{"id":5613,"date":"2016-11-12T13:07:05","date_gmt":"2016-11-12T04:07:05","guid":{"rendered":"http:\/\/bamlab.ok-japan.com\/?p=5613"},"modified":"2019-11-02T13:07:23","modified_gmt":"2019-11-02T04:07:23","slug":"%e9%81%8e%e5%89%b0%e3%81%a8%e8%95%a9%e5%b0%bd%e3%80%8027","status":"publish","type":"post","link":"https:\/\/bamboolab.yamasatoagr.com\/?p=5613","title":{"rendered":"\u904e\u5270\u3068\u8569\u5c3d\u300027"},"content":{"rendered":"\n

\u3000\u306a\u3093\u3068\u306a\u304f\u66d6\u6627\u306a\u5f62\u3067\u30ad\u30b5\u30f3\u30c8\u30d5\u30a3\u30eb\u30b5\u30a4\u30af\u30eb\u3092\u7d42\u308f\u3063\u3066\u3057\u307e\u3063\u305f\u3002\u601d\u3044\u3064\u304f\u307e\u307e\u306b\u66f8\u3044\u3066\u3044\u308b\u305f\u3081\u3001\u3069\u3046\u3082\u5168\u4f53\u306e\u7e8f\u307e\u308a\u306b\u6b20\u3051\u308b\u3088\u3046\u306b\u611f\u3058\u308b\u304c\u3001\u3042\u308c\u4ee5\u4e0a\u306e\u8b70\u8ad6\u3092\u3059\u308b\u3068\u3082\u3063\u3068\u932f\u7d9c\u3057\u305d\u3046\u3067\u3042\u308b\u3002\u73fe\u5728\u884c\u308f\u308c\u3066\u3044\u308b\u8aac\u660e\u306b\u3061\u3087\u3063\u3068\u3070\u304b\u308a\u77f3\u3092\u6295\u3052\u6ce2\u7d0b\u306e\u5e83\u304c\u308b\u306e\u3092\u697d\u3057\u307f\u306b\u3059\u308b\u3068\u540c\u6642\u306b\u3001\u79c1\u306e\u7acb\u3061\u4f4d\u7f6e\u304b\u3089\u306e\u4e00\u3064\u306e\u4eee\u8aac\u3092\u63d0\u793a\u3057\u305f\u3082\u306e\u3068\u3057\u3066\u53d7\u3051\u53d6\u3063\u3066\u307b\u3057\u3044\u3002<\/p>\n\n\n\n

\u3000\u305d\u308c\u306f\u305d\u3046\u3068\u3057\u3066\u3001\u3053\u3053\u3067\u66f8\u3044\u3066\u304a\u304b\u306d\u3070\u66f8\u304f\u6a5f\u4f1a\u3092\u306a\u304f\u3057\u3066\u3057\u307e\u3044\u305d\u3046\u306a\u8a71\u984c\u304c\u307e\u3060\u3072\u3068\u3064\u6b8b\u3063\u3066\u3044\u308b\u3002\u305d\u308c\u306f\u30dd\u30eb\u30d5\u30a3\u30ea\u30f3\u306b\u3064\u3044\u3066\u306e\u3082\u306e\u3067\u3042\u308b\u3002\u30dd\u30eb\u30d5\u30a3\u30ea\u30f3\u306f\u524d\u3005\u56de\u307e\u3067\u3067\u7d42\u308f\u3063\u305f\u306e\u3067\u306f\u306a\u3044\u304b\u3068\u601d\u308f\u308c\u308b\u304b\u3082\u3057\u308c\u306a\u3044\u304c\u3001\u9178\u7d20\u5206\u5b50\u3068\u30dd\u30eb\u30d5\u30a3\u30ea\u30f3\u3092\u7d61\u307e\u3057\u305f\u5f62\u3067\u306e\u8b70\u8ad6\u306f\u624b\u3064\u304b\u305a\u3067\u6b8b\u3063\u3066\u3044\u308b\u3002\u30ad\u30b5\u30f3\u30c8\u30d5\u30a3\u30eb\u30b5\u30a4\u30af\u30eb\u306e\u8b70\u8ad6\u306e\u6700\u7d42\u90e8\u5206\u3067\u8ff0\u3079\u305f\u300cOxygenative Burst Hypothesis\u300d\u306b\u3001\u30dd\u30eb\u30d5\u30a3\u30eb\u30f3\u304c\u9069\u5408\u3057\u3066\u3044\u308b\u304b\u3069\u3046\u304b\u306e\u691c\u8a3c\u306f\u3001\u4eca\u3053\u3053\u3067\u884c\u3046\u306e\u304c\u9069\u5207\u3067\u3042\u308d\u3046\u3068\u3044\u3046\u5224\u65ad\u3067\u3042\u308b\u3002<\/p>\n\n\n\n

\u3000\u30dd\u30eb\u30d5\u30a3\u30ea\u30f3\u3068\u9178\u7d20\u306e\u95a2\u9023\u306f\u3001\u601d\u3063\u305f\u4ee5\u4e0a\u306b\u8907\u96d1\u3067\u3042\u308b\u3002\u3055\u3089\u306b\u3001\u9178\u5316\u7684\u751f\u7269\u3068\u3057\u3066\u306e\u4eba\u306e\u751f\u304d\u69d8\u304c\u3001\u3053\u306e\u95a2\u84ee\u3092\u8a9e\u308b\u6642\u306b\u5927\u304d\u306a\u8aa4\u89e3\u306e\u30d1\u30e9\u30c0\u30a4\u30e0\u3092\u5f62\u6210\u3057\u3066\u3044\u308b\u3088\u3046\u3060\u3002\u3053\u306e\u3001\u8aa4\u8b2c\u306e\u4f53\u7cfb\u3092\u6253\u7834\u3057\u305f\u4e0a\u3067\u65b0\u305f\u306a\u8a8d\u8b58\u4f53\u7cfb\u3092\u69cb\u7bc9\u3059\u308b\u306e\u306f\u3001\u4e00\u4eba\u3067\u3067\u304d\u308b\u307b\u3069\u7c21\u5358\u306a\u3053\u3068\u3067\u306f\u306a\u3044\u3068\u7406\u89e3\u3057\u305f\u4e0a\u3067\u3001\u306a\u3093\u3068\u304b\u63fa\u3059\u3076\u308b\u52aa\u529b\u3092\u3057\u3066\u307f\u3088\u3046\u3002<\/p>\n\n\n\n

\u3000\u30dd\u30eb\u30d5\u30a3\u30ea\u30f3\u74b0\u3092\u6301\u3064\u7269\u8cea\u7fa4\u3092\u3001\u7d30\u304b\u306a\u5206\u985e\u306f\u6a2a\u306b\u7f6e\u3044\u3066\u30e9\u30f3\u30c0\u30e0\u306b\u7f85\u5217\u3057\u3066\u307f\u308b\u3002\u307e\u305a\u3001\u30af\u30ed\u30ed\u30d5\u30a3\u30eb\u3001\u30d7\u30ed\u30c8\u30dd\u30eb\u30d5\u30a3\u30ea\u30f3\u3001\u30d8\u30e2\u30b0\u30ed\u30d3\u30f3\u3001\u30df\u30aa\u30b0\u30ed\u30d3\u30f3\u3001\u30da\u30eb\u30aa\u30ad\u30b7\u30c0\u30fc\u30bc\u3001\u30b7\u30c8\u30af\u30ed\u30e0\u3001\u30ab\u30bf\u30e9\u30fc\u30bc\u3001\u30b7\u30a2\u30ce\u30b3\u30d0\u30e9\u30df\u30f3\u306a\u3069\u3092\u3059\u3050\u306b\u601d\u3044\u3064\u304f\u3060\u308d\u3046\u3002\u30d7\u30ed\u30c8\u30dd\u30eb\u30d5\u30a3\u30ea\u30f3\u3092\u3069\u3046\u6271\u3046\u304b\u304c\u554f\u984c\u306b\u306a\u308b\u3068\u601d\u3046\u304c\u3001\u3044\u308f\u3086\u308b\u5149\u5408\u6210\u306b\u95a2\u4e0e\u3059\u308b\u30af\u30ed\u30ed\u30d5\u30a3\u30eb\u3001\u9178\u7d20\u306b\u76f4\u63a5\u95a2\u4e0e\u3059\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u30d8\u30e2\u30b0\u30ed\u30d3\u30f3\u3001\u30df\u30aa\u30b0\u30ed\u30d3\u30f3\u3001\u30da\u30eb\u30aa\u30ad\u30b7\u30c0\u30fc\u30bc\u3001\u30b7\u30c8\u30af\u30ed\u30e0\u3001\u30ab\u30bf\u30e9\u30fc\u30bc\u3001\u305d\u3057\u3066DNA\u306e\u751f\u5408\u6210\u3084\u30d3\u30bf\u30df\u30f3\u3067\u3042\u308b\u8449\u9178\u306e\u518d\u751f\u3001\u8449\u9178\u306e\u518d\u751f\u3092\u901a\u3057\u305f\u5947\u6570\u9396\u8102\u80aa\u9178\u306e\u4ee3\u8b1d\u306a\u3069\u306b\u95a2\u4e0e\u3059\u308b\u30b7\u30a2\u30ce\u30b3\u30d0\u30e9\u30df\u30f3\u985e\u3068\u5206\u985e\u3059\u308b\u306e\u304c\u59a5\u5f53\u3067\u3042\u308d\u3046\u3002\u5f93\u3063\u3066\u3001\u3053\u306e\u5206\u985e\u3092\u57fa\u790e\u3068\u3057\u3066\u5e7e\u3064\u304b\u306e\u8b70\u8ad6\u3092\u3059\u308b\u3053\u3068\u306b\u3059\u308b\u3002\u4ee5\u4e0b\u306bKEGG\u306ePorphyrin and chlorophyll metabolism – Reference pathway\u306e\u30de\u30c3\u30d7\u3092\u793a\u3059\u304c\u3001\u3053\u306e\u307e\u307e\u3067\u306f\u5c0f\u3055\u3059\u304e\u308b\u3068\u601d\u3046\u306e\u3067\u672c\u6765\u306e\u30b5\u30a4\u30c8\u304b\u3089\u5927\u304d\u3081\u306b\u30d7\u30ea\u30f3\u30c8\u30a2\u30a6\u30c8\u3057\u3066\u8b70\u8ad6\u3092\u30d5\u30a9\u30ed\u30fc\u3057\u3066\u307b\u3057\u3044\u3002<\/p>\n\n\n\n

\"\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8<\/a>
Porphyrin and chlorophyll metabolism – Reference pathway<\/figcaption><\/figure><\/div>\n\n\n\n

\u3000\u307e\u305a\u521d\u3081\u306e\u554f\u984c\u3060\u304c\u30dd\u30eb\u30d5\u30a3\u30ea\u30f3\u74b0\u3092\u542b\u3080\u5316\u5408\u7269\u7fa4\u306b\u304a\u3044\u3066\u3001\u3069\u306e\u6bb5\u968e\u3067\u30aa\u30ad\u30b7\u30b2\u30ca\u30fc\u30bc\u304c\u95a2\u4e0e\u3059\u308b\u9178\u5316\u53cd\u5fdc\u304c\u51fa\u73fe\u3059\u308b\u306e\u304b\u3002\u30dd\u30eb\u30d5\u30a3\u30ea\u30f3\u74b0\u3092\u6301\u3064\u30af\u30ed\u30ed\u30d5\u30a3\u30eb\u304c\u9178\u7d20\u767a\u751f\u578b\u5149\u5408\u6210\u3092\u884c\u3046\u3088\u3046\u306b\u306a\u3063\u305f\u3002\u3057\u304b\u3057\u3001\u30af\u30ed\u30ed\u30d5\u30a3\u30eb\u306e\u751f\u5408\u6210\u306b\u306f\u5206\u5b50\u72b6\u9178\u7d20\u304c\u5fc5\u8981\u3067\u3042\u308b\u3068\u3044\u3046\u306e\u3067\u306f\u3001\u6642\u7cfb\u5217\u7684\u306a\u8a71\u304c\u304a\u304b\u3057\u304f\u306a\u3063\u3066\u3057\u307e\u3046\u3002<\/p>\n\n\n\n

\u3000\u3064\u304e\u306b\u3001\u3053\u306e\u30dd\u30eb\u30d5\u30a3\u30ea\u30f3\u74b0\u3092\u6301\u30643\u3064\u306e\u5316\u5408\u7269\u7fa4\u3092\u5730\u7403\u5316\u5b66\u7684\u6b74\u53f2\u89b3\u306e\u4e0b\u3067\u53e4\u3044\u9806\u306b\u4e26\u3079\u308b\u3068\u3059\u308c\u3070\u3069\u3046\u306a\u308b\u306e\u3060\u308d\u3046\u3002\u3069\u306e\u5316\u5408\u7269\u7fa4\u304c\u53e4\u304f\u3001\u3069\u306e\u5316\u5408\u7269\u7fa4\u304c\u65b0\u3057\u3044\u306e\u304b\u30023\u3064\u306e\u5316\u5408\u7269\u7fa4\u306e\u9593\u306b\u6642\u9593\u7684\u95a2\u4fc2\u3092\u6301\u3061\u8fbc\u3081\u308c\u3070\u3001\u751f\u5408\u6210\u7cfb\u306e\u751f\u7269\u306b\u304a\u3051\u308b\u9032\u5316\u306e\u9053\u7b4b\u306b\u65b0\u305f\u306a\u8996\u70b9\u306e\u5c0e\u5165\u304c\u53ef\u80fd\u3068\u306a\u308b\u304b\u3082\u3057\u308c\u306a\u3044\u3002<\/p>\n\n\n\n

\u3000\u3044\u307e\u4e00\u3064\u3001\u6614\u304b\u3089\u7591\u554f\u306b\u601d\u3063\u3066\u3044\u305f\u3053\u3068\u3060\u304c\u3001\u30d8\u30e2\u30b0\u30ed\u30d3\u30f3\u3092\u5358\u306b\u30d8\u30e2\u30b0\u30ed\u30d3\u30f3\u5358\u72ec\u3067\u898b\u308b\u306e\u3067\u306f\u306a\u304f\u305d\u306e\u4ed6\u306e\u9178\u7d20\u7d50\u5408\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u4e00\u54e1\u3068\u3057\u3066\u898b\u305f\u3068\u304d\u3001\u3069\u306e\u3088\u3046\u306b\u898b\u3048\u308b\u304b\u3068\u3044\u3046\u554f\u3044\u304b\u3051\u3067\u3042\u308b\u3002\u5df7\u9593\u306b\u6d41\u5e03\u3057\u3066\u3044\u308b\u30d8\u30e2\u30b0\u30ed\u30d3\u30f3\u3092\u9178\u7d20\u904b\u642c\u30bf\u30f3\u30d1\u30af\u8cea\u3068\u3057\u3066\u6349\u3048\u308b\u8003\u3048\u65b9\u3067\u306f\u3001\u30ec\u30b0\u30d8\u30e2\u30b0\u30ed\u30d3\u30f3\u306f\u8aac\u660e\u304c\u96e3\u3057\u3044\u3002\u52ff\u8ad6\u3001\u3053\u306e\u5206\u91ce\u306e\u7814\u7a76\u8005\u304c\u3001\u305d\u308c\u306a\u308a\u306e\u7b54\u3048\u3092\u51fa\u3057\u3066\u3044\u308b\u3053\u3068\u306f\u627f\u77e5\u3057\u3066\u3044\u308b\u304c\u3001\u547c\u5438\u3092\u3057\u3066\u30a8\u30cd\u30eb\u30ae\u30fc\u3092\u5f97\u3066\u3044\u308b\u9178\u5316\u7684\u751f\u7269\u3068\u3057\u3066\u306e\u4eba\u306e\u751f\u304d\u69d8\u304c\u3001\u30d8\u30e2\u30b0\u30ed\u30d3\u30f3\u3092\u9178\u7d20\u904b\u642c\u30bf\u30f3\u30d1\u30af\u8cea\u3068\u3057\u3066\u6349\u3048\u308b\u5e38\u8b58\u3092\u5f62\u6210\u3059\u308b\u57fa\u76e4\u306b\u306a\u3063\u3066\u3044\u308b\u3068\u3044\u3046\u8996\u5ea7\u69cb\u9020\u306b\u3064\u3044\u3066\u89e6\u308c\u305f\u3044\u3068\u601d\u3046\u3002<\/p>\n\n\n\n

\u3000\u3068\u3044\u3046\u3053\u3068\u3067\u3001\u307e\u305a5-\u30a2\u30df\u30ce\u30ec\u30d6\u30ea\u30f3\u9178\u304b\u3089\u30af\u30ed\u30ed\u30d5\u30a3\u30eba\u307e\u3067\u306e\u7d4c\u8def\u3092\u898b\u308b\u3053\u3068\u306b\u3059\u308b\u3002\u5148\u306b\u793a\u3057\u305f\u30dd\u30eb\u30d5\u30a3\u30ea\u30f3\u751f\u5408\u6210\u306e\u56f3\u306b\u3001\u5404\u6bb5\u968e\u3067\u50cd\u304f\u9175\u7d20\u3092\u8ffd\u52a0\u3057\u3066\u518d\u5ea6\u793a\u3059\u3053\u3068\u306b\u3059\u308b\u3002<\/p>\n\n\n\n

\"\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8<\/a>
5-\u30a2\u30df\u30ce\u30ec\u30d6\u30ea\u30f3\u9178\u304b\u3089\u30af\u30ed\u30ed\u30d5\u30a3\u30eba\u307e\u3067\u306e\u7d4c\u8def<\/figcaption><\/figure><\/div>\n\n\n\n

\u3000\u6700\u521d\u306e\u56f3\u306f5-\u30a2\u30df\u30ce\u30ec\u30d6\u30ea\u30f3\u9178\u304b\u3089\u30d7\u30ed\u30c8\u30dd\u30eb\u30d5\u30a3\u30ea\u30f3IX\u307e\u3067\u306e\u5404\u6bb5\u968e\u3067\u50cd\u304f\u9175\u7d20\u3092\u793a\u3057\u3066\u3044\u308b\u3002\u3053\u306e\u56f3\u306b\u304a\u3044\u3066\u306fCoproporphyrinogen III\u304b\u3089Protoporphyrinogen IX\u3078\u306e\u5909\u63db\u306b\u304a\u3044\u3066\u50cd\u304fEC3.3.3\uff08coproporphyrinogen III oxidase\uff09\u3068Protoporphyrinogen IX\u304b\u3089Protoporphyrin IX\u3067\u50cd\u304fEC1.3.3.4\uff08protoporphyrinogen IX oxidase\uff09\u304c\u9178\u7d20\u5206\u5b50\u3092\u5229\u7528\u3059\u308b\u9175\u7d20\u3067\u3042\u308b\u304c\u3001\u524d\u6bb5\u306e\u53cd\u5fdc\u306b\u306foxygen-independent coproporphyrinogen III oxidase [EC:1.3.98.3]\u3001\u5f8c\u6bb5\u306e\u53cd\u5fdc\u306b\u306fmenaquinone-dependent protoporphyrinogen oxidase [EC:1.3.5.3]\u3068\u3044\u3046\u9178\u7d20\u3092\u5fc5\u8981\u3068\u3057\u306a\u3044\u9175\u7d20\u304c\u540c\u3058\u53cd\u5fdc\u3092\u89e6\u5a92\u3059\u308b\u3002\u3064\u307e\u308a\u3001\u9178\u7d20\u306e\u95a2\u4e0e\u306a\u3057\u306b\u30d7\u30ed\u30c8\u30dd\u30eb\u30d5\u30a3\u30ea\u30f3IX\u307e\u3067\u9032\u3081\u308b\u7cfb\u5b58\u5728\u3059\u308b\u3002<\/p>\n\n\n\n

\"\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8<\/a>
Protoporphyrin IX\u304b\u3089Chlorophyll a\u307e\u3067\u306e\u7d4c\u8def<\/figcaption><\/figure><\/div>\n\n\n\n

\u3000\u540c\u3058\u304f\u3001Protoporphyrin IX\u304b\u3089Chlorophyll a\u307e\u3067\u306e\u7cfb\u306b\u304a\u3044\u3066\u3082\u3001Mg-Protoporphyrin IX 13-monomethyl ester\u30682,4-Divinylprotochlorophyllide\u3092\u3064\u306a\u30503\u6bb5\u968e\u306e\u3092\u89e6\u5a92\u3059\u308bMg-protoporphyrin IX monomethyl ester (oxidative) cyclase\uff08EC14.13.81\uff09\u306f\u9178\u7d20\u5206\u5b50\u3092\u57fa\u8cea\u3068\u3059\u308b\u30aa\u30ad\u30b7\u30b2\u30ca\u30fc\u30bc\u3067\u3042\u308b\u304c\u3001\u3053\u3053\u306b\u65bc\u3044\u3066\u3082\u9178\u7d20\u3092\u4f7f\u308f\u306a\u3044bchE\uff08anaerobic magnesium-protoporphyrin IX monomethyl ester cyclase [EC:4.-.-.-]\uff09\u304c\u540c\u3058\u53cd\u5fdc\u3092\u89e6\u5a92\u3057\u30012,4-Divinylprotochlorophyllide\u307e\u3067\u306e\u5909\u63db\u304c\u53ef\u80fd\u3068\u306a\u3063\u3066\u3044\u308b\u3002\u86c7\u8db3\u304b\u3082\u3057\u308c\u306a\u3044\u304cChlorophyll b\u307e\u3067\u306e\u7d4c\u8def\u306b\u306fchlorophyllide a oxygenase [EC:1.14.13.122]\u3067\u89e6\u5a92\u3055\u308c\u308b\u9178\u7d20\u3092\u5fc5\u8981\u3068\u3059\u308b\u9178\u5316\u6bb5\u968e\u304c\u5b58\u5728\u3057\u3001\u3053\u306e\u7cfb\u3092\u9084\u5143\u7684\u306b\u9032\u3081\u308b\u9175\u7d20\u306f\u5b58\u5728\u3057\u306a\u3044\u3002\u3053\u308c\u304c\u3001\u672c\u6765\u306eChlorophyll b\u304cChlorophyllide a\u306e\u9178\u5316\u5206\u89e3\u7269\u3067\u3042\u308a\u3001\u4f8b\u3048chlorophyll a\u3078\u5411\u304b\u3046\u7cfb\u304c\u5b58\u5728\u3059\u308b\u306b\u3057\u3066\u3082chlorophyll a\u751f\u5408\u6210\u306e\u672c\u6765\u306e\u524d\u99c6\u4f53\u3067\u306f\u306a\u3044\u3068\u8ff0\u3079\u305f\u7406\u7531\u3067\u3042\u308b\u3002<\/p>\n\n\n\n

\u3000\u591a\u5206\u3053\u3053\u307e\u3067\u306e\u8a71\u306b\u5bfe\u3057\u3001\u3055\u307b\u3069\u306e\u7570\u898b\u304c\u3042\u308b\u3068\u306f\u601d\u308f\u306a\u3044\u3002\u79c1\u81ea\u8eab\u3001\u3053\u306e\u307e\u307e\u8ad6\u3092\u9032\u3081\u3088\u3046\u3068\u3057\u305f\u306e\u3060\u304c\u3001\u3088\u304f\u8003\u3048\u3066\u307f\u308b\u3068\u300c\u307e\u3068\u3081\u30b5\u30a4\u30c8\u300d\u306e\u7f60\u306b\u5d4c\u3063\u3066\u3044\u305f\u3053\u3068\u306b\u6c17\u3065\u3044\u305f\u3002\u305d\u308c\u304c\u3001\u66f4\u65b0\u304c\u9045\u308c\u305f\u4e00\u3064\u306e\u7406\u7531\u3067\u3042\u308b\u3002\u3053\u3053\u307e\u3067\u306e\u8b70\u8ad6\u306fKEGG\u306e\u201cPorphyrin and chlorophyll metabolism – Reference pathway\u201d\u306e\u30da\u30fc\u30b8\u3092\u53c2\u7167\u3057\u306a\u304c\u3089\u306e\u8a71\u3067\u3042\u308b\u3002\u3053\u3053\u306b\u554f\u984c\u304c\u5b58\u5728\u3059\u308b\u3002\u30ac\u30b9\u30af\u30ed\u30de\u30c8\u30b0\u30e9\u30d5\u30a3\u30fc\u5206\u6790\u3067\u5f97\u3089\u308c\u308b\u30af\u30ed\u30de\u30c8\u30b0\u30e9\u30e0\u304c\u5358\u306bretention time\u306b\u7531\u6765\u3059\u308b\u4e8c\u6b21\u5143\u306e\u30c7\u30fc\u30bf\u3067\u3042\u308b\u306e\u306b\u5bfe\u3057\u3001GCMS\u3084LCMS\u3067\u5f97\u3089\u308c\u308b\u30c8\u30fc\u30bf\u30eb\u30a4\u30aa\u30f3\u30af\u30ed\u30de\u30c8\u30b0\u30e9\u30e0\u306f\u3001\u3042\u308bretention time\u3092\u6301\u3064\u30d4\u30fc\u30af\u306e\u5f8c\u308d\u306b\u30de\u30b9\u30b9\u30da\u30af\u30c8\u30eb\u304c\u96a0\u308c\u3066\u3044\u308b\u4e09\u6b21\u5143\u306e\u30c7\u30fc\u30bf\u3067\u3042\u308b\u3088\u3046\u306b\u3001\u201cPorphyrin and chlorophyll metabolism – Reference pathway\u201d\u306e\u30da\u30fc\u30b8\u306f\u3001\u771f\u6838\u751f\u7269346\u7a2e\u3001\u30d0\u30af\u30c6\u30ea\u30a23,900\u7a2e\u3001\u53e4\u7d30\u83cc231\u7a2e\u306e\u30c7\u30fc\u30bf\u304c\u91cd\u5c64\u3057\u3066\u6295\u5f71\u3055\u308c\u305f\u69cb\u9020\u306b\u306a\u3063\u3066\u3044\u308b\u3002\u3068\u3059\u308c\u3070\u3001\u305d\u306e\u751f\u7269\u4e00\u3064\u4e00\u3064\u306e\u6301\u3064\u4ee3\u8b1d\u7cfb\u306f\u7570\u306a\u3063\u3066\u3044\u308b\u304c\u6545\u306b\u3001\u300c\u3053\u306e\u56f3\u306b\u304a\u3044\u3066\u306fCoproporphyrinogen III\u304b\u3089Protoporphyrinogen IX\u3078\u306e\u5909\u63db\u306b\u304a\u3044\u3066\u50cd\u304fEC3.3.3\uff08coproporphyrinogen III oxidase\uff09\u3068Protoporphyrinogen IX\u304b\u3089Protoporphyrin IX\u3067\u50cd\u304fEC 1.3.3.4\uff08protoporphyrinogen IX oxidase\uff09\u304c\u9178\u7d20\u5206\u5b50\u3092\u5229\u7528\u3059\u308b\u9175\u7d20\u3067\u3042\u308b\u304c\u3001\u524d\u6bb5\u306e\u53cd\u5fdc\u306b\u306foxygen-independent coproporphyrinogen III oxidase [EC:1.3.98.3]\u3001\u5f8c\u6bb5\u306e\u53cd\u5fdc\u306b\u306fmenaquinone-dependent protoporphyrinogen oxidase [EC:1.3.5.3]\u3068\u3044\u3046\u9178\u7d20\u3092\u5fc5\u8981\u3068\u3057\u306a\u3044\u9175\u7d20\u304c\u540c\u3058\u53cd\u5fdc\u3092\u89e6\u5a92\u3059\u308b\u3002\u3064\u307e\u308a\u3001\u9178\u7d20\u306e\u95a2\u4e0e\u306a\u3057\u306b\u30d7\u30ed\u30c8\u30dd\u30eb\u30d5\u30a3\u30ea\u30f3IX\u307e\u3067\u9032\u884c\u3059\u308b\u7cfb\u304c\u3042\u308b\u3044\u3046\u308f\u3051\u3067\u3042\u308b\u3002\u300d\u306a\u3069\u3068\u3044\u3046\u7267\u6b4c\u7684\u306a\u89e3\u91c8\u3067\u826f\u3044\u306f\u305a\u304c\u306a\u3044\u3002<\/p>\n\n\n\n

\u3000\u3064\u307e\u308a\u3001\u3069\u306e\u751f\u7269\u304c\u4e0a\u8a18\u306e\u7d50\u8ad6\u3092\u652f\u6301\u3059\u308b\u4ee3\u8b1d\u7cfb\u3092\u6301\u3061\u3001\u304b\u3064\u305d\u306e\u751f\u7269\u304c\u7cfb\u7d71\u6a39\u306b\u304a\u3044\u3066\u3053\u306e\u7d50\u8ad6\u306b\u76f8\u5fdc\u3059\u308b\u5834\u6240\u306b\u4f4d\u7f6e\u3059\u308b\u306e\u304b\u3068\u3044\u3046\u554f\u984c\u306b\u906d\u9047\u3059\u308b\u308f\u3051\u3067\u3042\u308b\u3002\u305d\u3046\u3059\u308b\u3068\u3001\u3053\u306e\u6642\u70b9\u3067\u5148\u8ff0\u3057\u305f\u30d8\u30e0\u30bf\u30f3\u30d1\u30af\u8cea\u3001\u30af\u30ed\u30ed\u30d5\u30a3\u30eb\u3001\u30b7\u30a2\u30ce\u30b3\u30d0\u30e9\u30df\u30f3\u3078\u5411\u304b\u3046\u4ee3\u8b1d\u7cfb\u767a\u9054\u306e\u9806\u5e8f\u554f\u984c\u304c\u8d77\u3053\u3063\u3066\u304f\u308b\u306e\u3067\u3042\u308b\u3002<\/p>\n\n\n\n

\u30001986\u5e74\u306b\u30a6\u30a9\u30eb\u30bf\u30fc\u30fb\u30ae\u30eb\u30d0\u30fc\u30c8\u306b\u3088\u3063\u3066\u63d0\u5531\u3055\u308c\u305fRNA\u30ef\u30fc\u30eb\u30c9\u4eee\u8aac\u3068\u547c\u3070\u308c\u308b\u8aac\u304c\u3042\u308b\u3002\u3044\u308f\u3086\u308b\u539f\u521d\u306e\u5730\u7403\u4e0a\u306b\u907a\u4f1d\u60c5\u5831\u3068\u9175\u7d20\u6d3b\u6027\u3092\u4f75\u305b\u6301\u3064RNA\u304b\u3089\u306a\u308b\u81ea\u5df1\u8907\u88fd\u7cfb\u304c\u3042\u3063\u305f\u3068\u3059\u308b\u4eee\u8aac\u3067\u3042\u308b\u3002\u3044\u307e\u3053\u3053\u3067\u3001\u3053\u306e\u8aac\u3092\u3069\u3046\u306b\u304b\u3057\u3088\u3046\u306a\u3069\u3068\u8003\u3048\u3066\u3044\u308b\u308f\u3051\u3067\u306f\u306a\u3044\u3002\u305f\u3060RNA\u3068DNA\u306f\u3069\u3061\u3089\u304c\u53e4\u3044\u306e\u3060\u308d\u3046\u304b\u3068\u601d\u3063\u305f\u3060\u3051\u3060\u3002<\/p>\n\n\n\n

\u3000\u7d50\u8ad6\u306f\u7c21\u5358\u3067\u3001RNA\u306e\u65b9\u304c\u53e4\u3044\u3068\u8003\u3048\u3066\u9593\u9055\u3044\u306f\u306a\u3044\u3060\u308d\u3046\u3002\u7406\u7531\u306fDNA\u3092\u69cb\u6210\u3059\u308b\u30c1\u30df\u30f3\u3068\u30c7\u30aa\u30ad\u30b7\u30ea\u30dc\u30fc\u30b9\u304c\u3001\u305d\u308c\u305e\u308c\u30a6\u30e9\u30b7\u30eb\u3068\u30ea\u30dc\u30fc\u30b9\u306b\u7531\u6765\u3059\u308b\u3053\u3068\u3092\u8003\u3048\u308c\u3070\u6e08\u3080\u8a71\u3067\u3042\u308b\u3002\u30dd\u30eb\u30d5\u30a3\u30ea\u30f3\u306e\u8a71\u3092\u3057\u3066\u3044\u308b\u306e\u306b\u4f55\u304b\u95a2\u4fc2\u3067\u3082\u3042\u308b\u306e\u304b\u3068\u8a1d\u3057\u3080\u4eba\u3082\u3044\u308b\u304b\u3068\u601d\u3046\u304c\u3001\u5b9f\u306f\u307b\u3068\u3093\u3069\u898b\u3048\u306a\u3044\u3068\u306f\u8a00\u3048\u6df1\u3044\u95a2\u4fc2\u304c\u5b58\u5728\u3059\u308b\u306e\u3067\u3042\u308b\u3002\u307e\u305a\u3001\u30a6\u30e9\u30b7\u30eb\u304b\u3089\u30c1\u30df\u30f3\u3078\u306e\u5909\u63db\u3001\u6b63\u3057\u304f\u8a00\u3048\u3070dUMP\uff08\u30c7\u30aa\u30ad\u30b7\u30a6\u30e9\u30b7\u30eb\u30e2\u30ce\u30ea\u30f3\u9178\uff09\u304b\u3089\uff44TMP\uff08\u30c7\u30aa\u30ad\u30b7\u30c1\u30df\u30b8\u30eb\u30e2\u30ce\u30ea\u30f3\u9178\uff09\u3078\u306e\u5909\u63db\u306b\u304a\u3044\u3066\u30015,10-Methylenetetrahydrofolate:dUMP C-methyltransferase\u306e\u5b58\u5728\u5316\u306b\u88dc\u9175\u7d20\u3067\u3042\u308b5,10-Methylenetetrahydrofolate\u304b\u30891\u70ad\u7d20\u304c\uff44UMP\u3078\u3068\u8ee2\u79fb\u3057\u3066\uff44TMP\u304c\u751f\u5408\u6210\u3055\u308c\u3066\u3044\u308b\u3053\u3068\u3092\u898b\u308c\u3070\u3001\u30a6\u30e9\u30b7\u30eb\u3092\u6838\u9178\u5869\u57fa\u3068\u3057\u3066\u542b\u3080RNA\u304c\u5148\u884c\u3059\u308b\u3068\u8003\u3048\u3066\u9593\u9055\u3044\u306a\u3044\u3067\u3042\u308d\u3046\u3002\u3053\u306e\u7d50\u679c\u306f\u30ea\u30dc\u30fc\u30b9\u3068\u3067\u30aa\u30ad\u30b7\u30ea\u30dc\u30fc\u30b9\u306e\u9593\u3067\u5f97\u3089\u308c\u308b\u63a8\u8ad6\u3068\u77db\u76fe\u3057\u306a\u3044\u3002<\/p>\n\n\n\n

\u904e\u5270\u3068\u8569\u5c3d28\u306b\u7d9a\u304f<\/p>\n","protected":false},"excerpt":{"rendered":"

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