef2\u9593\u306f\u3001\u6839\u5143\u306b\u8fd1\u3044\u3068\u3053\u308d\u306b\u6839\u3063\u3053\u3092\u6301\u3064\u597d\u71b1\u6027\u306e\u5fae\u751f\u7269\u7fa4\u3067\u3042\u308b\u3002 \u3053\u3053\u3067\u554f\u984c\u306b\u3057\u3066\u3044\u308b\u30b0\u30eb\u30bf\u30df\u30f3\u9178\u751f\u5408\u6210\u306b\u95a2\u3059\u308b2\u7a2e\u306e\u9175\u7d20\u306b\u3064\u3044\u3066\u3001\u3053\u308c\u3089\u306e\u5fae\u751f\u7269\u3067\u306e\u5206\u5e03\u3092\u898b\u3066\u307f\u308b\u3068\u4ee5\u4e0b\u306b\u793a\u3057\u305f\u8868\u306e\u3088\u3046\u306b\u306a\u308b\u3002<\/p>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"aligncenter\"><a href=\"http:\/\/bamboolab.ok-japan.com\/?attachment_id=3811\" rel=\"attachment wp-att-3811\"><img decoding=\"async\" src=\"http:\/\/bamboolab.ok-japan.com\/wp-content\/uploads\/2016\/12\/\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8-2016-12-22-20.59.02.png\" alt=\"\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8 2016-12-22 20.59.02\" class=\"wp-image-3811\"\/><\/a><figcaption>\uff08\u7dd1\u306b\u5857\u3063\u305f\u90e8\u5206\u306e\u9175\u7d20\u304c\u5b58\u5728\u3059\u308b\uff09<\/figcaption><\/figure><\/div>\n\n\n\n<p>\u597d\u71b1\u6027\u7d30\u83cc\u3067\u3042\u308b&#8221;<em>Aquifex aeolicus<\/em>&#8220;\u3092\u542b\u3080Aquificae\u79d1\u306b\u5c5e\u3059\u308b14\u7a2e\u306e\u597d\u71b1\u83cc\u6027\u7d30\u83cc\u306e\u4e2d\u3067\u3001\u4ee5\u4e0b\u306b\u793a\u3059\u3088\u3046\u306b12\u7a2e\u306fL-\u30b0\u30eb\u30bf\u30df\u30f3\u306e\u30a2\u30df\u30c9\u306b\u7531\u6765\u3059\u308b\u30a2\u30f3\u30e2\u30cb\u30a2\u3092\u57fa\u8cea\u3068\u3059\u308bglutamate synthase\u306e\u307f\u3092\u6301\u3064\u3002\u6b8b\u308a\u306e2\u7a2e\u985e\u306e\u5fae\u751f\u7269\u3001<em>Sulfurihydrogenibium azorense\u3068Thermosulfidibacter takaii<\/em>\u306f\u4e0a\u8a18\u306eglutamate synthase \u3068\u3068\u3082\u306b\u3001\u30b0\u30eb\u30bf\u30df\u30f3\u3092\u5fc5\u8981\u3068\u3057\u306a\u3044glutamate dehydrogenase\u3092\u4f75\u305b\u6301\u3063\u3066\u3044\u308b<\/p>\n\n\n\n<p>Thermotogae\u79d127\u7a2e\u306e\u5185\u8a33\u3092\u307f\u308b\u3068Thermotoga\u5c5e\u306e13\u7a2e\u306f\u5168\u3066\u3092\u542b\u308024\u7a2e\u306e\u7d30\u83cc\u306fglutamate dehydrogenase\u3068\u3068\u3082\u306bglutamate synthase\u3092\u6301\u3063\u3066\u3044\u308b\u3002\u3053\u306e\u30b0\u30eb\u30fc\u30d7\u306e\u4e2d\u3067\u6c17\u306b\u306a\u308b\u306e\u306f<em>Defluviitoga tunisiensis<\/em>\u3068<em>Thermodesulfobacterium commune<\/em>\u3067\u3042\u308d\u3046\u3002\u524d\u8005\u306fglutamine synthetase\u3092\u6b20\u3044\u3066\u3044\u308b\u70b9\u3067\u30e6\u30cb\u30fc\u30af\u3067\u3042\u308a\u3001\u5f8c\u8005\u306f\u30b0\u30eb\u30bf\u30df\u30f3\u9178\u5408\u6210\u9175\u7d20\u7fa4\u3092\u6b20\u3044\u3066\u3044\u308b\u306b\u3082\u304b\u304b\u308f\u3089\u305a\u30b0\u30eb\u30bf\u30df\u30f3\u9178\u304b\u3089\u30b0\u30eb\u30bf\u30df\u30f3\u3092\u5408\u6210\u3059\u308b\u9175\u7d20\u306f\u6301\u3064\u3002<\/p>\n\n\n\n<p>\u3082\u3046\u4e00\u3064\u3001\u7cfb\u7d71\u6a39\u306e\u6df1\u3044\u4f4d\u7f6e\u306b\u5206\u5c90\u70b9\u3092\u6301\u3064\u30b0\u30eb\u30fc\u30d7\u3067\u3042\u308bGreen filament bacteria\u306f\u3001\u7dd1\u8272\u975e\u30a4\u30aa\u30a6\u7d30\u83cc\u3068\u3082\u547c\u3070\u308c\u308b\u30b0\u30eb\u30fc\u30d7\u3067 \u300110\u5c5e 25\u7a2e\u306e\u7d30\u83cc\u3092\u542b\u3080\u304c\u3001\u3053\u306e\u30b0\u30eb\u30fc\u30d7\u306e\u4e2d\u306b\u3082\u5909\u308f\u308a\u8005\u306f\u3044\u308b\u3002<\/p>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"aligncenter\"><a href=\"http:\/\/bamboolab.ok-japan.com\/?attachment_id=3812\" rel=\"attachment wp-att-3812\"><img decoding=\"async\" src=\"http:\/\/bamboolab.ok-japan.com\/wp-content\/uploads\/2016\/12\/\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8-2016-12-22-20.59.31.png\" alt=\"\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8 2016-12-22 20.59.31\" class=\"wp-image-3812\"\/><\/a><figcaption>\uff08\u7dd1\u306b\u5857\u3063\u305f\u90e8\u5206\u306e\u9175\u7d20\u304c\u5b58\u5728\u3059\u308b\uff09<\/figcaption><\/figure><\/div>\n\n\n\n<p>\u3000Dehalococcoides\u3001Dehalogenimonas\u3001Sphaerobacterineae\u305d\u3057\u3066Caldilinea\u306b\u5c5e\u3059\u308b\u7d30\u83cc\u7fa4\u306f\u30b0\u30eb\u30bf\u30df\u30f3\u9178\u751f\u5408\u6210\u9175\u7d20\u3092\u6b20\u3044\u3066\u3044\u308b\u306b\u3082\u304b\u304b\u308f\u3089\u305a\u3001\u30b0\u30eb\u30bf\u30df\u30f3\u9178\u304b\u3089\u30b0\u30eb\u30bf\u30df\u30f3\u3092\u5408\u6210\u3059\u308b\u9175\u7d20\u306f\u6301\u3064\u3002<em>Anaerolineaceae bacterium oral taxon 439<\/em>\u306f\u30b0\u30eb\u30bf\u30df\u30f3\u9178\u751f\u5408\u6210\u9175\u7d20\u306f\u6301\u3064\u304c\u30b0\u30eb\u30bf\u30df\u30f3\u751f\u5408\u6210\u9175\u7d20\u3092\u6b20\u3044\u3066\u3044\u308b\u3002\u305f\u3060\u3053\u306e\u8868\u3067\u6ce8\u610f\u3059\u3079\u304d\u3053\u3068\u306f\u3001\u7a2e\u306e\u6570\u304c\u305d\u306e\u307e\u307e\u81ea\u7136\u754c\u306e\u5b58\u5728\u6bd4\u3092\u793a\u3057\u3066\u3044\u308b\u306e\u3067\u306f\u306a\u3044\u3053\u3068\u3067\u3042\u308d\u3046\u3002\u4eba\u306e\u6ce8\u610f\u3092\u5f15\u3044\u305f\u83cc\u7fa4\u304c\u96c6\u4e2d\u7684\u306b\u7814\u7a76\u3055\u308c\u305f\u305f\u3081\u3001\u591a\u304f\u306e\u7a2e\u304c\u5b58\u5728\u3059\u308b\u3088\u3046\u306b\u898b\u3048\u308b\u5834\u5408\u304c\u3042\u308b\u304b\u3089\u3067\u3042\u308b\u3002\u4f8b\u3048\u3070\u3001Chloroflexi\u79d1\u306b\u304a\u3044\u3066Dehalococcoides\u5c5e\u304c\u512a\u5148\u7a2e\u3067\u3042\u308b\u3088\u3046\u306b\u898b\u3048\u308b\u3002\u3057\u304b\u3057\u3001\u3053\u306e\u30b0\u30eb\u30fc\u30d7\u306ftetrachloroethane\u3084trichloroethylene\u306e\u3088\u3046\u306a\u30cf\u30ed\u30b2\u30f3\u5316\u70ad\u5316\u6c34\u7d20\u306b\u5bfe\u3059\u308b\u5206\u89e3\u80fd\u3092\u6301\u3064\u3060\u3051\u3067\u306a\u304f\u3001\u3053\u308c\u3089\u3092\u6df7\u5408\u57f9\u990a\u3059\u308b\u3068polychlorinated biphenyls\uff08PCBs\uff09\u3092\u3082\u5206\u89e3\u3067\u304d\u308b\u304c\u6545\u306b\u3001\u751f\u7269\u4fee\u5fa9\u306e\u671f\u5f85\u3092\u8fbc\u3081\u305f\u7814\u7a76\u304c\u96c6\u4e2d\u7684\u306b\u884c\u308f\u308c\u305f\u3053\u3068\u304c\u539f\u56e0\u3060\u3068\u601d\u308f\u308c\u308b\u3002<\/p>\n\n\n\n<p>\u3000\u305d\u308c\u304c\u3069\u3046\u3057\u305f\u3068\u8a00\u308f\u308c\u305d\u3046\u3060\u304c\u3001\u3082\u3046\u5c11\u3057\u4ed8\u304d\u5408\u3063\u3066\u307b\u3057\u3044\u3002\u6b21\u306e\u8868\u306f\u3001\u3084\u306f\u308a\u7cfb\u7d71\u6a39\u306e\u6df1\u3044\u4f4d\u7f6e\u306b\u5206\u5c90\u70b9\u3092\u6301\u3064\u3002\u306e\u30b0\u30eb\u30fc\u30d7\u306b\u3064\u3044\u3066\u3001\u30b0\u30eb\u30bf\u30df\u30f3\u9178\u95a2\u9023\u9175\u7d20\u7fa4\u306e\u5b58\u5728\u3092\u629c\u304d\u51fa\u3057\u305f\u3082\u306e\u3067\u3042\u308b\u3002\u3053\u3053\u306b\u304a\u3044\u3066\u308210\u7a2e\u306e\u83cc\u304c\u30b0\u30eb\u30bf\u30df\u30f3\u9178\u751f\u5408\u6210\u9175\u7d20\u3092\u6301\u305f\u306a\u3044\u306b\u3082\u304b\u304b\u308f\u3089\u305a\u3001\u30b0\u30eb\u30bf\u30df\u30f3\u9178\u304b\u3089\u30b0\u30eb\u30bf\u30df\u30f3\u3092\u4f5c\u308b\u9175\u7d20\u3092\u6301\u3064\u3002<\/p>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"aligncenter\"><a href=\"http:\/\/bamboolab.ok-japan.com\/?attachment_id=3813\" rel=\"attachment wp-att-3813\"><img decoding=\"async\" src=\"http:\/\/bamboolab.ok-japan.com\/wp-content\/uploads\/2016\/12\/\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8-2016-12-22-20.59.48.png\" alt=\"\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8 2016-12-22 20.59.48\" class=\"wp-image-3813\"\/><\/a><figcaption>\uff08\u7dd1\u306b\u5857\u3063\u305f\u90e8\u5206\u306e\u9175\u7d20\u304c\u5b58\u5728\u3059\u308b\uff09<\/figcaption><\/figure><\/div>\n\n\n\n<p>\u3000\u4e8c\u3064\u306e\u8868\u306b\u793a\u3057\u305f\u83cc\u7fa4\u306f\u5c11\u6570\u306e\u597d\u6c17\u6027\u7d30\u83cc\u306f\u542b\u3080\u3082\u306e\u306e\u3001\u5927\u591a\u6570\u304c\u5acc\u6c17\u6027\u306e\u597d\u71b1\u7d30\u83cc\u3067\u3042\u308b\u3002\u305d\u3057\u3066\u5730\u7403\u4e0a\u306b\u6700\u521d\u306b\u73fe\u308c\u305f\u751f\u7269\u306b\u3068\u3066\u3082\u8fd1\u3044\u30b0\u30eb\u30fc\u30d7\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u308b\u3002\u3068\u306f\u3044\u3048\u3001Aquificae\u79d1\u306b\u3064\u3044\u3066\u306f\u3001\u6700\u3082\u53e4\u3044\u771f\u6b63\u7d30\u83cc\u3068\u898b\u306a\u3055\u308c\u3066\u3044\u308b\u3044\u308b\u3068\u306f\u3044\u3048\u3001\u30d7\u30ed\u30c6\u30aa\u30d0\u30af\u30c6\u30ea\u30a2\u304b\u3089\u6d3e\u751f\u3057\u305f\u7cfb\u7d71\u3067\u3042\u308b\u3068\u3059\u308b\u30c7\u30fc\u30bf\u3082\u306a\u3044\u308f\u3051\u3067\u306f\u306a\u3044\u3002\u8868\u306e\u6700\u5f8c\u306b\u8f09\u305b\u3066\u3044\u308b<em>Candidatus Korarchaeum cryptofilum<\/em>\u306f\u3001\u307e\u3060\u5358\u96e2\u306f\u3055\u308c\u3066\u3044\u306a\u3044\u306b\u3057\u3066\u3082\u30b2\u30ce\u30e0\u89e3\u6790\u304c\u7d42\u308f\u3063\u3066\u3044\u308b\u53e4\u7d30\u83cc\u3067\u3001\u4e00\u822c\u7684\u306b\u306f<em>Aquifex aeolicus<\/em>\u3068\u3068\u3082\u306b\u3001\u7cfb\u7d71\u6a39\u306e\u6700\u3082\u6df1\u3044\u4f4d\u7f6e\u306b\u3067\u5206\u5c90\u3057\u305f\u3068\u3055\u308c\u3066\u3044\u308b\u3002\u3053\u306e\u83cc\u306e\u30b0\u30eb\u30bf\u30df\u30f3\u95a2\u9023\u4ee3\u8b1d\u7cfb\u306f\u3001glutamate dehydrogenase\u3068\u3068\u3082\u306b2\u7a2e\u985e\u306eglutamate synthase\u3060\u3051\u3067\u306a\u304f\u30b0\u30eb\u30bf\u30df\u30f3\u751f\u5408\u6210\u7cfb\u3082\u6301\u3061\u3001\u3055\u307b\u3069\u9055\u548c\u611f\u306e\u3042\u308b\u3082\u306e\u3067\u306f\u306a\u3044\u3002\u305f\u3060\u3001\u3053\u306e\u83cc\u306e\u57f9\u990a\u306e\u7d4c\u7def\u3092\u898b\u308b\u3068\u5f93\u5c5e\u6804\u990a\u751f\u7269\u3067\u3042\u308b\u3088\u3046\u306b\u601d\u3048\u308b\u3002\u3053\u306e\u53e4\u7d30\u83cc\u3067\u7570\u5e38\u306b\u7279\u5fb4\u7684\u306a\u306e\u306f\u3001\u30b0\u30eb\u30bf\u30df\u30f3\u304b\u30895-Phospho-D-ribosylamine\u3092\u901a\u3063\u3066\u59cb\u307e\u308b\u30d7\u30ea\u30f3\u30cc\u30af\u30ec\u30aa\u30c1\u30c9\u4ee3\u8b1d\u7cfb\u306e\u521d\u767a\u9175\u7d20\u3067\u3042\u308bamidophosphoribosyltransferase\u3068Carbamoyl phosphate\u304b\u3089\u59cb\u307e\u308b\u30d4\u30ea\u30df\u30b8\u30f3\u30cc\u30af\u30ec\u30aa\u30c1\u30c9\u751f\u5408\u6210\u7cfb\u306e\u521d\u767a\u9175\u7d20\u3067\u3042\u308bcarbamoyl-phosphate synthase\u306e\u4e21\u65b9\u3092\u6b20\u3044\u3066\u3044\u308b\u3053\u3068\u3067\u3042\u308b\u3002\u6700\u3082Carbamoyl phosphate\u306b\u3064\u3044\u3066\u306fcarbamate kinase\u306e\u5b58\u5728\u4e0b\u306b\u30a2\u30f3\u30e2\u30cb\u30a2\u3068\u4e8c\u9178\u5316\u70ad\u7d20\u3068ATP\u304b\u3089\u751f\u5408\u6210\u3059\u308b\u7cfb\u304c\u5b58\u5728\u3059\u308b\u306e\u3067\u3001\u3053\u306e\u7cfb\u3092\u4ee3\u7528\u3057\u3066\u3044\u308b\u306e\u304b\u3082\u3057\u308c\u306a\u3044\u3002\u30d7\u30ea\u30f3\u30cc\u30af\u30ec\u30aa\u30c1\u30c9\u3068\u30d4\u30ea\u30df\u30b8\u30f3\u30cc\u30af\u30ec\u30aa\u30c1\u30c9\u306e\u751f\u5408\u6210\u7cfb\u3092\u898b\u3066\u307f\u308b\u3068\u3001\u524d\u8005\u304c\u4ee3\u8b1d\u9175\u7d20\u306b\u6b20\u640d\u306e\u591a\u3044\u30b9\u30ab\u30b9\u30ab\u306e\u7cfb\u3067\u3042\u308b\u306e\u306b\u6bd4\u3057\u3066\u3001\u5f8c\u8005\u306f\u304b\u306a\u308a\u5145\u5b9f\u3057\u305f\u7d4c\u8def\u3092\u69cb\u6210\u3057\u3066\u304a\u308a\u3001\u5148\u306e\u7d50\u679c\u3092\u53cd\u6620\u3057\u3066\u3044\u308b\u306e\u304b\u3082\u3057\u308c\u306a\u3044\u3002\u3053\u306e\u8fba\u308a\u306e\u9175\u7d20\u7fa4\u306b\u3064\u3044\u3066\u306f\u3001\u810a\u690e\u52d5\u7269\u306fglutamine synthase\u3092\u6301\u305f\u306a\u3044\u3001\u7bc0\u8db3\u52d5\u7269\u3084\u8edf\u4f53\u52d5\u7269\u306fglutamine synthase\u3068\u3068\u3082\u306bglutamine dehydrogenase\u4e21\u7cfb\u7d71\u306e\u9175\u7d20\u3092\u6301\u3064\u3001\u690d\u7269\u3082\u4e21\u7cfb\u7d71\u306e\u9175\u7d20\u3092\u6301\u3064\u306a\u3069\u3068\u8272\u3005\u3068\u8003\u3048\u3055\u305b\u308b\u5206\u5e03\u3092\u793a\u3057\u7d50\u69cb\u9762\u767d\u3044\u3002<\/p>\n\n\n\n<p>\u3000\u3053\u3053\u307e\u3067\u8aad\u307e\u308c\u3066\u3001\u3053\u3044\u3064\u306f\u4f55\u304c\u8a00\u3044\u305f\u3044\u306e\u3060\u308d\u3046\u3068\u3044\u3046\u7591\u554f\u304c\u8aad\u8005\u306e\u4e2d\u306b\u6e67\u3044\u3066\u304d\u305f\u306e\u3067\u306f\u306a\u3044\u304b\u3068\u601d\u3046\u3002\u307e\u3068\u3081\u3066\u307f\u3088\u3046\u3002\u8a00\u3044\u305f\u3044\u3053\u3068\u306f\u4e8c\u3064\u3042\u308b\u3002\u4e00\u3064\u306f\u4e00\u898b\u751f\u547d\u7dad\u6301\u306b\u4e0d\u53ef\u6b20\u306a\u4ee3\u8b1d\u7cfb\u306b\u6b20\u640d\u90e8\u5206\u304c\u3042\u3063\u305f\u3068\u3057\u3066\u3082\uff08\u3053\u306e\u90e8\u5206\u306e\u4ee3\u8b1d\u9175\u7d20\u304c\u306a\u3044\u3068\u3044\u3046\u610f\u5473\uff09\u3001\u751f\u7269\u306f\u3053\u308c\u3092\u82e6\u306b\u3059\u308b\u3053\u3068\u306a\u304f\u751f\u304d\u5ef6\u3073\u3066\u3044\u308b\u3068\u3044\u3046\u4e8b\u5b9f\u3067\u3042\u308b\u3002\u3064\u307e\u308a\u3001\u540c\u3058\u53cd\u5fdc\u7279\u7570\u6027\u3092\u6301\u3064\u5225\u306e\u9175\u7d20\u304c\u3053\u306e\u90e8\u5206\u3092\u88dc\u3063\u3066\u3044\u308b\u306e\u3067\u3042\u308d\u3046\u3002\u4f55\u5ea6\u3082\u3044\u3046\u3088\u3046\u3060\u304c\u3001\u9175\u7d20\u306e\u57fa\u8cea\u7279\u7570\u6027\u306f\u6211\u3005\u304c\u601d\u3046\u307b\u3069\u9ad8\u304f\u306f\u306a\u3044\u3002\u3057\u3064\u3053\u3044\u3068\u601d\u308f\u308c\u308b\u304b\u3082\u3057\u308c\u306a\u3044\u304c\u3001\u6559\u80b2\u306e\u4e2d\u3067\u9175\u7d20\u306e\u53b3\u5bc6\u306a\u57fa\u8cea\u7279\u7570\u6027\u3068\u3044\u3046\u6982\u5ff5\u3092\u5237\u308a\u8fbc\u307e\u308c\u3001\u4e14\u3064\u79c1\u81ea\u8eab\u304c\u53b3\u5bc6\u306a\u57fa\u8cea\u7279\u7570\u6027\u306f\u8aa4\u308a\u3067\u3042\u308b\u3068\u601d\u3044\u306a\u304c\u3089\u3082\u610f\u306b\u53cd\u3057\u305f\u8b1b\u7fa9\u3092\u884c\u3063\u3066\u304d\u305f\u4eba\u9593\u3068\u3057\u3066\u3001\u3053\u308c\u306f\u58f0\u3092\u5927\u306b\u3057\u3066\u8a00\u3063\u3066\u304a\u304d\u305f\u3044\u3002<\/p>\n\n\n\n<p>\u3000\u3044\u307e\u4e00\u3064\u306f2-oxoglutaric acid\u3092\u542b\u3080TCA\u56de\u8def\u306e\u610f\u7fa9\u306b\u3064\u3044\u3066\u306e\u89e3\u91c8\u3067\u3042\u308b\u3002\u3053\u306e\u5834\u5408\u3082\u3001TCA\u56de\u8def\u3092\u89e3\u7cd6\u7cfb\u306b\u7d9a\u304f\u7cd6\u306e\u597d\u6c17\u7684\u5206\u89e3\u7d4c\u8def\u3067\u3042\u308aATP\u751f\u7523\u306e\u305f\u3081\u306e\u7d4c\u8def\u3067\u3042\u308b\u3068\u3059\u308b\u5e38\u8b58\u304c\u30d2\u30c8\u3092\u542b\u3080\u4e00\u90e8\u306e\u751f\u7269\u306b\u304a\u3044\u3066\u6210\u7acb\u3059\u308b\u306b\u3059\u304e\u306a\u3044\u3068\u3044\u3046\u4e8b\u5b9f\u3067\u3042\u308b\u3002\u30d6\u30ed\u30b0\u306e\u3053\u306e\u90e8\u5206\u3060\u3051\u3092\u8aad\u307e\u308c\u305f\u65b9\u3005\u306f\u3001\u5510\u7a81\u306b\u306a\u3093\u3068\u3044\u3046\u975e\u5e38\u8b58\u306a\u3053\u3068\u3092\u66f8\u304f\u306e\u304b\u3068\u7709\u306b\u553e\u3092\u3064\u3051\u3089\u308c\u308b\u304b\u3082\u3057\u308c\u306a\u3044\u3002\u3057\u304b\u3057\u3001\u6b8b\u5ff5\u306a\u304c\u3089\u5e38\u8b58\u7684\u89e3\u91c8\u306f\u9593\u9055\u3063\u3066\u3044\u308b\u3002\u8a73\u3057\u3044\u7406\u7531\u306b\u3064\u3044\u3066\u306f\u62d9\u30d6\u30ed\u30b0\u306eTCA\u56de\u8def\u3078\u306e\u7570\u8ad6\u306b\u66f8\u3044\u3066\u3044\u308b\u304c\u3001\u3053\u3053\u3067\u3082\u5c11\u3057\u3060\u3051\u305d\u306e\u6839\u62e0\u3068\u306a\u308b\u4f8b\u3092\u793a\u3057\u3066\u304a\u304f\u3002\u4e0b\u56f3\u3092\u898b\u3066\u307b\u3057\u3044\u3002<\/p>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"aligncenter\"><a href=\"http:\/\/bamboolab.ok-japan.com\/?attachment_id=3816\"><img decoding=\"async\" src=\"http:\/\/bamboolab.ok-japan.com\/wp-content\/uploads\/2016\/12\/\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8-2016-12-22-17.31.06.png\" alt=\"\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8 2016-12-22 17.31.06\" class=\"wp-image-3816\"\/><\/a><\/figure><\/div>\n\n\n\n<p>\u3000\u3053\u306e\u56f3\u306f\u4eca\u8b70\u8ad6\u3057\u3066\u3044\u308b\u7d30\u83cc\u306e\u30b0\u30eb\u30fc\u30d7\u306e\u4e2d\u3067\u3001Euryarchaeota&nbsp;\u306b\u5c5e\u3059\u308b\u53e4\u7d30\u83cc<em>Methanococcus maripaludis<\/em>&nbsp;S2 \u306eTCA\u56de\u8def\u3092\u793a\u3057\u3066\u3044\u308b\u3002\u3053\u306e\u56f3\u306b\u304a\u3044\u3066\u3001\u7dd1\u306b\u5857\u3089\u308c\u305f\u67a0\u5185\u306e\u9175\u7d20\u304c\u5b58\u5728\u3059\u308b\u9175\u7d20\u3067\u3042\u308b\u3002\u3053\u306e\u53e4\u7d30\u83cc\u306e\u56de\u8def\u306b\u306a\u3063\u3066\u3044\u306a\u3044TCA\u56de\u8def\u306f\u3001\u901a\u5e38\u306eTCA\u56de\u8def\u3068\u53cd\u5bfe\u65b9\u5411\u306e\u30d9\u30af\u30c8\u30eb\u3092\u6301\u3063\u3066\u3044\u308b\u3088\u3046\u3060\u3002\u30d5\u30de\u30eb\u9178\u3068\u30b3\u30cf\u30af\u9178\u306e\u9593\u304c\u5207\u308c\u3066\u3044\u308b\u3088\u3046\u306b\u898b\u3048\u308b\u304c\u3001\u3053\u306e\u53cd\u5fdc\u306f\u4e8c\u91cd\u7d50\u5408\u306b\u5bfe\u3059\u308b\u6c34\u7d20\u6dfb\u52a0\u53cd\u5fdc\u3067\u3042\u308b\u305f\u3081\u3001\u8102\u8cea\u4ee3\u8b1d\u3067\u50cd\u304freductase\u306e\u3088\u3046\u306a\u57fa\u8cea\u7279\u7570\u6027\u306e\u4f4e\u3044\u9175\u7d20\u304c\u4ee3\u308f\u308a\u306b\u50cd\u3044\u3066\u3044\u308b\u306e\u3067\u3042\u308d\u3046\u3002\u30aa\u30ae\u30b6\u30ed\u9162\u9178\u304b\u30892-\u30aa\u30af\u30bd\u30b0\u30eb\u30bf\u30eb\u9178\u307e\u3067\u306e\u9593\u3067\u30012\u5206\u5b50\u306eNADPH2\u30681\u5206\u5b50\u306eATP\u305d\u3057\u30661\u5206\u5b50\u306e\u9084\u5143\u578b\u30d5\u30a7\u30ec\u30c9\u30ad\u30b7\u30f3\u3092\u6d88\u8cbb\u3057\u3066\u3044\u308b\u3002\u3053\u306e\u56de\u8def\u306b\u306a\u3063\u3066\u3044\u306a\u3044\u3001\u9006\u5411\u304d\u306e\u30d9\u30af\u30c8\u30eb\u3092\u6301\u3061\u30a8\u30cd\u30eb\u30ae\u30fc\u3092\u6d88\u8cbb\u3059\u308b\u7cfb\u3092TCA\u56de\u8def\u3068\u3057\u3066\u5206\u985e\u3059\u308b\u6839\u62e0\u306f\u4f55\u51e6\u306b\u3042\u308b\u306e\u3060\u308d\u3046\u304b\u3002<em>Methanococcus maripaludis\u306b\u304a\u3044\u3066\u3001<\/em>\u3082\u3057\u3001\u4e07\u4e00\u3053\u306e\u7cfb\u304c\u9006\u5411\u304d\u306b\u52d5\u3044\u305f\u3068\u3057\u3066\u3082\u3001\u56f0\u3063\u305f\u3053\u3068\u306b\u3053\u306e\u83cc\u306fNADPH2\u304b\u3089ATP\u751f\u7523\u3092\u884c\u3046\u9178\u5316\u7684\u30ea\u30f3\u9178\u5316\u3092\u884c\u3046\u3053\u3068\u306f\u3067\u304d\u306a\u3044\u305f\u306e\u3067\u3042\u308b\u3002<\/p>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"aligncenter\"><a href=\"http:\/\/bamboolab.ok-japan.com\/?attachment_id=3815\" rel=\"attachment wp-att-3815\"><img decoding=\"async\" src=\"http:\/\/bamboolab.ok-japan.com\/wp-content\/uploads\/2016\/12\/\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8-2016-12-22-18.43.50.png\" alt=\"\" class=\"wp-image-3815\"\/><\/a><figcaption><em>Methanococcus maripaludis S2<\/em>\u306e\u9178\u5316\u7684\u30ea\u30f3\u9178\u5316\u3092\u5b9f\u884c\u3067\u304d\u306a\u3044\u9178\u5316\u7684\u30ea\u30f3\u9178\u5316\u7d4c\u8def &nbsp;\u3000\u3000\u3000\u3000\u3000\u3000\uff08\u7dd1\u306e\u67a0\u5185\u306b\u66f8\u3044\u3066\u3042\u308b\u9175\u7d203.6.1.1\u30683.6.3.14\u306e\u307f\u304c\u5b58\u5728\u3059\u308b\uff09<\/figcaption><\/figure><\/div>\n\n\n\n<p>\u3000\u4e0a\u306e\u56f3\u306b\u793a\u3059\u3088\u3046\u306b\u3001\u3053\u306e\u53e4\u7d30\u83cc\u306fATP\u3092\u751f\u7523\u3059\u308b\u9178\u5316\u7684\u30ea\u30f3\u9178\u5316\u7d4c\u8def\u3092\u69cb\u6210\u3059\u308b\u8981\u7d20\u306e\u307b\u307c\u3059\u3079\u3066\u3092\u6b20\u5931\u3057\u3066\u3044\u308b\u3002TCA\u56de\u8def\u306b\u5bfe\u3059\u308b\u77db\u76fe\u306b\u6e80\u3061\u305f\u8aac\u660e\u306f\u3001\u4f55\u51e6\u304b\u3067\u6b63\u3059\u5fc5\u8981\u304c\u3042\u308b\u306e\u3067\u306f\u306a\u3044\u304b\u3002<\/p>\n\n\n\n<p>\u3000\u6838\u9178\u306e\u751f\u5408\u6210\u3092\u8a9e\u308b\u3064\u3082\u308a\u304c\u3001\u5165\u308a\u53e3\u3067\u624b\u9593\u53d6\u3063\u3066\u3057\u307e\u3063\u305f\u3002\u6b21\u56de\u306f\u30b9\u30e0\u30fc\u30b9\u306b\u9032\u3081\u308b\u4e88\u5b9a\u3067\u3042\u308b\u3002<\/p>\n\n\n\n<p>\u3000\u6700\u5f8c\u306b\u3001\u6bce\u56de\u540c\u3058\u3053\u3068\u3092\u8a00\u3046\u3088\u3046\u3060\u304cKEGG\u3092\u4f5c\u6210\u30fb\u904b\u55b6\u3057\u3066\u3044\u308b\u65b9\u3005\u306b\u611f\u8b1d\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u904e\u5270\u3068\u8569\u5c3d\u300029\u3000\u306b\u7d9a\u304f<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u3000\u3059\u3079\u3066\u306e\u751f\u4f53\u7269\u8cea\u3092\u9178\u7d20\u3068\u7d61\u3081\u3066\u898b\u76f4\u3059\u3079\u304d\u3060\u3068\u3059\u308b\u79c1\u306e\u8003\u3048\u65b9\u3092\u63a1\u7528\u3059\u308b\u306a\u3089\u3070\u3001\u9762 &hellip; <a href=\"https:\/\/bamboolab.yamasatoagr.com\/?p=5615\">\u7d9a\u304d\u3092\u8aad\u3080 <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-5615","post","type-post","status-publish","format-standard","hentry","category-1"],"_links":{"self":[{"href":"https:\/\/bamboolab.yamasatoagr.com\/index.php?rest_route=\/wp\/v2\/posts\/5615","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/bamboolab.yamasatoagr.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/bamboolab.yamasatoagr.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/bamboolab.yamasatoagr.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/bamboolab.yamasatoagr.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=5615"}],"version-history":[{"count":1,"href":"https:\/\/bamboolab.yamasatoagr.com\/index.php?rest_route=\/wp\/v2\/posts\/5615\/revisions"}],"predecessor-version":[{"id":5616,"href":"https:\/\/bamboolab.yamasatoagr.com\/index.php?rest_route=\/wp\/v2\/posts\/5615\/revisions\/5616"}],"wp:attachment":[{"href":"https:\/\/bamboolab.yamasatoagr.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=5615"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/bamboolab.yamasatoagr.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=5615"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/bamboolab.yamasatoagr.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=5615"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}