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\n\u89e3\u7cd6\u7cfb\uff08\u30b0\u30ea\u30b3\u30ea\u30b7\u30b9\uff09\u306b\u3064\u3044\u3066\u306e\u8aac\u660e\u3092\u8aad\u3080\u3068\u3001\u30d2\u30c8\u306e\u7acb\u5834\u304b\u3089\u306e\u8a8d\u8b58\u3060\u306a\u3068\u611f\u3058\u308b\u3002\u4f55\u3057\u308d\u3001\u30b0\u30eb\u30b3\u30fc\u30b9\u304c\u51fa\u767a\u7269\u8cea\u3067\u3042\u308a\u30d4\u30eb\u30d3\u30f3\u9178\u304c\u751f\u6210\u7269\u3068\u5b9a\u7fa9\u3057\u3066\u3042\u308b\u3002\u30d2\u30c8\u304c\u30d2\u30c8\u306e\u7acb\u5834\u304b\u3089\u8003\u3048\u3066\u4f55\u304c\u60aa\u3044\u3068\u554f\u308f\u308c\u308b\u304b\u3082\u3057\u308c\u306a\u3044\u3002\u3053\u306e\u6349\u3048\u65b9\u3092\u5426\u5b9a\u306f\u3057\u306a\u3044\u304c\u3001\u30d2\u30c8\u306e\u7acb\u5834\u3067\u898b\u305f\u89e3\u7cd6\u7cfb\u304c\u3042\u308b\u306e\u3067\u3042\u308c\u3070\u3001\u30d0\u30af\u30c6\u30ea\u30a2\u306e\u7acb\u5834\u3067\u898b\u305f\u89e3\u7cd6\u7cfb\u3001\u53e4\u7d30\u83cc\u306e\u7acb\u5834\u304b\u3089\u898b\u305f\u89e3\u7cd6\u7cfb\u306a\u3069\u304c\u3001\u540c\u3058\u30d2\u30a8\u30e9\u30eb\u30ad\u30fc\u4e0a\u306b\u3042\u3063\u3066\u3082\u304a\u304b\u3057\u304f\u306f\u306a\u3044\u3002\u79c1\u306e\u7acb\u5834\u306f\u3001\u30d2\u30c8\u306e\u8996\u5ea7\u3092\u7d76\u5bfe\u5316\u305b\u305a\u306b\u3001\u76f8\u5bfe\u5316\u3057\u305f\u8996\u5ea7\u304b\u3089\u89e3\u7cd6\u7cfb\u3092\u773a\u3081\u305f\u3089\u3044\u304b\u306a\u308b\u98a8\u666f\u304c\u898b\u3048\u308b\u304b\u8003\u3048\u307e\u3057\u3087\u3046\u3068\u4e91\u3046\u7acb\u5834\u3067\u3042\u308b\u3002
\n\u3044\u304d\u306a\u308a\u71b1\u6c34\u5674\u51fa\u53e3\u5468\u8fba\u306b\u751f\u304d\u308b\u5fae\u751f\u7269\u306e\u8a71\u306b\u623b\u308b\u3053\u3068\u306b\u3059\u308b\u3002\u524d\u3005\u56de\u306b\u79c1\u306f\u3001\u300c\u70ad\u7d20\u6e90\u3092\u4e8c\u9178\u5316\u70ad\u7d20\u306b\u6c42\u3081\u308b\u304b\u3001\u305d\u308c\u3068\u3082\u30de\u30f3\u30c8\u30eb\u304b\u3089\u6e67\u51fa\u3059\u308b\u70ad\u5316\u6c34\u7d20\u306b\u6c42\u3081\u308b\u304b\u304c\u554f\u984c\u3060\u3068\u306f\u601d\u3046\u304c\u3001\u3044\u305a\u308c\u306b\u3057\u3066\u3082\u6804\u990a\u6e90\u306f\u5341\u5206\u306b\u3042\u308b\u6761\u4ef6\u4e0b\u306b\u751f\u7269\u306e\u767a\u751f\u306f\u8d77\u3053\u3063\u305f\u3068\u8003\u3048\u308b\u300d\u3068\u66f8\u3044\u305f\u3002\u500b\u4eba\u7684\u306b\u306f\u4e8c\u9178\u5316\u70ad\u7d20\u304c\u70ad\u7d20\u6e90\u3067\u3042\u308b\u3068\u601d\u3063\u3066\u3044\u308b\u3002\u4f55\u6545\u306a\u3089\u3070\u3001\u5206\u5b50\u7cfb\u7d71\u6a39\u306e\u6839\u672c\u4ed8\u8fd1\u306b\u3044\u308b\u771f\u6b63\u7d30\u83cc\u3067\u3042\u308bAquifex\u3001Thermotoga\u3001\u53ca\u3073\u53e4\u7d30\u83cc\u3067\u3042\u308bThermoproteus\u3001Thermococcus\u306b\u5c5e\u3059\u308b\u7d30\u83cc\u985e\u306e\u4e2d\u3067\u3001\u72ec\u7acb\u6804\u990a\u3092\u55b6\u3080Thermotoga\u3068Thermoproteus\u3001\u305d\u3057\u3066\u5316\u5b66\u5408\u6210\u72ec\u7acb\u6804\u990a\u3092\u55b6\u3080Thermococcus\u306e\u4ef2\u9593\u304c\u3001\u9162\u9178\u304b\u3089\u3064\u304f\u3089\u308c\u308b\u30a2\u30bb\u30c1\u30ebCoA\u3092\u7528\u3044\u3066\u4e8c\u9178\u5316\u70ad\u7d20\u3092\u56fa\u5b9a\u3059\u308b\u7cfb\u8def\u3068\u3068\u3082\u306b\u3001\u5f97\u3089\u308c\u308b\u30d4\u30eb\u30d3\u30f3\u9178\u306b\u3082\u30461\u5206\u5b50\u306e\u4e8c\u9178\u5316\u70ad\u7d20\u3092\u56fa\u5b9a\u3057\u3066\u30ea\u30f3\u30b4\u9178\u3092\u751f\u5408\u6210\u3059\u308b\u7cfb\u8def\u3092\u6301\u3064\u304b\u3089\u3067\u3042\u308b\u3002\u8981\u3059\u308b\u306b\u3001\u3053\u308c\u3089\u306e\u83cc\u306f\u70ad\u7d20\u5316\u5408\u7269\u306e\u4ee3\u8b1d\u3092\u9162\u9178\u304b\u3089\u51fa\u767a\u3055\u305b\u3066\u3044\u308b\u3068\u4e91\u3063\u3066\u3088\u3044\u3002\u3068\u3059\u308c\u3070\u3001\u3053\u308c\u3089\u306e\u83cc\u4f53\u5185\u3067\u5148\u306b\u52d5\u304f\u306e\u306f\u7cd6\u65b0\u751f\u7cfb\u3067\u3042\u308b\u3053\u3068\u306f\u81ea\u660e\u306e\u3053\u3068\u3060\u308d\u3046\u3002\u7cd6\u65b0\u751f\u7cfb\u3067\u591a\u7cd6\u985e\u304c\u3001\u3042\u308b\u3044\u306f\u30b0\u30eb\u30b3\u30fc\u30b9\u304c\u5408\u6210\u3055\u308c\u305f\u5f8c\u3067\u3001\u305d\u306e\u9006\u53cd\u5fdc\u3068\u3057\u3066\u306e\u89e3\u7cd6\u7cfb\u304c\u6a5f\u80fd\u3057\u59cb\u3081\u305f\u3068\u8003\u3048\u308b\u3079\u304d\u3067\u3042\u308d\u3046\u3002\u3053\u3046\u3057\u305f\u8996\u5ea7\u304b\u3089KEGG\u306e\u8aac\u660e\u6587\u3092\u8aad\u3080\u3068\u30012\u3064\u306e\u7cfb\u306e\u95a2\u4fc2\u304c\u9006\u8ee2\u3057\u3066\u3044\u308b\u3068\u3057\u304b\u601d\u3048\u306a\u3044\u3002\u72ec\u7acb\u6804\u990a\u7d30\u83cc\u306f\u30a2\u30bb\u30c1\u30ebCoA\u3068\u3057\u3066\u3001\u3044\u3084\u30b0\u30ea\u30b3\u30ea\u30b7\u30b9\u3067\u3042\u308c\u3070\u30d4\u30eb\u30d3\u30f3\u9178\u3068\u3057\u3066\u521d\u767a\u7269\u8cea\u3092\u6295\u5165\u3059\u308b\u306e\u3067\u3042\u308b\u3002\u305d\u306e\u7d50\u679c\u3001\u30d4\u30eb\u30d3\u30f3\u9178\u306e\u4e00\u90e8\u306f\u7cd6\u65b0\u751f\u7cfb\u3092\u901a\u3063\u3066\u591a\u7cd6\u985e\u3078\u3068\u6d41\u308c\u3001\u307e\u305f\u4e00\u90e8\u306f\u3055\u3089\u306b1\u5206\u5b50\u306e\u4e8c\u9178\u5316\u70ad\u7d20\u3092\u56fa\u5b9a\u3057\u30ea\u30f3\u30b4\u9178\u3078\u3068\u5909\u63db\u3055\u308c\u308b\u306e\u3067\u3042\u308b\u3002\u3053\u3046\u3057\u305f\u7406\u89e3\u304b\u3089\u79c1\u304c2\u3064\u306e\u7cfb\u3092\u8aac\u660e\u3059\u308b\u3068\u3059\u308c\u3070\u3001
\n\u300c\u30b0\u30eb\u30b3\u30cd\u30aa\u30b8\u30a7\u30cd\u30b7\u30b9\u306f\u30d4\u30eb\u30d3\u30f3\u9178\u3092\u591a\u7cd6\u306b\u5909\u63db\u3059\u308b\u30d7\u30ed\u30bb\u30b9\u3067\u3042\u308a\u3001\u5c11\u91cf\u306eATP(\u30a8\u30cd\u30eb\u30ae\u30fc)\u3068NADH(\u9084\u5143\u529b)\u3092\u6d88\u8cbb\u3059\u308b\u3002\u305d\u308c\u306f\u91cd\u8981\u306a\u4ee3\u8b1d\u524d\u99c6\u4f53\u7fa4\uff1a6\u70ad\u7d20\u5316\u5408\u7269\u3067\u3042\u308b\u30b0\u30eb\u30b3\u30fc\u30b9-6-\u30ea\u30f3\u9178\u3068\u30d5\u30eb\u30af\u30c8\u30fc\u30b9-6-\u30ea\u30f3\u9178\u3001\u53ca\u30733-\u70ad\u7d20\u5316\u5408\u7269\u3067\u3042\u308b\u30b0\u30ea\u30bb\u30ed\u30f3-\u30ea\u30f3\u9178\u3001\u30b0\u30ea\u30bb\u30eb\u30a2\u30eb\u30c7\u30d2\u30c9-3-\u30ea\u30f3\u9178\u30013-\u30db\u30b9\u30db\u30b0\u30ea\u30bb\u30ea\u30f3\u9178\u3001\u305d\u3057\u3066\u30db\u30b9\u30db\u30a8\u30ce\u30fc\u30eb\u30d4\u30eb\u30d3\u30f3\u9178\u3092\u751f\u7523\u3059\u308b\u4e2d\u5fc3\u7cfb\u8def\u3067\u3042\u308b\u3002\u53cd\u5fdc\u306e\u51fa\u767a\u7269\u8cea\u3067\u3042\u308b\u30d4\u30eb\u30d3\u30f3\u9178\u306f\u3001\u3082\u3046\u4e00\u3064\u306e\u91cd\u8981\u306a\u4ee3\u8b1d\u524d\u99c6\u4f53\u3067\u3042\u308b\u30a2\u30bb\u30c1\u30ebCoA\u304b\u3089\u30d5\u30a7\u30ec\u30c9\u30ad\u30b7\u30f3\u3092\u88dc\u9175\u7d20\u3068\u3059\u308b\u70ad\u7d20\u56fa\u5b9a\u53cd\u5fdc\u306b\u3088\u308a\u4f9b\u7d66\u3055\u308c\u308b\u3002\u30b0\u30ea\u30b3\u30ea\u30b7\u30b9\u306f\u5f93\u5c5e\u6804\u990a\u751f\u7269\u306b\u5206\u5e03\u3059\u308b\u30b0\u30eb\u30b3\u30fc\u30b9\u3092\u30d4\u30eb\u30d3\u30f3\u9178\u307e\u3067\u5206\u89e3\u3059\u308b\u7cfb\u8def\u3067\u3001\u4e3b\u306b\u5f93\u5c5e\u6804\u8a89\u751f\u7269\u3067\u6a5f\u80fd\u3059\u308b\u7cfb\u8def\u3067\u3042\u308b\u3002\u3053\u306e\u7cfb\u8def\u306f\u3001\u3044\u304f\u3064\u304b\u306e\u5225\u53cd\u5fdc\u3092\u542b\u3080\u306b\u3057\u308d\u3001\u672c\u8cea\u7684\u306b\u306f\u30b0\u30ea\u30b3\u30cd\u30aa\u30b8\u30a7\u30cd\u30b7\u30b9\u306e\u9006\u53cd\u5fdc\u3067\u3042\u308b\u3002\u300d\u3068\u306a\u308b\u3002
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