{"id":5291,"date":"2021-07-19T01:10:55","date_gmt":"2021-07-18T16:10:55","guid":{"rendered":"http:\/\/bamlab.ok-japan.com\/?p=5291"},"modified":"2022-11-17T10:24:44","modified_gmt":"2022-11-17T01:24:44","slug":"%e6%ad%b4%e5%8f%b2%e7%94%9f%e7%89%a9%e5%ad%a6%e3%80%80tca%e5%9b%9e%e8%b7%af%e3%81%b8%e3%81%ae%e7%95%b0%e8%ab%96%e3%80%805","status":"publish","type":"post","link":"https:\/\/bamboolab.yamasatoagr.com\/?p=5291","title":{"rendered":"\u6b74\u53f2\u751f\u7269\u5b66\u3000TCA\u56de\u8def\u3078\u306e\u7570\u8ad6\u30005"},"content":{"rendered":"\n<p>\u3000\u8981\u3059\u308b\u306b\u3001\u5927\u3057\u305f\u3053\u3068\u3092\u4e91\u3063\u3066\u3044\u308b\u308f\u3051\u3067\u306f\u306a\u3044\u3002TCA\u56de\u8def\u3068\u96fb\u5b50\u4f1d\u9054\u7cfb\u306f\u5206\u3051\u3066\u8003\u3048\u308b\u3079\u304d\u3067\u3042\u308a\u3001\u305d\u306e\u5834\u5408\u306eTCA\u56de\u8def\u306f\u5acc\u6c17\u7684\u56de\u8def\u3068\u8003\u3048\u306a\u3044\u3068\u3001\u89e3\u7cd6\u7cfb\u306e\u5b9a\u7fa9\u306e\u3084\u308a\u65b9\u3068\u77db\u76fe\u3059\u308b\u3067\u306f\u306a\u3044\u304b\u3068\u3044\u3046\u6307\u6458\u3092\u3057\u3066\u3044\u308b\u3060\u3051\u3067\u3042\u308b\u3002\u305f\u3060\u3057\u3001\u3053\u308c\u3092\u8a8d\u3081\u308b\u3068\u4eca\u307e\u3067\u7d9a\u3044\u3066\u304d\u305fTCA\u56de\u8def\u3082\u3057\u304f\u306f\u89e3\u7cd6\u7cfb\u306b\u3064\u3044\u3066\u3001\u3069\u3061\u3089\u304b\u306e\u5b9a\u7fa9\u306e\u4fee\u6b63\u304c\u5fc5\u8981\u3068\u306a\u308b\u3002\u904e\u53bb\u306b\u51fa\u7248\u3055\u308c\u3066\u304d\u305f\u591a\u304f\u306e\u66f8\u7c4d\u3084\u5831\u544a\u306e\u4fee\u6b63\u306f\u3001JR\u306e\u99c5\u540d\u306e\u5909\u66f4\u306e\u3088\u3046\u306b\u3068\u3066\u3064\u3082\u306a\u304f\u5927\u5909\u306a\u4f5c\u696d\u3092\u4f34\u3046\u306e\u3067\u305d\u3093\u306a\u3053\u3068\u306f\u51fa\u6765\u306a\u3044\u306b\u9055\u3044\u306a\u3044\u3002\u4e07\u4e00\u8a8d\u3081\u3089\u308c\u305f\u3068\u3057\u3066\u3082\u3001\u300c\u307e\u3042\u305d\u3046\u3044\u3046\u7406\u89e3\u3082\u3042\u308b\u3088\u306d\u300d\u3068\u3044\u3046\u306a\u3093\u3068\u3082\u751f\u6e29\u3044\u5224\u65ad\u306e\u4e0b\u3067\u3001\u305d\u3063\u3068\u653e\u7f6e\u3055\u308c\u308b\u84cb\u7136\u6027\u304c\u9ad8\u3044\u3002\u73fe\u6bb5\u968e\u306b\u304a\u3044\u3066\u79c1\u306e\u610f\u898b\u306f\u304b\u306a\u308a\u9ad8\u3044\u78ba\u7387\u3067\u6ca1\u306b\u306a\u308b\u5c11\u6570\u610f\u898b\u3067\u3042\u308b\u3053\u3068\u306f\u81ea\u8a8d\u3057\u3066\u3044\u308b\u3002\u3068\u306f\u3044\u3048\u3001\u3053\u3046\u3057\u305f\u7570\u306a\u308b\u8996\u5ea7\u304b\u3089TCA\u30b5\u30a4\u30af\u30eb\u3092\u898b\u305f\u3089\u3069\u3046\u306a\u308b\u306e\u304b\u3001\u3082\u3046\u5c11\u3057\u8b70\u8ad6\u3092\u9032\u3081\u3066\u307f\u308b\u3053\u3068\u306b\u3059\u308b\u3002<\/p>\n\n\n\n<p>\u3000\u3044\u307e\u3072\u3068\u3064\u306e\u554f\u984c\u306f\u3001\u7d30\u80de\u5185\u3067\u306eTCA\u56de\u8def\u306e\u5b58\u5728\u610f\u7fa9\u306b\u95a2\u3059\u308b\u5b9a\u7fa9\u306e\u90e8\u5206\u306b\u3042\u308b\u3002\u524d\u7ae0\u306b\u304a\u3044\u3066\u3001\u4eba\u306f\u81ea\u3089\u304c\u5f93\u5c5e\u6804\u990a\u751f\u7269\u3067\u3042\u308b\u3068\u3044\u3046\u5b9f\u611f\uff08\u4e00\u5b9a\u306e\u6642\u9593\u3054\u3068\u306b\u7a7a\u8179\u611f\u306b\u8972\u308f\u308c\u308b\u3053\u3068\uff09\u3092\u6301\u3064\u304c\u6545\u306b\u3001\uff25\uff2d\u7d4c\u8def\u3068\u3044\u3046\u7d4c\u8def\u3092\u30b0\u30eb\u30b3\u30fc\u30b9\u6216\u3044\u306f\u30b0\u30ea\u30b3\u30fc\u30b2\u30f3\uff08\u30c7\u30f3\u30d7\u30f3\uff09\u3092\u51fa\u767a\u7269\u8cea\u3001\u30d4\u30eb\u30d3\u30f3\u9178\u3092\u751f\u6210\u7269\u3068\u3057\u3066\u6d41\u308c\u308bATP\u751f\u7523\u7cfb\u3068\u3057\u3066\u6349\u3048\u308b\u8003\u3048\u65b9\u306b\u89aa\u548c\u6027\u304c\u9ad8\u3044\u306e\u3060\u308d\u3046\u3068\u8ff0\u3079\u305f\u3002\u3057\u304b\u3057\u306a\u304c\u3089\u3001\u72ec\u7acb\u6804\u990a\u751f\u7269\u306b\u306f\u6d41\u308c\u306e\u30d9\u30af\u30c8\u30eb\u304c\u7570\u306a\u308b\uff25\uff2d\u7d4c\u8def\u304c\u5b58\u5728\u3059\u308b\u3002\u4f8b\u3048\u3070\u3001\u690d\u7269\u306b\u304a\u3044\u3066\u306e\uff25\uff2d\u7d4c\u8def\u306f 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a series of reactions two carbons in citrate are oxidized to CO2 and the reaction pathway supplies NADH for use in the oxidative phosphorylation and other metabolic processes. The pathway also supplies important precursor metabolites including 2-oxoglutarate.\u3000\uff08\u30a2\u30bb\u30c1\u30ebCoA \u306b\u7531\u6765\u3059\u308b\uff09\u30af\u30a8\u30f3\u9178\u4e2d\u306e2\u3064\u306e\u70ad\u7d20\u539f\u5b50\u306f\u3001\u4e00\u9023\u306e\u53cd\u5fdc\u306e\u4e2d\u3067\u4e8c\u9178\u5316\u70ad\u7d20\u3078\u3068\u9178\u5316\u3055\u308c\u3001\u9178\u5316\u7684\u30ea\u30f3\u9178\u5316\u3001\u305d\u3057\u3066\u305d\u306e\u4ed6\u306e\u4ee3\u8b1d\u904e\u7a0b\u3067\u4f7f\u7528\u3055\u308c\u308bNADH\u3092\u4f9b\u7d66\u3059\u308b\u3002TCA\u56de\u8def\u306f\u307e\u305f\u30012-\u30aa\u30af\u30bd\u30b0\u30eb\u30bf\u30eb\u9178\u3092\u542b\u3080\u91cd\u8981\u306a\u4ee3\u8b1d\u7269\u3092\u4f9b\u7d66\u3059\u308b\u3002\u300d\u3068\u306e\u3079\u3066\u304a\u308a\u3001\u3053\u306e\u56de\u8def\u304b\u3089\u6d3e\u751f\u3057\u3066\u3044\u304f\u4ed6\u306e\u4ee3\u8b1d-\u7279\u306b\u30a2\u30df\u30ce\u9178\u4ee3\u8b1d\u3092\u610f\u8b58\u3057\u305f\u3088\u3046\u306a\u8a18\u8ff0\u3068\u306a\u3063\u3066\u3044\u308b\u3002\u4f46\u3057\u3001\u524d\u534a\u3067\u3053\u306e\u56de\u8def\u3092\u597d\u6c17\u7684\u904e\u7a0b\u3067\u3042\u308b\u3068\u3057\u305f\u8a18\u8ff0\u304c\u3042\u308b\u305f\u3081\u306b\u3001TCA\u56de\u8def\u304c\u597d\u6c17\u7684\u56de\u8def\u3067\u3042\u308b\u3068\u3044\u3046\u67a0\u7d44\u307f\u306f\u751f\u304d\u3066\u3044\u308b\u3088\u3046\u3060\u3002\u305d\u306e\u70b9\u306b\u554f\u984c\u3042\u308a\u3068\u601d\u3046\u3082\u306e\u306e\u3001KEGG\u306e\u5b9a\u7fa9\u306e\u65b9\u306b\u5e7e\u5206\u304b\u306e\u67d4\u8edf\u6027\u304c\u8a8d\u3081\u3089\u308c\u308b\u3002<\/p>\n\n\n\n<p>\u3000\u4ee5\u4e0b\u3001\u66f8\u304f\u3079\u304d\u304b\u66f8\u304b\u3056\u308b\u3079\u304d\u304b\u5c11\u3005\u8ff7\u3063\u305f\u3002\u672c\u7b4b\u304b\u3089\u5e7e\u5206\u96e2\u308c\u305f\u5185\u5bb9\u306b\u306a\u308b\u304b\u3089\u3067\u3042\u308b\u3002\u3068\u306f\u3044\u3048\u3001TCA\u56de\u8def\u3092\u4f7f\u3063\u3066\u52d5\u7269\u304c\u4e8c\u9178\u5316\u70ad\u7d20\u3092\u56fa\u5b9a\u3059\u308b\u3068\u66f8\u3044\u3066\u3042\u308b\u304b\u3089\u306b\u306f\u5c11\u3005\u30b3\u30e1\u30f3\u30c8\u305b\u3056\u308b\u3092\u5f97\u306a\u3044\u3002\u4e8c\u9178\u5316\u70ad\u7d20\u3092\u56fa\u5b9a\u3059\u308b\u3068\u3044\u3046\u3053\u3068\u306f\u3001\u9084\u5143\u3059\u308b\u3068\u3044\u3046\u3053\u3068\u3068\u540c\u7fa9\u3067\u3042\u308a\u3001TCA\u56de\u8def\u3092\u9084\u5143\u7cfb\u3068\u3057\u3066\u6349\u3048\u308b\u3053\u3068\u3092\u610f\u5473\u3059\u308b\u304b\u3089\u3067\u3042\u308b\u3002\u7dcf\u5408\u7684\u306b\u898b\u308c\u3070\u3001\u6d41\u308c\u308b\u7269\u8cea\u91cf\u3068\u3057\u3066\u306f\u5c11\u91cf\u3067\u3042\u308a\u3001\u70ad\u7d20\u5faa\u74b0\u306b\u304a\u3044\u3066\u306f\u7121\u8996\u3067\u304d\u308b\u3068\u8003\u3048\u3066\u826f\u3044\u304b\u3082\u3057\u308c\u306a\u3044\u304c\u3001\u5c11\u3005\u6c17\u306b\u306a\u3063\u305f\u306e\u3067\u66f8\u304f\u3053\u3068\u306b\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u3000\u3044\u307e\u304b\u308918\u5e74\u307b\u3069\u524d\u306b\u306a\u308b\u3002\u30ab\u30a4\u30b3\u3084\u30af\u30e2\u306e\u7cf8\u3092\u69cb\u6210\u3059\u308b\u30a2\u30df\u30ce\u9178\u4e2d\u306b\u3001\u7a7a\u6c17\u4e2d\u306e\u4e8c\u9178\u5316\u70ad\u7d20\u304c\u53d6\u308a\u8fbc\u307e\u308c\u308b\u3068\u3044\u3046\u5831\u544a\u304c\u51fa\u305f\u3002\u8cea\u91cf\u657013\u306e\u70ad\u7d20\u3092\u542b\u3080\u4e8c\u9178\u5316\u70ad\u7d20\u3092\u7528\u3044\u305f\u30c8\u30ec\u30fc\u30b5\u30fc\u5b9f\u9a13\u306e\u7d50\u679c\u3067\u3042\u3063\u305f\u3002<sup>13<\/sup>\uff23\u3092\u53d6\u308a\u8fbc\u3093\u3060\u4e3b\u306a\u30a2\u30df\u30ce\u9178\u306f\u30a2\u30e9\u30cb\u30f3\u3001\u30a2\u30b9\u30d1\u30e9\u30ae\u30f3\u9178\u3001\u30b0\u30ea\u30b7\u30f3\u3001\u30bb\u30ea\u30f3\u3067\u3042\u308b\u3068\u3055\u308c\u3066\u3044\u305f\u3002<sup>13<\/sup>CNMR\u306e\u7a4d\u5206\u5024\u3092\u53d6\u308a\u8fbc\u307f\u306e\u8a3c\u660e\u306b\u4f7f\u3063\u305f\u5b9f\u9a13\u3067\u3042\u308b\u3002<sup>13<\/sup>CNMR\u306f\u3001\u5b9a\u91cf\u6027\u306b\u3064\u3044\u3066\u306f\u5e7e\u5206\u4e0d\u78ba\u5b9f\u306a\uff08\u7279\u306b\u5b8c\u5168\u30c7\u30ab\u30c3\u30d7\u30ea\u30f3\u30b0\u6761\u4ef6\u3067\u306e\u6e2c\u5b9a\uff09\u6e2c\u5b9a\u6cd5\u3067\u3042\u308b\u3002\u611f\u5ea6\u306f\u4f4e\u304f\u306a\u308b\u304c\u5b9a\u91cf\u6027\u3092\u91cd\u8996\u3057\u305f\u6e2c\u5b9a\u6cd5\u3082\u3042\u308b\u305f\u3081\u30b3\u30e1\u30f3\u30c8\u3057\u306b\u304f\u3044\u304c\u3001\u305d\u3046\u3044\u3046\u3053\u3068\u306f\u7e54\u308a\u8fbc\u307f\u6e08\u307f\u3067\u306e\u7d50\u679c\u3067\u3042\u308a\u7d50\u8ad6\u3067\u3042\u308b\u3068\u601d\u3046\u3002\u3053\u306e\u7d50\u8ad6\u306b\u3088\u308c\u3070\u3001\u52d5\u7269\u3067\u3042\u308b\u6606\u866b\u304c\u3001\u7a7a\u6c17\u4e2d\u306e\u4e8c\u9178\u5316\u70ad\u7d20\u3092\u56fa\u5b9a\u3059\u308b\u3068\u3044\u3046\u7d50\u679c\u306b\u306a\u308a\u3001\u771f\u6838\u751f\u7269\u3067\u3042\u308b\u52d5\u7269\u306f\u70ad\u7d20\u56fa\u5b9a\u3092\u884c\u308f\u306a\u3044\u3068\u601d\u3063\u3066\u3044\u305f\u79c1\u306b\u3068\u3063\u3066\u3001\u7d50\u69cb\u8208\u5473\u3092\u5f15\u304f\u5831\u544a\u3067\u3042\u3063\u305f\u3002<\/p>\n\n\n\n<p>\u3000\u3000\u305f\u3060\u3001\u3044\u304f\u3089\u304b\u306e\u7591\u554f\u306f\u6b8b\u3063\u305f\u3002\u56f3-9\u306b\u8fb2\u696d\u751f\u7269\u8cc7\u6e90\u7814\u7a76\u6240\u306e\u30b5\u30a4\u30c8\u306b\u4e57\u3063\u3066\u3044\u308b\u56f3\u3092\u793a\u3059\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/bamboolab.yamasatoagr.com\/wp\/wp-content\/uploads\/2021\/07\/\u30e2\u30c7\u30eb\u56f3-1024x655.png\" alt=\"\" class=\"wp-image-6869\" width=\"670\" height=\"428\" srcset=\"https:\/\/bamboolab.yamasatoagr.com\/wp\/wp-content\/uploads\/2021\/07\/\u30e2\u30c7\u30eb\u56f3-1024x655.png 1024w, https:\/\/bamboolab.yamasatoagr.com\/wp\/wp-content\/uploads\/2021\/07\/\u30e2\u30c7\u30eb\u56f3-300x192.png 300w, https:\/\/bamboolab.yamasatoagr.com\/wp\/wp-content\/uploads\/2021\/07\/\u30e2\u30c7\u30eb\u56f3-768x491.png 768w, https:\/\/bamboolab.yamasatoagr.com\/wp\/wp-content\/uploads\/2021\/07\/\u30e2\u30c7\u30eb\u56f3.png 1151w\" sizes=\"auto, (max-width: 670px) 100vw, 670px\" \/><figcaption>\u56f3-9\u3000\u5927\u6c17\u4e2d\u306e\u4e8c\u9178\u5316\u70ad\u7d20\u3092\u30ab\u30a4\u30b3\u304c\u7e6d\u7cf8\u3092\u69cb\u6210\u3059\u308b\u30a2\u30df\u30ce\u9178\u306e\u4e2d\u3078\u53d6\u308a\u8fbc\u3080\u4ee3\u8b1d\u56de\u8def\u306e\u30e2\u30c7\u30eb\u56f3<\/figcaption><\/figure>\n\n\n\n<p>\u3000\u3053\u306e\u56f3\u306b\u65bc\u3044\u3066\u306f\u3001\u30d4\u30eb\u30d3\u30f3\u9178\u304c pyrvate carboxylase [EC 6.4.1.1]\u306e\u89e6\u5a92\u4e0b\u306b\u4e8c\u9178\u5316\u70ad\u7d20\u3092\u53d6\u308a\u8fbc\u3093\u3067\u30aa\u30ae\u30b6\u30ed\u9162\u9178\u306b\u306a\u308b\u306e\u3060\u304c\u3001\u3053\u306e\u6bb5\u968e\u3067\u70ad\u7d20\u56fa\u5b9a\u304c\u8d77\u3053\u3063\u3066\u3044\u308b\u3053\u3068\u306b\u306a\u308b\u3002\u30aa\u30ae\u30b6\u30ed\u9162\u9178\u306f\u901a\u5e38\u901a\u308a\u30a2\u30bb\u30c1\u30ebCoA\u3068\u53cd\u5fdc\u3057\u3066\u30af\u30a8\u30f3\u9178\u3092\u4e0e\u3048\u308b\u3002\u30af\u30a8\u30f3\u9178\u304b\u3089\u8131\u6c34\u53cd\u5fdc\u304c\u8d77\u3053\u3063\u3066\u30b7\u30b9\u30a2\u30b3\u30cb\u30c3\u30c8\u9178\u306b\u3001\u30b7\u30b9\u30a2\u30b3\u30cb\u30c3\u30c8\u9178\u306b\u53cd\u5bfe\u5411\u304d\u306e\u6c34\u4ed8\u52a0\u304c\u8d77\u3053\u3063\u3066\u30a4\u30bd\u30af\u30a8\u30f3\u9178\u3068\u306a\u3063\u305f\u5f8c\u3001\u03b1-\u30b1\u30c8\u30b0\u30eb\u30bf\u30eb\u9178\u306b\u5909\u63db\u3055\u308c\u308b\u306e\u3060\u304c\u3001\u30ab\u30a4\u30b3\u306b\u306f\u4e8c\u901a\u308a\u306e\u7d4c\u8def\u304c\u5b58\u5728\u3059\u308b\u3002\u4e00\u3064\u306fisocitrate dehydrogenase (EC&nbsp;1.1.1.41)\u306b\u3088\u3063\u3066\u4e00\u6c17\u306b\u03b1-\u30b1\u30c8\u30b0\u30eb\u30bf\u30eb\u9178\u306b\u306a\u308b\u7d4c\u8def\u3001\u3044\u307e\u4e00\u3064\u306fisocitrate dehydrogenase [EC:1.1.1.42]\u306e\u89e6\u5a92\u4e0b\u306b\u30aa\u30ae\u30b6\u30ed\u30b3\u30cf\u30af\u9178\u3092\u7d4c\u7531\u3057\u3066\u03b1-\u30b1\u30c8\u30b0\u30eb\u30bf\u30eb\u9178\u306b\u306a\u308b\u7d4c\u8def\u306e\u4e8c\u3064\u3067\u3042\u308b\u3002\u3053\u3053\u3067\u03b1-\u30b1\u30c8\u30b0\u30eb\u30bf\u30eb\u9178\u306e\uff12\u3064\u306e\u30ab\u30eb\u30dc\u30ad\u30b7\u30eb\u57fa\u304c\u3068\u3082\u306b\u3001\u591a\u52061\/2\u306e\u78ba\u7387\u3067\u53d6\u308a\u8fbc\u307e\u308c\u305f\u4e8c\u9178\u5316\u70ad\u7d20\u306b\u7531\u6765\u3059\u308b\u3088\u3046\u306b\u63cf\u3044\u3066\u3042\u308b\u3002\u305d\u3046\u3059\u308b\u3068\u3001\u3053\u306e\u3088\u3046\u306a\u5206\u5e03\u306e\u539f\u56e0\u3068\u306a\u308b\u6bb5\u968e\u306f\uff12\u3064\u306b\u7d5e\u3089\u308c\u308b\u3002<\/p>\n\n\n\n<p>\u3000\uff11\u3064\u306e\u53ef\u80fd\u6027\u306f\u30a2\u30bb\u30c1\u30ebCoA\u306e\u30aa\u30ae\u30b6\u30ed\u9162\u9178\u306e\u30ab\u30eb\u30dc\u30cb\u30eb\u57fa\u3078\u306e\u4ed8\u52a0\u304c<em>re<\/em>\u9762 <em>si<\/em>\u9762\u3092\u533a\u5225\u305b\u305a\u306b\u8d77\u3053\u308b\u5834\u5408\u3067\u3042\u308a\u3001\u3044\u307e\u3072\u3068\u3064\u306e\u53ef\u80fd\u6027\u306f\u30af\u30a8\u30f3\u9178\u304b\u3089<em>cis<\/em>-\u30a2\u30b3\u30cb\u30c3\u30c8\u9178\u3078\u306e\u5909\u63db\u304c\u30d7\u30ed\u30ad\u30e9\u30ea\u30c6\u30a3\u30fc\u3092\u7121\u8996\u3057\u3066\u8d77\u3053\u308b\u5834\u5408\u3067\u3042\u308b\u3002\u3068\u3053\u308d\u304c\u3001\u6700\u521d\u306e\u4ed8\u52a0\u53cd\u5fdc\u306f\u30ab\u30eb\u30dc\u30cb\u30eb\u57fa\u306e<em>si<\/em>\u9762\u5074\u304b\u3089\u8d77\u3053\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u308b\u3057\u300a<em>Biochemistry<\/em>, <strong>29<\/strong>, 2213-2219\uff081990\uff09\u300b\u3001\u30af\u30a8\u30f3\u9178\u304b\u3089<em>cis<\/em>-\u30a2\u30b3\u30cb\u30c3\u30c8\u9178\u3078\u306e\u5909\u63db\u306f <em>ProR<\/em>\u5074\u306e\u5074\u9396\u306b\u4e8c\u91cd\u7d50\u5408\u304c\u5f62\u6210\u3055\u308c\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u308b\u300a<em>Proc. Natl. Acad. Sci<\/em>., 93, 13699-13703 (1996)\u300b\u3002\u305d\u3046\u306a\u308b\u3068\u03b1-\u30b1\u30c8\u30b0\u30eb\u30bf\u30eb\u9178\u306e\uff12\u3064\u306e\u30ab\u30eb\u30dc\u30ad\u30b7\u30eb\u57fa\u304c\u3068\u3082\u306b\u53d6\u308a\u8fbc\u307e\u308c\u305f\u4e8c\u9178\u5316\u70ad\u7d20\u306b\u7531\u6765\u3059\u308b\u3068\u63cf\u3044\u3066\u3042\u308b\u3053\u306e\u56f3\u306f\u3069\u3053\u304b\u304a\u304b\u3057\u3044\u3002\u3055\u3089\u306b\u3001\u6700\u521d\u306b\u56fa\u5b9a\u3055\u308c\u305f\u4e8c\u9178\u5316\u70ad\u7d20\u306b\u7531\u6765\u3059\u308b\u3001\u03b1-\u30b1\u30c8\u30b0\u30eb\u30bf\u30eb\u9178\u306e\u03b1-\u30b1\u30c8\u9178\u5074\u306e\u30ab\u30eb\u30dc\u30ad\u30b7\u30eb\u57fa\u306f\u8131\u70ad\u9178\u3067\u9664\u304b\u308c\u308b\u305f\u3081\u3001\u56f39\u306e\u3088\u3046\u306b\u56de\u8def\u3092\u53f3\u56de\u308a\u3057\u3066\u30aa\u30ad\u30b5\u30ed\u9162\u9178\u306b\u623b\u3063\u305f\u5f8c\u30a2\u30df\u30ce\u9178\u3078\u306e\u5909\u63db\u304c\u884c\u308f\u308c\u308b\u3068\u3059\u308c\u3070\u3001\u305d\u3053\u3067\u751f\u6210\u3059\u308b\u30a2\u30df\u30ce\u9178\u306b\u306f\u53d6\u308a\u8fbc\u307e\u308c\u306a\u3044\u306f\u305a\u3067\u3042\u308b\u3002\uff08\u56f3-10\u53c2\u7167\uff09<\/p>\n\n\n\n<figure class=\"wp-block-image size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/bamboolab.yamasatoagr.com\/wp\/wp-content\/uploads\/2021\/07\/\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8-2021-07-26-1.56.25.png\" alt=\"\" class=\"wp-image-6893\" width=\"670\" height=\"759\" srcset=\"https:\/\/bamboolab.yamasatoagr.com\/wp\/wp-content\/uploads\/2021\/07\/\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8-2021-07-26-1.56.25.png 798w, https:\/\/bamboolab.yamasatoagr.com\/wp\/wp-content\/uploads\/2021\/07\/\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8-2021-07-26-1.56.25-265x300.png 265w, https:\/\/bamboolab.yamasatoagr.com\/wp\/wp-content\/uploads\/2021\/07\/\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8-2021-07-26-1.56.25-768x871.png 768w\" sizes=\"auto, (max-width: 670px) 100vw, 670px\" \/><figcaption>\u56f310\u3000\u30d4\u30eb\u30d3\u30f3\u9178\u306b\u53d6\u308a\u8fbc\u307e\u308c\u305f\u4e8c\u9178\u5316\u70ad\u7d20\u306f2-Oxoglutarate\uff08\u03b1-\u30b1\u30c8\u30b0\u30eb\u30bf\u30eb\u9178\uff09\u304b\u3089\u30b3\u30cf\u30af\u9178\u3078\u306e\u6bb5\u968e\u3067\u7cfb\u5916\u306b\u653e\u51fa\u3055\u308c\u308b<\/figcaption><\/figure>\n\n\n\n<p>\u3000\u3069\u3046\u8003\u3048\u308c\u3070\u3088\u3044\u304b\uff1f\uff11\u3064\u306e\u53ef\u80fd\u6027\u306f\u30ab\u30a4\u30b3\u306e\u6301\u3064pyrvate carboxylase [EC: 6.4.1.1]\u3084isocitrate dehydrogenase (EC:1.1.1.41) \u3001isocitrate dehydrogenase [EC:1.1.1.42]\u304c\u3001\u30d7\u30ed\u30ad\u30e9\u30ea\u30c6\u30a3\u3092\u533a\u5225\u3059\u308b\u7279\u7570\u6027\u3092\u6301\u3063\u3066\u3044\u306a\u3044\u3068\u8003\u3048\u308b\u3053\u3068\u3067\u3042\u308b\u3002\u305d\u3046\u3067\u3042\u308c\u3070\u554f\u984c\u306f\u306a\u3044\u304c\u3001\u305d\u3093\u306a\u3053\u3068\u306f\u306a\u3044\u3068\u601d\u3046\u3002\u3053\u306e\u53d6\u308a\u8fbc\u307f\u3092\u8aac\u660e\u3067\u304d\u308b\u5408\u7406\u7684\u306a\u8003\u3048\u65b9\u304c\u3042\u308a\u5f97\u308b\u3068\u8003\u3048\u3066\u3044\u308b\u3002<\/p>\n\n\n\n<p>\u3000\u516c\u958b\u306e\u4e88\u544a\u3092\u3057\u3066\u304a\u304d\u306a\u304c\u3089\u56f3-10\u306e\u63cf\u753b\u3067\u6238\u60d1\u3063\u3066\u3044\u307e\u3059\u3002\u3053\u3053\u3092\u3046\u307e\u304f\u63cf\u3044\u3066\u304a\u304b\u306a\u3044\u3068\u7acb\u4f53\u5316\u5b66\u306b\u7cbe\u901a\u3057\u305f\u4eba\u3067\u306a\u3044\u3068\u4f55\u3092\u8a00\u3063\u3066\u3044\u308b\u306e\u304b\u7406\u89e3\u304c\u96e3\u3057\u3044\u3068\u601d\u3046\u3002\u30d7\u30ed\u30ad\u30e9\u30ea\u30c6\u30a3\u306e\u5b9a\u7fa9\u3092\u542b\u3081\u3001\u3053\u306e\u90e8\u5206\u306b\u3064\u3044\u3066\u306f\u6570\u65e5\u4e2d\u306b\u30a2\u30c3\u30d7\u3059\u308b\u4e88\u5b9a\u3067\u3059\u3002\u3042\u307e\u308a\u6642\u9593\u304c\u7a7a\u3044\u3066\u3082\u5c11\u3005\u5bc2\u3057\u3044\u306e\u3067\u3001\u53d6\u308a\u6025\u304e\u3001\u3053\u3053\u307e\u3067\u3092\u30a2\u30c3\u30d7\u3057\u3066\u304a\u304d\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u6b74\u53f2\u751f\u7269\u5b66\u3000TCA\u56de\u8def\u3078\u306e\u7570\u8ad6\u30006\u3000\u306b\u7d9a\u304f<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u3000\u8981\u3059\u308b\u306b\u3001\u5927\u3057\u305f\u3053\u3068\u3092\u4e91\u3063\u3066\u3044\u308b\u308f\u3051\u3067\u306f\u306a\u3044\u3002TCA\u56de\u8def\u3068\u96fb\u5b50\u4f1d\u9054\u7cfb\u306f\u5206\u3051\u3066\u8003 &hellip; <a href=\"https:\/\/bamboolab.yamasatoagr.com\/?p=5291\">\u7d9a\u304d\u3092\u8aad\u3080 <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[146,8],"tags":[161,160,145],"class_list":["post-5291","post","type-post","status-publish","format-standard","hentry","category-tca","category-8","tag-161","tag-160","tag-tca"],"_links":{"self":[{"href":"https:\/\/bamboolab.yamasatoagr.com\/index.php?rest_route=\/wp\/v2\/posts\/5291","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/bamboolab.yamasatoagr.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/bamboolab.yamasatoagr.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/bamboolab.yamasatoagr.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/bamboolab.yamasatoagr.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=5291"}],"version-history":[{"count":14,"href":"https:\/\/bamboolab.yamasatoagr.com\/index.php?rest_route=\/wp\/v2\/posts\/5291\/revisions"}],"predecessor-version":[{"id":7867,"href":"https:\/\/bamboolab.yamasatoagr.com\/index.php?rest_route=\/wp\/v2\/posts\/5291\/revisions\/7867"}],"wp:attachment":[{"href":"https:\/\/bamboolab.yamasatoagr.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=5291"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/bamboolab.yamasatoagr.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=5291"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/bamboolab.yamasatoagr.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=5291"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}