{"id":5460,"date":"2015-01-23T15:33:58","date_gmt":"2015-01-23T06:33:58","guid":{"rendered":"http:\/\/bamlab.ok-japan.com\/?p=5460"},"modified":"2019-11-01T15:34:18","modified_gmt":"2019-11-01T06:34:18","slug":"%e6%ad%b4%e5%8f%b2%e7%94%9f%e7%89%a9%e5%ad%a6%e3%83%bb%e3%83%bb%e3%83%bb%e4%b8%80%e6%ac%a1%e4%bb%a3%e8%ac%9d%e3%81%a8%e4%ba%8c%e6%ac%a1%e4%bb%a3%e8%ac%9d%e3%80%8010%e3%80%80","status":"publish","type":"post","link":"https:\/\/bamboolab.yamasatoagr.com\/?p=5460","title":{"rendered":"\u6b74\u53f2\u751f\u7269\u5b66\u30fb\u30fb\u30fb\u4e00\u6b21\u4ee3\u8b1d\u3068\u4e8c\u6b21\u4ee3\u8b1d\u300010\u3000"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">\u3000\u3000\u3068\u306f\u3044\u3048\u3001\u85ac\u5b66\u306e\u7814\u7a76\u8005\u9054\u3082\u3001\u30e2\u30eb\u30d2\u30cd\u306e\u5b58\u5728\u610f\u7fa9\u306e\u8aac\u660e\u306e\u96e3\u3057\u3055\u3092\u5589\u306b\u523a\u3055\u3063\u305f\u5c0f\u9aa8\u306e\u3088\u3046\u306b\u611f\u3058\u3066\u3044\u305f\u306e\u3067\u306f\u306a\u3044\u3060\u308d\u3046\u304b\u3002\u30e2\u30eb\u30d2\u30cd\u306f\u30aa\u30d4\u30aa\u30a4\u30c9\u306e\u03bc\u53d7\u5bb9\u4f53\u306b\u7d50\u5408\u3059\u308b\u306e\u3060\u304c\u3001\u54fa\u4e73\u985e\u306b\u304a\u3044\u3066\u03bc\u53d7\u5bb9\u4f53\u306b\u7d50\u5408\u3059\u308b\u5185\u56e0\u6027\u30ea\u30ac\u30f3\u30c9\u306f\u898b\u51fa\u3055\u308c\u3066\u3044\u306a\u3044\u3002\u5185\u56e0\u6027\u30ea\u30ac\u30f3\u30c9\u3092\u6301\u305f\u306a\u3044\u3001\u3044\u308f\u3086\u308b\u30aa\u30fc\u30d5\u30a1\u30f3\u30ec\u30bb\u30d7\u30bf\u30fc\u306b\u3001\u4eba\u306a\u3089\u306c\u30b1\u30b7\u304c\u3064\u304f\u308b\u30e2\u30eb\u30d2\u30cd\u304c\u7d50\u5408\u3057\u3066\u9855\u8457\u306a\u751f\u7406\u4f5c\u7528\u3092\u793a\u3059\u3068\u3044\u3046\u73fe\u5b9f\u3092\u3001\u4e0a\u624b\u304f\u8aac\u660e\u3059\u308b\u3053\u3068\u306f\u306a\u304b\u306a\u304b\u96e3\u3057\u3044\u306b\u9055\u3044\u306a\u3044\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3000\u3000\u3053\u306e\u72b6\u6cc1\u3092\u4f55\u3068\u304b\u6253\u7834\u3057\u3088\u3046\u3068\u3059\u308b\u52d5\u304d\u306f1970\u5e74\u4ee3\u304b\u3089\u3042\u3063\u305f\u3002\u30b1\u30b7\u304c\u4f55\u6545\u30e2\u30eb\u30d2\u30cd\u3092\u3064\u304f\u308b\u304b\u306f\u6a2a\u306b\u7f6e\u304f\u3068\u3057\u3066\u3082\u3001\u30e2\u30eb\u30d2\u30cd\u304c\u54fa\u4e73\u985e\u306e\u4f53\u5185\u3067\u751f\u5408\u6210\u3055\u308c\u308b\u3053\u3068\u3092\u8a3c\u660e\u3057\u3066\u3001\u5c11\u306a\u304f\u3068\u3082\u30e2\u30eb\u30d2\u30cd\u3092\u5185\u56e0\u6027\u30ea\u30ac\u30f3\u30c9\u3068\u3057\u3066\u4f4d\u7f6e\u3065\u3051\u3088\u3046\u3068\u3044\u3046\u308f\u3051\u3067\u3042\u308b\u3002\u3053\u308c\u304c\u3001Davis \u3068Walsh \u306b\u3088\u308a\u63d0\u5531\u3055\u308c\u305f\u30e2\u30eb\u30d2\u30cd\u5185\u56e0\u6027\u30ea\u30ac\u30f3\u30c9\u4eee\u8aac\u3067\u3042\u308d\u3046\u300a<em>Science<\/em>, <strong>167<\/strong>, 1005-1007, (1970)\u300b\u3002\u305d\u306e\u5f8c\u3001Hazum \u300a<em>Science<\/em>, <strong>213<\/strong>, 1010-1012 (1981)\u300b\u3089\u306f\u3001\u30d2\u30c8\u304a\u3088\u3073\u30a6\u30b7\u306e\u6bcd\u4e73\u304b\u3089\u30e2\u30eb\u30d2\u30cd\u306e\u5358\u96e2\u306b\u6210\u529f\u3057\u305f\u306e\u3060\u304c\uff0c\u3053\u308c\u306f\u98df\u7269\u7531\u6765\u3067\u3042\u308b\u53ef\u80fd\u6027\u304c\u9ad8\u3044\u3068\u5224\u65ad\u3055\u308c\u3001\u3053\u306e\u4eee\u8aac\u306e\u8a3c\u660e\u3068\u306f\u8a8d\u3081\u3089\u308c\u3089\u306a\u304b\u3063\u305f\u3088\u3046\u3060\u304c\u3001\u3053\u306e\u30e2\u30eb\u30d2\u30cd\u5185\u56e0\u6027\u30ea\u30ac\u30f3\u30c9\u4eee\u8aac\u306f\u751f\u304d\u7d9a\u3051\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3000\u3000\u305d\u3057\u30661986\u5e74\u306b\u306fGoldstein \u300a<em>Proc. Natl. Acad. Sci. USA<\/em>., <strong>83,<\/strong> 9784-978 (1986)\u300b\u3089\u304c\u30a6\u30b7\u8133\u5185\u306b\u30e2\u30eb\u30d2\u30cd\u3084\u305d\u306e\u524d\u99c6\u7269\u8cea\u3067\u3042\u308b\u30b3\u30c7\u30a4\u30f3\u306e\u5b58\u5728\u3092\u78ba\u8a8d\u3057\u305f\u3060\u3051\u3067\u306a\u304f\u3001Spector\u300a<em>Proc. Natl. Acad. Sci. USA<\/em>., 83, 4566-4567\uff081986\uff09\u300b\u3089\u306f\u3001\u30b3\u30c7\u30a4\u30f3\u3084\u305d\u306e\u524d\u99c6\u7269\u8cea\u3068\u8003\u3048\u3089\u308c\u308b\u30b5\u30eb\u30bf\u30ea\u30b8\u30f3\uff0c\u30c6\u30d0\u30a4\u30f3\u3092\u30e9\u30c3\u30c8\u306b\u6295\u4e0e\u3059\u308b\u3068\u8133\u3092\u542b\u3080\u69d8\u3005\u306a\u81d3\u5668\u3067\u30e2\u30eb\u30d2\u30cd\u91cf\u304c\u5897\u52a0\u3059\u308b\u3053\u3068\u3092\u5831\u3058\u3066\u3044\u308b\u3002\u305d\u306e\u5f8c\u3001Matsubara\u300a<em>J. Pharmacol. Exp. Ther<\/em>., <strong>260<\/strong>, 974-978\uff081992\uff09\u300b\u3089\u306f\u3001L-\u30c9\u30fc\u30d1\u306e\u85ac\u7269\u6cbb\u7642\u3092\u53d7\u3051\u3066\u3044\u308b\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\u60a3\u8005\u306e\u5c3f\u4e2d\u3067\u306f\u30e2\u30eb\u30d2\u30cd\u304a\u3088\u3073\u30b3\u30c7\u30a4\u30f3\u91cf\u304c\u4e0a\u6607\u3059\u308b\u3053\u3068\u3092\u5831\u544a\u3057\u3001Stefano \u306e\u30b0\u30eb\u30fc\u30d7\u300a<em>MolBrain Res<\/em>., <strong>117<\/strong>, 83-90 (2003)\u300b\u304c\u3001\u6700\u5f8c\u306b\u6b8b\u3063\u3066\u3044\u305f\u524d\u99c6\u7269\u8cea\u3067\u3042\u308b\u30ec\u30c1\u30af\u30ea\u30f3\u3092\u30e9\u30c3\u30c8\u8133\u5185\u3067\u691c\u51fa\uff0812.7\u00b15.4 ng\/g wet tissue\uff09\u306b\u6210\u529f\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3000\u3000\u3053\u3053\u3067L-DOPA\u304b\u3089\u30e2\u30eb\u30d2\u30cd\u307e\u3067\u306e\u751f\u5408\u6210\u7d4c\u8def\u306f\u5b8c\u5168\u306b\u3064\u306a\u304c\u3063\u305f\u3060\u3051\u3067\u306a\u304f\u3001\u54fa\u4e73\u52d5\u7269\u306b\u304a\u3051\u308b\u751f\u5408\u6210\u7cfb\u304c\u30b1\u30b7\u306e\u751f\u5408\u6210\u7cfb\u3068\u540c\u69d8\u3067\u3042\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u305f\u3002\u3053\u308c\u3089\u306e\u7d50\u679c\u3092\u3082\u3063\u3066\u3059\u308c\u3070\u3001\u4eba\u3082\u30e2\u30eb\u30d2\u30cd\u3092\u751f\u5408\u6210\u3067\u304d\u308b\u53ef\u80fd\u6027\u304c\u5341\u5206\u306b\u3042\u308b\u3068\u8a00\u3048\u308b\u3060\u308d\u3046\u3002\u30e2\u30eb\u30d2\u30cd\u304c\u54fa\u4e73\u52d5\u7269\u306b\u304a\u3044\u3066\u03bc\u53d7\u5bb9\u4f53\u306b\u7d50\u5408\u3059\u308b\u672c\u6765\u306e\u5185\u56e0\u6027\u30ea\u30ac\u30f3\u30c9\u3067\u3042\u308b\u3068\u7d50\u8ad6\u3065\u3051\u3066\u826f\u3044\u304b\u3069\u3046\u304b\u306f\u307e\u3060\u5206\u304b\u3089\u306a\u3044\u304c\u3001\u4f55\u3068\u304b\u3057\u3066\u30e2\u30eb\u30d2\u30cd\u3068\u4eba\u3092\u95a2\u4fc2\u3065\u3051\u3088\u3046\u3068\u3059\u308b\u52aa\u529b\u304c\u5b9f\u308a\u304b\u3051\u3066\u3044\u308b\u3068\u8a00\u3048\u308b\u304b\u3082\u3057\u308c\u306a\u3044\u3002\u300c\u306a\u305c\u30b1\u30b7\u306f\u30e2\u30eb\u30d2\u30cd\u3092\u3064\u304f\u308b\u306e\u304b\u300d\u3068\u3044\u3046\u7591\u554f\u306b\u7b54\u3048\u3066\u306f\u3044\u306a\u3044\u306b\u3057\u3066\u3082\u3060\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3000\u3000\u3053\u306e\u8a71\u3068\u5168\u304f\u88cf\u8fd4\u3057\u306e\u7269\u8a9e\u304c\u30a2\u30d6\u30b7\u30b8\u30f3\u9178\u306b\u3064\u3044\u3066\u3082\u5b58\u5728\u3059\u308b\u3002\u5947\u3057\u304f\u3082Spector\u3089\u304c\u3001\u30b3\u30c7\u30a4\u30f3\u3084\u305d\u306e\u524d\u99c6\u7269\u8cea\u3068\u8003\u3048\u3089\u308c\u308b\u30b5\u30eb\u30bf\u30ea\u30b8\u30f3\uff0c\u30c6\u30d0\u30a4\u30f3\u3092\u30e9\u30c3\u30c8\u306b\u6295\u4e0e\u3059\u308b\u3068\u8133\u3092\u542b\u3080\u69d8\u3005\u306a\u81d3\u5668\u3067\u30e2\u30eb\u30d2\u30cd\u91cf\u304c\u5897\u52a0\u3059\u308b\u3053\u3068\u3092\u5831\u3058\u305f1986\u5e74\u306b\u3001\u690d\u7269\u30db\u30eb\u30e2\u30f3\u3067\u3042\u308b\u30a2\u30d6\u30b7\u30b8\u30f3\u9178\u304c\u30d6\u30bf\u3084\u30e9\u30c3\u30c8\u306e\u8133\u306b\u5b58\u5728\u3059\u308b\u3068\u3044\u3046\u5831\u544a\u304c\u306a\u3055\u308c\u305f\u300aLe Page-Degivry MT <em>et al<\/em>., <em>Proc Natl Acad Sci U S A<\/em>., <strong>83<\/strong>(4),1155-8 (1986)\u300b\u3002\u30a2\u30d6\u30b7\u30b8\u30f3\u9178\u304c\u54fa\u4e73\u52d5\u7269\u306e\u8133\u5185\u306b\u5b58\u5728\u3059\u308b\u3068\u3044\u3046\u3053\u306e\u5831\u544a\u306b\u3001\u3084\u306f\u308a\u98df\u7269\u7531\u6765\u3067\u306f\u306a\u3044\u304b\u3068\u3044\u3046\u7591\u3044\u304c\u3064\u304d\u307e\u3068\u3063\u305f\u306e\u306f\u4ed5\u65b9\u306e\u306a\u3044\u3053\u3068\u3067\u3042\u3063\u305f\u308d\u3046\u3002\u3044\u3064\u9803\u30a2\u30d6\u30b7\u30b8\u30f3\u9178\u304c\u54fa\u4e73\u52d5\u7269\u306b\u304a\u3051\u308b\u5185\u751f\u306e\u7269\u8cea\u3067\u3042\u308b\u3068\u8a8d\u77e5\u3055\u308c\u305f\u306e\u304b\u306f\u5b9a\u304b\u3067\u306a\u3044\u304c\u3001\u690d\u7269\u30db\u30eb\u30e2\u30f3\u304c\u30d2\u30c8\u306e\u8133\u306b\u3042\u308b\u306a\u3069\u3068\u3044\u3046\u72b6\u6cc1\u306f\u5c45\u5fc3\u5730\u304c\u60aa\u304b\u3063\u305f\u3089\u3057\u304f\u3001\u54fa\u4e73\u52d5\u7269\u306b\u304a\u3051\u308b\u30a2\u30d6\u30b7\u30b8\u30f3\u9178\u306e\u5f71\u97ff\u306b\u3064\u3044\u3066\u306e\u7814\u7a76\u304c\u958b\u59cb\u3055\u308c\u305f\uff61<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3000\u3000\u305d\u306e\u7d50\u679c\u3001Bruzzone\u7b49\u300a<em>Proc. Natl. Acad. Sci. USA<\/em>&nbsp;<strong>104,<\/strong>&nbsp;5759-5764 (2007)\u300b\u306f\u3001\u30a2\u30d6\u30b7\u30b8\u30f3\u9178\u304c\u30d2\u30c8\u306e\u679c\u7c92\u7403\uff08\u767d\u8840\u7403\u306e\u4e00\u7a2e\uff09\u3092\u523a\u6fc0\u3059\u308b\u30b7\u30b0\u30ca\u30eb\u3068\u3057\u3066\u50cd\u3044\u3066\u3044\u308b\u3068\u5831\u3058\u305f\u3042\u3068\u3001\u5f7c\u3089\u306e\u30b0\u30eb\u30fc\u30d7\u304b\u3089\u306f\u30a4\u30f3\u30b9\u30ea\u30f3\u306e\u5206\u6ccc\u3092\u523a\u6fc0\u3059\u308b\u3068\u3044\u3046\u5831\u544a\u3082\u306a\u3055\u308c\u3066\u3044\u308b\u3002\u3055\u3089\u306b\u3060\u304c\u3001\u56fd\u7acb\u611f\u67d3\u75c7\u7814\u7a76\u6240\u306e\u6c38\u5b97\u3089\u306f\u3001\u539f\u866b\u3067\u3042\u308b\u30c8\u30ad\u30bd\u30d7\u30e9\u30ba\u30de\u304c\u30a2\u30d6\u30b7\u30b8\u30f3\u9178\u3092\u751f\u5408\u6210\u3057\u3001\u5bbf\u4e3b\u7d30\u80de\u304b\u3089\u306e\u8131\u51fa\u3092\u5236\u5fa1\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3059\u308b\u3068\u540c\u6642\u306b\u3001\u30a2\u30d6\u30b7\u30b8\u30f3\u9178\u751f\u5408\u6210\u963b\u5bb3\u5264\u3067\u3042\u308b\u30d5\u30eb\u30ea\u30c9\u30f3\u304c\u30c8\u30ad\u30bd\u30d7\u30e9\u30ba\u30de\u306e\u30de\u30a6\u30b9\u3078\u306e\u611f\u67d3\u3092\u6709\u610f\u306b\u6291\u3048\u308b\u3053\u3068\u3092\u5831\u3058\u3066\u3044\u308b\u3002\u300aNagamune, K., <em>et. al<\/em>., Nature , <strong>451<\/strong>, 207-10, (2008) \uff0cNagamune, K., <em>et al<\/em>., Comm. <em>Integ. Biol.<\/em> <strong>1<\/strong>, 62-65 (2008)\u300b\u3000\u6700\u5f8c\u306e\u30d5\u30eb\u30ea\u30c9\u30f3\u3092\u7528\u3044\u305f\u7d50\u679c\u306b\u3064\u3044\u3066\u306f\u3001\u963b\u5bb3\u4f4d\u7f6e\u304c\u30a2\u30d6\u30b7\u30b8\u30f3\u9178\u751f\u5408\u6210\u7cfb\u3068\u3055\u308c\u3066\u3044\u308b\u306b\u3057\u3066\u3082\u4ee3\u8b1d\u7cfb\u306e\u304b\u306a\u308a\u4e0a\u6d41\u306b\u3042\u308a\u3001\u30ab\u30ed\u30c6\u30ce\u30a4\u30c9\u751f\u5408\u6210\u963b\u5bb3\u306a\u3069\u3082\u8996\u91ce\u306b\u5165\u308c\u3066\u8003\u3048\u308b\u3079\u304d\u3067\u3042\u308d\u3046\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3000\u3000\u3068\u306f\u3044\u3048\u3053\u308c\u3089\u306e\u7d50\u679c\u3092\u898b\u308c\u3070\u3001\u3055\u3066\u30e2\u30eb\u30d2\u30cd\u306f\u305d\u3057\u3066\u30a2\u30d6\u30b7\u30b8\u30f3\u306f\u3044\u3063\u305f\u3044\u4f55\u8005\u3067\u3042\u308b\u306e\u304b\u3068\u306e\u7591\u554f\u3092\u8ab0\u3082\u304c\u6301\u3064\u3068\u601d\u3046\u306e\u3060\u304c\u3002\u3053\u306e\u7591\u554f\u306b\u62d8\u6ce5\u3057\u3066\u7814\u7a76\u306e\u624b\u3092\u6b62\u3081\u308b\u304b\u3069\u3046\u304b\u306f\u5225\u306b\u3057\u3066\u3082\u3060\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u6b74\u53f2\u751f\u7269\u5b66\u30fb\u30fb\u30fb\u4e00\u6b21\u4ee3\u8b1d\u3068\u4e8c\u6b21\u4ee3\u8b1d\u300011\u3000\u306b\u7d9a\u304f<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u3000\u3000\u3068\u306f\u3044\u3048\u3001\u85ac\u5b66\u306e\u7814\u7a76\u8005\u9054\u3082\u3001\u30e2\u30eb\u30d2\u30cd\u306e\u5b58\u5728\u610f\u7fa9\u306e\u8aac\u660e\u306e\u96e3\u3057\u3055\u3092\u5589\u306b\u523a\u3055\u3063\u305f\u5c0f &hellip; <a href=\"https:\/\/bamboolab.yamasatoagr.com\/?p=5460\">\u7d9a\u304d\u3092\u8aad\u3080 <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-5460","post","type-post","status-publish","format-standard","hentry","category-1"],"_links":{"self":[{"href":"https:\/\/bamboolab.yamasatoagr.com\/index.php?rest_route=\/wp\/v2\/posts\/5460","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/bamboolab.yamasatoagr.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/bamboolab.yamasatoagr.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/bamboolab.yamasatoagr.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/bamboolab.yamasatoagr.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=5460"}],"version-history":[{"count":1,"href":"https:\/\/bamboolab.yamasatoagr.com\/index.php?rest_route=\/wp\/v2\/posts\/5460\/revisions"}],"predecessor-version":[{"id":5461,"href":"https:\/\/bamboolab.yamasatoagr.com\/index.php?rest_route=\/wp\/v2\/posts\/5460\/revisions\/5461"}],"wp:attachment":[{"href":"https:\/\/bamboolab.yamasatoagr.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=5460"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/bamboolab.yamasatoagr.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=5460"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/bamboolab.yamasatoagr.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=5460"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}